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Study found that melatonin increases total sleep time in children with neurodevelopmental delay but that the increase is not clinically worthwhile and that melatonin is effective in reducing sleep-onset latency in children with neurodevelopmental delay and that the reduction is both clinically important and statistically significant.

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RE Appleton, AP Jones, C Gamble, PR Williamson, L Wiggs, P Montgomery, A Sutcliffe, C Barker & P Gringras.

RE Appleton 1,*, AP Jones 2, C Gamble 2, PR Williamson 2, L Wiggs 3, P Montgomery 4, A Sutcliffe 5, C Barker 1, P Gringras 6

1 Alder Hey Children’s NHS Foundation Trust, Liverpool, UK
2 Medicines for Children Research Network Clinical Trials Unit, University of Liverpool, Liverpool, UK
3 Department of Psychology, Oxford Brookes University, Oxford, UK
4 Centre for Evidence Based Intervention, University of Oxford, Oxford, UK
5 University College London, London, UK
6 Guy’s and St Thomas’ NHS Foundation Trust, London, UK
* Corresponding author Email: Richard.Appleton@alderhey.nhs.uk

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