Abstract
Flexible control of behavior depends on the representation, maintenance, and updating of context information in working memory, which is thought to rely on the prefrontal cortex (PFC). However, in contrast to maintenance, the dynamics of context activation and updating have not been well studied. To identify neural signals associated with context updating, we compared event-related potentials associated with cues that did or did not provide task-relevant context information. The earliest effect of context was detected 200 msec following cue onset and had a scalp topography consistent with a generator in the PFC. Subsequent effects of context were detected at 400-700 msec following cue onset (P3b), with a broad scalp distribution spanning posterior areas, and during the final 300 msec preceding the target, with a probable generator in the medial frontal cortex. We propose that the effect of context on P2 is consistent with the onset of context updating in the PFC. Subsequent components may be indicative of activation of task-relevant posterior regions and context maintenance.
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Anllo-Vento, L., Luck, S. J., & Hillyard, S. A. (1998). Spatiotemporal dynamics of attention to color: Evidence from human electrophysiology. Human Brain Mapping, 6, 216–238. doi:10.1002/ (SICI)1097-0193(1998)6:4<g216::AID-HBM3>3.0.CO;2-6
Astle, D. E., Jackson, G. M., & Swainson, R. (2006). Dissociating neural indices of dynamic cognitive control in advance task-set preparation: An ERP study of task switching. Brain Research, 1125, 94–103. doi:10.1016/j.brainres.2006.09.092
Astle, D. E., Jackson, G. M., & Swainson, R. (2008a). Fractionating the cognitive control required to bring about a change in task: A densesensor event-related potential study. Journal of Cognitive Neuroscience, 20, 255–267. doi:10.1162/jocn.2008.20015
Astle, D. E., Jackson, G. M., & Swainson, R. (2008b). The role of spatial information in advance task-set control: An event-related potential study. European Journal of Neuroscience, 28, 1404–1418. doi:10.1111/j.1460-9568.2008.06439.x
Bar, M. (2003). A cortical mechanism for triggering top-down facilitation in visual object recognition. Journal of Cognitive Neuroscience, 15, 600–609.
Bar, M., Kassam, K., Ghuman, A. S., Boshyan, J., Schmidt, A. M., Dale, A. M., et al. (2006). Top-down facilitation of visual recognition. Proceedings of the National Academy of Sciences, 103, 449–454.
Barcelo, F., Escera, C., Corral, M. J., & Perianez, J. A. (2006). Task switching and novelty processing activate a common neural network for cognitive control. Journal of Cognitive Neuroscience, 18, 1734–1748. doi:10.1162/jocn.2006.18.10.1734
Bledowski, C., Prvulovic, D., Hoechstetter, K., Scherg, M., Wibral, M., Goebel, R., & Linden, D. E. J. (2004). Localizing P300 generators in visual target and distractor processing: A combined event-related potential and functional magnetic resonance imaging study. Journal of Neuroscience, 24, 9353–9360. doi:10.1523/ JNEUROSCI.1897-04.2004
Brass, M., Ullsperger, M., Knoesche, T. R., von Cramon, D. Y., & Phillips, N. A. (2005). Who comes first? The role of the prefrontal and parietal cortex in cognitive control. Journal of Cognitive Neuroscience, 17, 1367–1375. doi:10.1162/0898929054985400
Braver, T. S., & Cohen, J. D. (2000). On the control of control: The role of dopamine in regulating prefrontal function and working memory. In S. Monsell & J. Driver (Eds.), Control of cognitive processes: Attention and performance XVIII (pp. 713–737). Cambridge, MA: MIT Press.
