Abstract
This study describes the current situation and projects dynamic trends for HIV prevalence in a highly endemic area of China, Liangshan Prefecture, Sichuan Province. Epidemiological, behavioral, and population census data from multiple sources were analyzed to extract input for an Asian Epidemic Model (AEM). Fitting curves to historical trends in HIV prevalence were used as a baseline, and future intervention scenarios were explored using the AEM. For 2007, modeled data suggested ≉0.5% adult HIV prevalence in Liangshan, with an estimated 17,450 people living with HIV/AIDS and 3,400 new infections. With current high risk behaviors, the model predicts that adult prevalence will rise to 1.5% by 2020. Increased condom use and clean needle exchange among injection drug users (IDUs) have slowed the epidemic. The source of new HIV infections will change from a preponderance of IDU-related infections in 2007 (65.9%) to a mixed epidemic in 2020 (general population heterosexuals 45.2%, IDU 38.6%, homosexual transmission between men 12.7%, female sex workers and their clients 3.5%). We anticipate rising prevalence, stable incidence, and higher representation of sexual transmission over time. Prevention investments should target specific interventions toward subgroups at highest risk, given that both IDUs and men who have sex with men will likely represent a majority of cases and serve as a bridge population.
Keywords: HIV, Asian Epidemic Model, Epidemiologic modeling, Substance abuse, Homosexuality, China
Current HIV Research
Title: Projecting Dynamic Trends for HIV/AIDS in a Highly Endemic Area of China: Estimation Models for Liangshan Prefecture, Sichuan Province
Volume: 7 Issue: 4
Author(s): Li Liu, Rongsheng Luan, Wen Yang, Linglin Zhang, Jianhua Zhang, Lei Nan, Jun Huang, Ying Hu, Guangyu Mao, Liao Feng, Yuhan Gong, Sten H. Vermund and Yujiang Jia
Affiliation:
Keywords: HIV, Asian Epidemic Model, Epidemiologic modeling, Substance abuse, Homosexuality, China
Abstract: This study describes the current situation and projects dynamic trends for HIV prevalence in a highly endemic area of China, Liangshan Prefecture, Sichuan Province. Epidemiological, behavioral, and population census data from multiple sources were analyzed to extract input for an Asian Epidemic Model (AEM). Fitting curves to historical trends in HIV prevalence were used as a baseline, and future intervention scenarios were explored using the AEM. For 2007, modeled data suggested ≉0.5% adult HIV prevalence in Liangshan, with an estimated 17,450 people living with HIV/AIDS and 3,400 new infections. With current high risk behaviors, the model predicts that adult prevalence will rise to 1.5% by 2020. Increased condom use and clean needle exchange among injection drug users (IDUs) have slowed the epidemic. The source of new HIV infections will change from a preponderance of IDU-related infections in 2007 (65.9%) to a mixed epidemic in 2020 (general population heterosexuals 45.2%, IDU 38.6%, homosexual transmission between men 12.7%, female sex workers and their clients 3.5%). We anticipate rising prevalence, stable incidence, and higher representation of sexual transmission over time. Prevention investments should target specific interventions toward subgroups at highest risk, given that both IDUs and men who have sex with men will likely represent a majority of cases and serve as a bridge population.
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Liu Li, Luan Rongsheng, Yang Wen, Zhang Linglin, Zhang Jianhua, Nan Lei, Huang Jun, Hu Ying, Mao Guangyu, Feng Liao, Gong Yuhan, Vermund H. Sten and Jia Yujiang, Projecting Dynamic Trends for HIV/AIDS in a Highly Endemic Area of China: Estimation Models for Liangshan Prefecture, Sichuan Province, Current HIV Research 2009; 7 (4) . https://dx.doi.org/10.2174/157016209788680642
DOI https://dx.doi.org/10.2174/157016209788680642 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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HIV vaccine development
The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
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