Abstract
This review presents current literature on the epidemiology and treatment of social anxiety disorder (social phobia). This illness has been demonstrated to be the most common anxiety disorder with a 1-year prevalence of 7 to 8% and a lifetime prevalence of 13 to 14% in patients aged between 15 and 54 years. Social anxiety disorder can be classified into 2 subtypes, discrete and generalised. Morbidity is high with this disorder, and 70 to 80% of patients have co-morbid mental disorders. Although effective treatments are available, social anxiety disorder is under-recognised and under-treated. Treatments that have been systemically studied and have shown efficacy in patients with social anxiety disorder include pharmacotherapy (selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, reversible inhibitors of monoamine-A and benzodiazepines) and short term psychotherapies (cognitive behaviour therapy, social skills training and exposure in vivo therapy). β-blockers are useful in treating performance-related anxiety. Few published data are available on the treatment of social anxiety disorder with a combination of pharmacotherapy and psychotherapy. We conclude this review by discussing proposed algorithms for treating both subtypes of social anxiety disorder.
Similar content being viewed by others
References
Liebowitz MR, Gorman JM, Fyer AJ, et al. Social phobia: review of a neglected anxiety disorder. Arch Gen Psychiatry 1985; 42: 729–36
Kessler RC, McGonagle KA, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: results from the National Comorbidity Survey. Arch Gen Psychiatry 1994; 51: 8–19
Magee- WJ, Eaton- WW, Wittchen- HU, et al. Agoraphobia, simple phobia, and social phobia in the National Comorbidity Survey. Arch Gen Psychiatry 1996; 53(2): 159–68
Stein MB. How shy is too shy? Lancet 1996; 347: 1131–2
Schneier FR, Johnson J, Hornig CD, et al. Social phobia: comorbidty and morbidity in an epidemiologic sample. Arch Gen Psychiatry 1992; 49: 282–8
Davidson JRT, Hughes DL, George LK, et al. The epidemiology of social phobia: findings from the Duke Epidemiological Catchment Area Study. Psychol Med 1993; 23(3): 709–18
Fones CSL, Gus Manfro G, Pollack. Social phobia: an update. Harv Rev Psychiatry 1998; 5(5): 247–59
Weiller E, Bisserbe JC, Boyer P, et al. Social phobia in general health care: an unrecognized undertreated disabling disorder. Br J Psychiatry 1996: 168: 169–74
Swinson RP, Cox BJ, Woszczyna CB. Use of medical services and treatment for panic disorder with agoraphobia and for social phobia. Can Med Assoc J 1992; 147: 878–83
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington (DC): American Psychiatric Association Inc., 1994
World Health Organization (WHO). The ICD-10 classification of mental and behavioral disorders: clinical descriptions and diagnostic guidelines. Geneva: WHO, 1992
Mannuzza S, Schneier FR, Chapman TF, et al. Generalized social phobia: reliability and validity. Arch Gen Psychol 1995; 52: 230–7
Westenberg HGM. The nature of social anxiety disorder. J Clin Psychol 1998; 59 Suppl. 17: 20–4
Kessler RC, Stein MB, Berglund P. Social phobia subtypes in the National Comorbidity Survey. Am J Psychiatry 1998; 155: 613–9
Regier DA, Farmer ME, Rae DS, et al. Comorbidity of mental disorder with alcohol and other drug abuse: results from the epdiemiolgic catchment area study. JAMA 1990; 20(19): 2511–8
Offord DR, Boyle MH, Campbell D, et al. One year prevalence of psychiatric disorder in ontarians 15 to 64 years of age. Can J Psychiatry 1996; 41: 559–63
Verhulst FC, van der Ende J, Ferdinand RF, et al. The prevalence of DSM-III-R diagnoses in a national sample of Dutch adolescents. Arch Gen Psychiatry 1997; 54(4): 329–36
Wittchen HU, Nelson CB, Lachner G. Prevalence of mental disorders and psychosocial impairments in adolescents and young adults. Psychol Med 1998; 28: 109–26