Braver, T. S., Reynolds, J. R., & Donaldson, D. I. (2003). Neural mechanisms of transient and sustained cognitive control during task switching. Neuron, 39, 713–726. doi:10.1016/S0896-627303)00466-5
Brown, J. W., Reynolds, J. R., & Braver, T. S. (2007). A computational model of fractionated conflict-control mechanisms in taskswitching. Cognitive Psychology, 55, 37–85. doi:10.1016/j.cogpsych.2006.09.005
Bunge, S. A. (2004). How we use rules to select actions: A review of evidence from cognitive neuroscience. Cognitive, Affective, & Behavioral Neuroscience, 4, 564–579. doi:10.3758/CABN.4.4.564
Cohen, J. D., Dunbar, K., & McClelland, J. L. (1990). On the control of automatic processes: A parallel distributed processing account of the Stroop effect. Psychological Review, 97, 332–361. doi:10.1037/ 0033-295X.97.3.332
Cox, R. W. (1996). AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Computers & Biomedical Research, 29, 162–173. doi:10.1006/cbmr.1996.0014
Deecke, L., Scheid, P., & Kornhuber, H. H. (1969). Distribution of readiness potential pre-motion positivity, and motor potential of human cerebral cortex preceding voluntary finger movements. Experimental Brain Research, 7, 158–168. doi:10.1007/BF00235441
De Jong, R. (2000). An intention-activation account of residual switch costs. In S. Monsell & J. Driver (Eds.), Control of cognitive processes: Attention and performance XVIII (pp. 357–376). Cambridge, MA: MIT Press.
D’Esposito, M. (2007). From cognitive to neural models of working memory. Philosophical Transactions of the Royal Society B, 362, 761–772. doi:10.1098/rstb.2007.2086
Dien, J., Spencer, K. M., & Donchin, E. (2003). Localization of the event-related potential novelty response as defined by principal components analysis. Cognitive Brain Research, 17, 637–650. doi:10.1016/ S0926-6410(03)00188-5
Di Russo, F., Martinez, A., Sereno, M. I., Pitzalis, S., & Hillyard, S. A. (2002). Cortical sources of the early components of the visual evoked potential. Human Brain Mapping, 15, 95–111. doi:10.1002/ hbm.10010
Donchin, E., & Coles, M. G. H. (1988). Is the P300 component a manifestation of context updating? Behavioral & Brain Sciences, 11, 357–427.
Efron, B., & Tibshirani, R. (1986). Bootsrap methods for standard errors, confidence intervals, and other measures of statistical accuracy. Statistical Sciences, 1, 54–77. or]Eshel, N., Luka, J., Lenartowicz, A., Nystrom, L. E., & Cohen, J. D. (2008, June). Transiently disrupting right prefrontal cortex interferes with updating of working memory. Poster presented at the 14th Annual Meeting of the Organization for Human Brain Mapping, Melbourne.
Foxe, J. J., Simpson, G. V., Ahlfors, S. P., & Saron, C. D. (2005). Biasing the brain’s attentional set: I. Cue driven deployments of intersensory selective attention. Experimental Brain Research, 166, 370–392. doi:10.1007/s00221-005-2378-7
Frank, M. J., Loughry, B., & O’Reilly, R. C. (2001). Interactions between frontal cortex and basal ganglia in working memory: A computational model. Cognitive, Affective, & Behavioral Neuroscience, 1, 137–160. doi:10.3758/CABN.1.2.137
Friedman, D., Cycowicz, Y. M., & Gaeta, H. (2001). The novelty P3: An event-related brain potential (ERP) sign of the brain’s evaluation of novelty. Neuroscience & Biobehavioral Reviews, 25, 355–373. doi:10.1016/S0149-7634(01)00019-7
Grave de Peralta Menendez, R., Murray, M. M., Michel, C. M., Martuzzi, R., & Gonzalez Andino, S. L. (2004). Electrical neuroimaging based on biophysical constraints. NeuroImage, 21, 527–539. doi:10.1016/j.neuroimage.2003.09.051
Halgren, E., Baudena, P., Heit, G., Clarke, J. M., Marinkovic, K., Chauvel, P., & Clarke, M. (1994). Spatio-temporal stages in face and word processing: 2. Depth-recorded potentials in the human frontal and Rolandic cortices. Journal of Physiology (Paris), 88, 51–80. doi:10.1016/0928-4257(94)90093-0
Halgren, E., Marinkovic, K., & Chauvel, P. (1998). Generators of the late cognitive potentials in auditory and visual oddball tasks. Electroencephalography & Clinical Neurophysiology, 106, 156–164. doi:10.1016/S0013-4694(97)00119-3
Hamano, T., Luders, H. O., Ikeda, A., Collura, T. F., Comair, Y. G., & Shibasaki, H. (1997). The cortical generators of the contingent negative variation in humans: A study with subdural electrodes. Electroencephalography & Clinical Neurophysiology, 104, 257–268. doi:10.1016/S0168-5597(97)96107-4
Hillyard, S. A., & Münte, T. F. (1984). Selective attention to color and location: An analysis with event-related brain potentials. Perception & Psychophysics, 36, 185–198.
