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Achieving Remission as a Routine Goal of Pharmacotherapy in Attention-Deficit Hyperactivity Disorder

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Abstract

Remission should be the goal of attention-deficit hyperactivity disorder (ADHD) treatment. However, there is no universally accepted definition of remission in ADHD, although clinical studies use a number of criteria. This article examines current research into the concept of remission in ADHD by reviewing the literature for definition and achievement of remission in children and adults with ADHD. Results demonstrate that the concept of remission in ADHD has been proposed by several study groups, using thresholds of validated rating scales to indicate syndromic, symptomatic and functional remission. Several studies have demonstrated the achievement of remission in ADHD children utilizing methylphenidate delivered by an osmotic, controlled-release formulation (OROS®) and atomoxetine. However, none has defined a time period over which these criteria must be met for an individual with ADHD to be considered ‘in remission’. Standardized remission criteria in ADHD will provide a tool for assessing the effectiveness of treatments for ADHD, and raise treatment standards.

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Acknowledgements

Drs Ramos-Quiroga and Casas would like to thank Frances Gambling, Medicus International, for her editorial assistance, which included assistance with the literature search and proofreading of the manuscript. Editorial assistance was funded by Janssen-Cilag. Grants were also received from the Department of Health of the Government of Catalonia (Generalitat de Catalonia, Spain) and from Fundación Alícia Koplowitz.

Dr Ramos-Quiroga has received lecture and consulting fees from Janssen-Cilag, Laboratorios Rubió, Shire and Eli Lilly, and research funding from Janssen-Cilag and Laboratorios Rubió. Dr Casas has received lecture and consulting fees from Janssen-Cilag and Laboratorios Rubió, and research funding from Janssen-Cilag.

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  1. Department of Psychiatry, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Passeig Vall d’Hebron no. 119-129, 08035, Barcelona, Spain

    J. Antoni Ramos-Quiroga & Miguel Casas

  2. Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain

    J. Antoni Ramos-Quiroga & Miguel Casas

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  1. J. Antoni Ramos-Quiroga
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Ramos-Quiroga, J.A., Casas, M. Achieving Remission as a Routine Goal of Pharmacotherapy in Attention-Deficit Hyperactivity Disorder. CNS Drugs 25, 17–36 (2011). https://doi.org/10.2165/11538450-000000000-00000

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