Stein MB, Walker JR, Forde DR. Setting diagnostic thresholds for social phobia: considerations from a community survey of social anxiety. Am J Psychol 1994; 151: 408–12
den Boer JA. Social phobia: epidemiology, recognition, and treatment. BMJ 1997; 315: 796–800
Amies PL, Gelder MG, Shaw PM. Social phobia: a comparative clinical study. Br J Psychiatry 1983; 142: 174–9
Hazen AL, Stein MB. Clinical phenemonology and comorbidity. In: Stein MB, editor. Social phobia: clinical and research perspectives. Washington (DC): American Psychiatric Press, 1995: 3–41
Davidson JRT, Hughes DC, George LK, et al. The boundary of social phobia: exploring the threshold. Arch Gen Psychiatry 1994; 51: 23–7
Stein M, Walker JR, Forde DR. Public-speaking fears in a community sample: prevalence, impact on functioning, and diagnostic classification. Arch Gen Psychiatry 1996; 53(2): 169–74
Safren SA, Heimberg RG, Brown EJ, et al. Quality of life in social phobia. Depress Anxiety 1996-97; 4(3): 126–33
Lecrubier Y. Comorbidity in social anxiety disorder: impact on disease burden and management. J Clin Psychiatry 1998; 59 Suppl. 7: 33–7
Merikangas KR, Stevens DE, Fenton B, et al. Co-morbidity and familial aggregation of alcoholism and anxiety disorders. Psychol Med 1998; 4: 773–88
Ballenger JC, Davidson JRT, Lecrubier Y, et al. Consensus statement on social anxiety disorder from the international consensus group on depression and anxiety. J Clin Psychiatry 1998; 59 Suppl. 17: 54–60
Davidson JRT. Pharmacotherapy of social anxiety disorder. J Clin Psychiatry 1998; 59 Suppl. 17: 47–51
Stein MB, Liebowitz MR, Lydiard RB, et al. Paroxetine treatment of generalized social phobia (social anxiety disorder): a randomized controlled trial. JAMA 1998; 280: 708–13
Stein MB, Fyer AJ, Davidson RJT, et al. Fluvoxamine in social phobia: a double-blind, placebo-controlled clinical study. Am J Psychiatry 1999; 156:756–60
Stein DJ, Berk M, Els C, et al. A double-blind placebo-controlled trial of paroxetine in the management of social phobia (social anxiety disorder) in South Africa. S Afr Med J 1999; 89: 402–6
Stein MB, Chartier MJ, Hazen AL, et al. Paroxetine in the treatment of generalized social phobia: open-label treatment and double-blind placebo-controlled discontinuation. J Clin Psychopharmacol 1996; 16: 218–22
Van Vliet IM, den Boer JA, Westenberg HG. Psychopharmacological treatment of social phobia: a double blind placebo controlled study with fluvoxamine. Psychopharmacology (Berl) 1994; 115: 128–34
Katzelnick DJ, Kobak KA, Greist JH, et al. Sertraline for social phobia: a double-blind, placebo-controlled cross-over study. Am J Psychiatry 1995; 152: 1368–71
Van Ameringen M, Mancini C, Streiner DL. Fluoxetine efficacy in social phobia. J Clin Psychiatry 1993; 54: 27–32
Lepola U, Koponen H, Leinonen E. Citalopram in the treatment of social phobia: a report of three cases. Pharmacopsychiatry 1994; 27: 186–8
Bouwer C, Stein, DJ. Use of the selective serotonin reuptake inhibitor citalopram in the treatment of generalized social phobia. J Affect Dis 1998; 49(1): 79–82
Montejo-Gonzalez AL, Llorca G, Izquierdo JA, et al. SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther 1997; 23(3): 176–94
Liebowitz MR, Schneier F, Campeas R, et al. Phenelzine vs atenolol in social phobia: a placebo-controlled comparsion. Arch Gen Psychiatry 1992; 49(4): 290–300
Versiani M, Nardi AE, Mundim FD, et al. Pharmacotherapy of social phobia: a controlled study with moclobemide and phenelzine. Br J Psychiatry 1992; 161: 353–60
Heimberg RG, Liebowitz MR, Hope DA, et al. Cognitive behavioral group therapy vs phenelzine therapy for social phobia. Arch Gen Psychiatry 1998; 55: 1133–40
Versiani M, Mundim FD, Nardi AE, et al. Tranylcypromaine in social phobia. J Clin Psychopharmacol 1988; 8: 279–83