Karayanidis, F., Coltheart, M., Michie, P. T., & Murphy, K. (2003). Electrophysiological correlates of anticipatory and poststimulus components of task switching. Psychophysiology, 40, 329–348. doi:10.1111/1469-8986.00037
Kieffaber, P. D., & Hetrick, W. P. (2005). Event-related potential correlates of task switching and switch costs. Psychophysiology, 42, 56–71. doi:10.1111/j.1469-8986.2005.00262.x
Lavric, A., Mizon, G. A., & Monsell, S. (2008). Neurophysiological signature of effective anticipatory task-set control: A task-switching investigation. European Journal of Neuroscience, 28, 1016–1029. doi:10.1111/j.1460-9568.2008.06372.x
Linden, D. E. J. (2005). The P300: Where in the brain is it produced and what does it tell us? Neuroscientist, 11, 563–576. doi:10.1177/ 1073858405280524
Lobaugh, N. J., West, R., & McIntosh, A. R. (2001). Spatiotemporal analysis of experimental differences in event-related potential data with partial least squares. Psychophysiology, 38, 517–530. doi:10.1017/ S0048577201991681
Logan, G. D., & Bundesen, C. (2003). Clever homunculus: Is there an endogenous act of control in the explicit task-cuing procedure? Journal of Experimental Psychology: Human Perception & Performance, 29, 575–599.
Luck, S. J., & Hillyard, S. A. (1994). Electrophysiological correlates of feature analysis during visual search. Psychophysiology, 31, 291–308.
Makeig, S., Westerfield, M., Jung, T.-P., Covington, J., Townsend, J., Sejnowski, T. J., & Courchesne, E. (1999). Functionally independent components of the late positive event-related potential during visual spatial attention. Journal of Neuroscience, 19, 2665–2680.
Mayr, U., & Kliegl, R. (2003). Differential effects of cue changes and task changes on task-set selection costs. Journal of Experimental Psychology: Learning, Memory, & Cognition, 29, 362–372.
Miller, E. K., & Cohen, J. D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167–202. doi:10.1146/annurev.neuro.24.1.167
Monsell, S. (2003). Task switching. Trends in Cognitive Sciences, 7, 134–140. doi:10.1016/S1364-6613(03)00028-7
Monsell, S., & Mizon, G. A. (2006). Can the task-cuing paradigm measure an endogenous task-set reconfiguration process? Journal of Experimental Psychology: Human Perception & Performance, 32, 493–516. doi:10.1037/0096-1523.32.3.493
Mueller, S. C., Swainson, R., & Jackson, G. M. (2007). Behavioural and neurophysiological correlates of bivalent and univalent responses during task switching. Brain Research, 1157, 56–65. doi:10.1016/ j.brainres.2007.04.046
Mueller, S. C., Swainson, R., & Jackson, G. M. (2009). ERP indices of persisting and current inhibitory control: A study of saccadic task switching. NeuroImage, 45, 191–197. doi:10.1016/j.neuroimage.2008.11.019
Mulert, C., Pogarell, O., Juckel, G., Rujescu, D., Giegling, I., Rupp, D., et al. (2004). The neural basis of the P300 potential: Focus on the time-course of the underlying cortical generators. European Archives of Psychiatry & Clinical Neuroscience, 254, 190–198. doi:10.1007/s00406-004-0469-2
Nambu, A., & Llinas, R. (1997). Morphology of globus pallidus neurons: Its correlation with electrophysiology in guinea pig brain slices. Journal of Comparative Neurology, 377, 85–94. doi:10.1002/ (SICI)1096-9861(19970106)377:1<85::AID-CNE8>3.0.CO;2-F
Nichols, T. E., & Holmes, A. P. (2001). Nonparametric permutation tests for functional neuroimaging: A primer with examples. Human Brain Mapping, 15, 1–25. doi:10.1002/hbm.1058
Nicholson, R., Karayanidis, F., Bumak, E., Poboka, D., & Michie, P. T. (2006). ERPs dissociate the effects of switching task sets and task cues. Brain Research, 1095, 107–123. doi:10.1016/j.brainres.2006.04.016
Nicholson, R., Karayanidis, F., Davies, A., & Michie, P. T. (2006). Components of task-set reconfiguration: Differential effects of “switch-to” and “switch-away” cues. Brain Research, 1121, 160–176. doi:10.1016/j.brainres.2006.08.101
Nicholson, R., Karayanidis, F., Poboka, D., Heathcote, A., & Michie, P. T. (2005). Electrophysiological correlates of anticipatory task-switching processes. Psychophysiology, 42, 540–554. doi:10.1111/j.1469-8986.2005.00350.x
Nunez, P. L., Silberstein, R. B., Cadusch, P. J., Wijesinghe, R. S., Westdorp, A. F., & Srinivasan, R. (1994). A theoretical and experimental study of high resolution EEG based on surface Laplacians and cortical imaging. Electroencephalography & Clinical Neurophysiology, 90, 40–57. doi:10.1016/0013-4694(94)90112-0
O’Reilly, R. C., Noelle, D. C., Braver, T. S., & Cohen, J. D. (2002). Prefrontal cortex and dynamic categorization tasks: Representational organization and neuromodulatory control. Cerebral Cortex, 12, 246–257.
Park, H.-J., Kwon, J. S., Youn, T., Pae, J. S., Kim, J.-J., Kim, M. S., & Ha, K.-S. (2002). Statistical parametric mapping of LORETA using high density EEG and individual MRI: Application to mismatch negativities in schizophrenia. Human Brain Mapping, 17, 168–178. doi:10.1002/hbm.10059
Pascual-Marqui, R. D. (2002). Standardized low-resolution brain electromagnetic tomography (sLORETA): Technical details. Methods & Findings in Experimental & Clinical Pharmacology, 24D, 5–12.
Passingham, D., & Sakai, K. (2004). The prefrontal cortex and working memory: Physiology and brain imaging. Current Opinion in Neurobiology, 14, 163–168. doi:10.1016/j.conb.2004.03.003
Perianez, J. A., Maestu, F., Barcelo, F., Fernandez, A., Amo, C., & Ortiz Alonso, T. (2004). Spatiotemporal brain dynamics during preparatory set shifting: MEG evidence. NeuroImage, 21, 687–695. doi:10.1016/j.neuroimage.2003.10.008
Polich, J. (2007). Updating P300: An integrative theory of P3a and P3b. Clinical Neurophysiology, 118, 2128–2148. doi:10.1016/j.clinph.2007.04.019
Potts, G. F. (2004). An ERP index of task relevance evaluation of visual stimuli. Brain & Cognition, 56, 5–13. doi:10.1016/j.bandc.2004.03.006
Potts, G. F., Martin, L. E., Burton, P., & Montague, P. R. (2006). When things are better off worse than expected: The medial frontal cortex and the allocation of processing resources. Journal of Cognitive Neuroscience, 18, 1112–1119.
Rainer, G., Asaad, W. F., & Miller, E. K. (1998). Selective representation of relevant information by neurons in the primate prefrontal cortex. Nature, 393, 577–579. doi:10.1038/31235
Reynolds, J. R., Braver, T. S., Brown, J. W., & Van der Stigchel, S. (2006). Computational and neural mechanisms of task switching. Neurocomputing, 69, 1332–1336. doi:10.1016/j.neucom.2005.12.102
Rosvold, H. E., Mirsky, A. F., Sarason, I., Bransome, E. D., Jr., & Beck, L. H. (1956). A continuous performance test of brain damage. Journal of Consulting Psychology, 20, 343–350.
Rubin, O., & Meiran, N. (2005). On the origins of the task mixing cost in the task-switching paradigm. Journal of Experimental Psychology: Learning, Memory, & Cognition, 31, 1477–1491.
Ruchkin, D. S., Johnson, R., Canoune, H. L., Ritter, W., & Hammer, M. (1990). Multiple sources of P3b associated with different types of information. Psychophysiology, 27, 157–176. doi:10.1111/ j.1469-8986.1990.tb00367.x
Rushworth, M. F. S., Buckley, M. J., Behrens, T. E. J., Walton, M. E., & Bannerman, D. M. (2007). Functional organization of the medial frontal cortex. Current Opinion in Neurobiology, 17, 220–227. doi:10.1016/j.conb.2007.03.001
Rushworth, M. F. S., Hadland, K. A., Paus, T., & Sipila, P. K. (2002). Role of the human medial frontal cortex in task switching: A combined fMRI and TMS study. Journal of Neurophysiology, 87, 2577–2592.