Katschnig H, Stein MB, Buller R, on behalf of the International Multicenter Clinical Trial Group on moclobemide in social phobia. Moclobemide in social phobia: a double-blind, placebo-controlled clinical study. Eur Arch Psychiatry Clin Neurosci 1997; 247: 71–80
Blanco C, Liebowitz MR. Dimensional versus categorical response to moclobemide in social phobia. J Clin Psychopharmacol 1998; 18(4): 344–5
Noyes R, Moroz G, Davidson JRT, et al. Moclobemide in social phobia: a controlled dose-response trial. J Clin Psychopharmacol 1997; 17(4) 247–53
Schneier FR, Goetz D, Campeas R, et al. Placebo-controlled trial of moclobemide in social phobia. Br J Psychiatry 1998; 172: 70–7
Duffett R. Moclobemide in social phobia. Br J Psychiatry 1998; 172: 451–2
Lott M, Greist JH, Jefferson JW, et al. Brofaromine for social phobia: a multicenter, placebo-controlled, double-blind study. J Clin Psychopharmacol 1997; 17(4) 255–9
Keck PE, McElroy SL. New uses for antidepressants: social phobia. J Clin Psychiatry 1997; 58 Suppl. 14: 32–6
Emmanuel NP, Lydiard RB, Ballenger JC. Treatment of social phobia with bupropion. J Clin Psychopharmacol 1991; 11(4): 276–7
Simpson BH, Schneier FR, Campeas RB. Imipramine in the treatment of social phobia. J Clin Psychopharmacol 1998; 18(2): 132–5
Davidson JRT, Potts N, Richichi E, et al. Treatment of social phobia with clonazepam and placebo. J Clin Psychopharmacol 1993; 13: 423–8
Gelernter CS, Uhde TW, Cimbolic P, et al. Cognitive-behavioral and pharmacological treatment of social phobia: a controlled study. Arch Gen Psychiatry 1991; 48: 938–45
Sutherland SM, Davidson JRT. β-Blockers and benzodiazepines in pharmacotherapy. In: Stein MB, editor. Social phobia: clinical and research perspectives. Washington (DC): American Psychiatric Press, Inc., 1995
Schneier FR, Saoud JB, Campeas R, et al. Buspirone in social phobia. J Clin Psychopharmacol 1993; 13: 251–6
van Vliet IM, den Boer JA, Westenberg HGM, et al. Clinical effects of buspirone in social phobia: a double-blind placebo-controlled study. J Clin Psychiatry 1997; 58(4): 164–8
Turner SM, Beidel DC, Jacob RG. Social phobia: a comparson of behavior therapy and atenolol. J Consult Clin Psychol 1994; 62: 350–8
James IM, Griffith DN, Pearson RM, et al. Effect of oxprenolol on stage-fright in musicians. Lancet 1977; II: 952–4
Schneier FR. Monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, and other antidepressants in pharmacotherapy. In: Stein MB, editor. Social phobia: clinical and research perspectives. Washington (DC): American Psychiatric Press, Inc., 1995
Versiani M, Amrein R, Montgomery SA. Social phobia: long-term treatment outcome and prediction of response: a moclobemide study. Int Clin Psychopharmacol 1997; 12(5): 239–54
Gabbard GO. Psychodynamic psychiatry in clinical practice: DSM-IV Washington (DC): American Psychiatric Press Inc., 1994
Stravynski A, Greenberg D. The treatment of social phobia: a critical assessment. Acta Psychiatr Scand 1998; 98: 171–81
Taylor S. Meta-analysis of cognitive-behavioral treatments for social phobia. J Behav Ther Exp Psychiatry 1996; 27: 1–9
Juster HR, Heimberg RG. Social phobia: longitudinal course and long-term outcome of cognitive-behavioral treatment. Psychiatr Clin North Am 1995; 18(4): 821–42
Shear MK, Beidel DC. Psychotherapy in the overall management strategy for social anxiety disorder. J Clin Psychiatry 1998; 59 Suppl. 17: 39–44
Acknowledgements
The authors would like to acknowledge Anju Sareen, BSc Pharm, for her careful review of and comments on the manuscript.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sareen, J., Stein, M. A Review of the Epidemiology and Approaches to the Treatment of Social Anxiety Disorder. Drugs 59, 497–509 (2000). https://doi.org/10.2165/00003495-200059030-00007
Published:
Issue Date:
DOI: https://doi.org/10.2165/00003495-200059030-00007