Rushworth, M. F. S., Passingham, R. E., & Nobre, A. C. (2002). Components of switching intentional set. Journal of Cognitive Neuroscience, 14, 1139–1150. doi:10.1162/089892902760807159
Rushworth, M. F. S., Passingham, R. E., & Nobre, A. C. (2005). Components of attentional set-switching. Experimental Psychology, 52, 83–98. doi:10.1027/1618-3169.52.2.83
Rushworth, M. F. S., Walton, M. E., Kennerley, S. W., & Banner-man, D. M. (2004). Action sets and decisions in the medial frontal cortex. Trends in Cognitive Sciences, 8, 410–417. doi:10.1016/j.tics.2004.07.009
Scherg, M., & Picton, T. W. (1991). Separation and identification of event-related potential components by brain electric source analysis. Electroencephalography & Clinical Neurophysiology, 42(Suppl.), 24–37.
Schneider, W., & Shiffrin, R. M. (1977). Controlled and automatic human information processing: 1. Detection, search, and attention. Psychological Review, 84, 1–66.
Stoet, G., & Snyder, L. H. (2009). Neural correlates of executive control functions in the monkey. Trends in Cognitive Sciences, 13, 228–234. doi:10.1016/j.tics.2009.02.002
Swainson, R., Jackson, S. R., & Jackson, G. M. (2006). Using advance information in dynamic cognitive control: An ERP study of task-switching. Brain Research, 1105, 61–72. doi:10.1016/j.brainres.2006.02.027
Talairach, J., & Tournoux, P. (1988). Co-planar sterotaxic atlas of the human brain. Stuttgart: Thieme.
Todd, M. T., Niv, Y., & Cohen, J. D. (2009). Learning to use working memory in partially observable environments through dopaminergic reinforcement. In D. Koller, D. Schuurmans, Y. Bengio, & L. Bottou (Eds.), Neural information processing systems (pp. 1689–1696). Cambridge, MA: MIT Press.
Vogel, E. K., Luck, S. J., & Shapiro, K. L. (1998). Electrophysiological evidence for a postperceptual locus of suppression during the attentional blink. Journal of Experimental Psychology: Human Perception & Performance, 24, 1656–1674. doi:10.1037/0096-1523.24.6.1656
Wagner, M., Fuchs, M., & Kastner, J. (2004). Evaluation of sLORETA in the presence of noise and multiple sources. Brain Topography, 16, 277–280. doi:10.1023/B:BRAT.0000032865.58382.62
Walter, W. G., Aldridge, V. J., McCallum, W. C., & Cooper, R. (1964). Contingent negative variation: Electrocortical sign of sensorimotor association in man. Electroencephalography & Clinical Neurophysiology, 17, 340–341.
Wylie, G. R., & Allport, A. (2000). Task switching and the measurement of “switch costs.” Psychological Research, 63, 212–233. doi:10.1007/s004269900003
Wylie, G. R., Javitt, D. C., & Foxe, J. J. (2003). Task switching: A high-density electrical mapping study. NeuroImage, 20, 2322–2342. doi:10.1016/j.neuroimage.2003.08.010
Wylie, G. R., Murray, M. M., Javitt, D. C., & Foxe, J. J. (2009). Distinct neurophysiological mechanisms mediate mixing costs and switch costs. Journal of Cognitive Neuroscience, 21, 105–118. doi:10.1162/ jocn.2009.21009
Yeung, N., Nystrom, L. E., Aronson, J. A., & Cohen, J. D. (2006). Between-task competition and cognitive control in task switching. Journal of Neuroscience, 26, 1429–1438. doi:10.1523/JNEUROSCI.3109-05.2006
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Funding for this research was provided by the National Institutes of Health (NIMH) Grant 5 R01 MH052854, awarded to J.D.C. This work was completed with invaluable assistance in data analysis from Demetrios Voreades and Richard Greenblatt (Source Signal Imaging, Inc.), as well as useful design suggestions from Samuel M. McClure, John Kounios, and Steven Luck.
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Lenartowicz, A., Escobedo-Quiroz, R. & Cohen, J.D. Updating of context in working memory: An event-related potential study. Cognitive, Affective, & Behavioral Neuroscience 10, 298–315 (2010). https://doi.org/10.3758/CABN.10.2.298
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DOI: https://doi.org/10.3758/CABN.10.2.298