Abstract
Objectives
Autism spectrum disorders (ASD) are among the leading causes of disabilities in children. We examined the annual prevalence and incidence rate of ASD between 2004 and 2015 in children aged 1 to 5 years residing in Manitoba.
Methods
A population-based study was conducted using the Manitoba Population Research Data Repository. The study included children aged 1 to 5 years residing in Manitoba between 2004 and 2015. Standard identification algorithm was used to identify ASD cases from hospital abstracts and medical claims. Annual prevalence and incidence rates were calculated for the overall population and then stratified according to sex, region, and socio-economic status (SES). Multivariable negative binomial regression models, adjusted for sex, region, and SES, were used to examine changes in prevalence and incidence over study years.
Results
Among children aged 1 to 5 years, 1685 ASD cases were diagnosed between 2004 and 2015. The crude ASD prevalence increased from 0.46% in 2004 to 0.97% in 2015 (p = 0.002). The crude incidence rate increased from 0.16% in 2004 to 0.39% in 2015 (p = 0.002). The increase in ASD prevalence and incidence was observed in all subgroups based on sex, region, and SES. The adjusted negative binomial model showed an annual relative risk increase, since 2004, for both prevalence and incidence of 1.69 (95% CI 1.56–1.83) and 1.84 (95% CI 1.62–2.09), respectively.
Conclusion
During the period from 2004 to 2015, both prevalence and incidence rates of diagnosed ASD in preschoolers and toddlers residing in Manitoba increased significantly.
Résumé
Objectifs
Les troubles du spectre de l’autisme (TSA) sont parmi les principales causes de handicap chez les enfants. Nous avons étudié le taux annuel de prévalence et d’incidence des TSA entre les années 2004 et 2015 chez les enfants âgés de 1 à 5 ans résidents du Manitoba.
Méthodes
Une étude basée sur une population a été menée à l’aide du Dépôt de données de recherche en santé des populations du Manitoba. L’étude incluait des enfants âgés de 1 à 5 ans qui résidaient au Manitoba entre 2004 et 2015. Un algorithme d’identification standard a servi à identifier les cas de TSA à partir des résumés hospitaliers et des réclamations au titre de frais médicaux. Les taux annuels de prévalence et d’incidence ont été calculés pour l’ensemble de la population, puis stratifiés en fonction du sexe, de la région et du statut socio-économique. Des modèles multivariables de régression binomiale négative ajustés en fonction du sexe, de la région et du statut socio-économique, ont été utilisés pour examiner les changements dans la prévalence et l’incidence sur la période étudiée.
Résultats
Parmi les enfants âgés de 1 à 5 ans, 1685 cas de TSA ont été diagnostiqués entre 2004 et 2015. Le taux de prévalence brut des TSA est passé de 0,46 % en 2004 à 0,97 % en 2015 (p = 0,002). Le taux d’incidence brut est passé de 0,16 % en 2004 à 0,39 % en 2015 (p = 0,002). L’augmentation de la prévalence et de l’incidence des TSA a été observée dans tous les sous-groupes en fonction du sexe, de la région et du statut socio-économique. Le modèle binomial négatif ajusté a montré une augmentation annuelle du risque relatif, depuis 2004, pour la prévalence et l’incidence respectivement de 1,69 (IC à 95% 1,56 – 1,83) et de 1,84 (IC à 95% 1,62 – 2,09).
Conclusion
Durant la période allant de 2004 à 2015, les taux de prévalence et d’incidence des enfants d’âge préscolaire et des tout-petits résidant au Manitoba chez qui l’on a diagnostiqué des TSA ont considérablement augmenté.
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References
American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders. Fifth. Washington, DC: American Psychiatric Association.
Auyeung, B., Baron-Cohen, S., Ashwin, E., et al. (2009). Fetal testosterone and autistic traits. British Journal of Psychology, 100, 1–22.
Baxter, A. J., Brugha, T. S., Erskine, H. E., et al. (2015). The epidemiology and global burden of autism spectrum disorders. Psychological Medicine, 45, 601–613.
Boukhris, T., Sheehy, O., Mottron, L., et al. (2016). Antidepressant use during pregnancy and the risk of autism spectrum disorder in children. JAMA Pediatrics, 170, 117–124.
Brownell M, De Coster C, Penfold R, et al. (2008) Manitoba Child Health Atlas Update. Winnipeg, MB: Manitoba Centre for Health Policy, community health sciences, faculty of medicine, University of Manitoba.
CDC. Data and statistics|autism spectrum disorder (ASD) | NCBDDD | CDC. Centers for Disease Control and Prevention, https://www.cdc.gov/ncbddd/autism/data.html (2018, accessed 27 June 2018).
Christensen, D. L. (2012). Prevalence and characteristics of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, MMWR Surveillance Summaries 65. Epub ahead of print 2016. https://doi.org/10.15585/mmwr.ss6503a1.
Dodds, L., Spencer, A., Shea, S., et al. (2009). Validity of autism diagnoses using administrative health data. Chronic Diseases in Canada, 29, 102–107.
Duan, G., Yao, M., Ma, Y., et al. (2014). Perinatal and background risk factors for childhood autism in Central China. Psychiatry Research, 220, 410–417.
Elsabbagh, M., Divan, G., Koh, Y.-J., et al. (2012). Global prevalence of autism and other pervasive developmental disorders: global epidemiology of autism. Autism Research, 5, 160–179.
Gardener, H., Spiegelman, D., & Buka, S. L. (2009). Prenatal risk factors for autism: comprehensive meta-analysis. The British Journal of Psychiatry, 195, 7–14.
Gardener, H., Spiegelman, D., & Buka, S. L. (2011). Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis. Pediatrics, 128, 344–355.
Geschwind, D. H. (2011). Genetics of autism spectrum disorders. Trends in Cognitive Sciences, 15, 409–416.
Hallmayer, J. (2011). Genetic heritability and shared environmental factors among twin pairs with autism. Archives of General Psychiatry, 68, 1095.
Hattier, M. A., Matson, J. L., Tureck, K., et al. (2011). The effects of gender and age on repetitive and/or restricted behaviors and interests in adults with autism spectrum disorders and intellectual disability. Research in Developmental Disabilities, 32, 2346–2351.
Hoshino, Y., Kumashiro, H., Yashima, Y., et al. (1982). The epidemiological study of autism in Fukushima-ken. Folia Psychiatrica et Neurologica Japonica, 36, 115–124.
Kanner, L. (1943). Autistic disturbances of affective contact. The Nervous Child, 2, 217–250.
Lauritsen, M. B., Pedersen, C. B., & Mortensen, P. B. (2005). Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study. Journal of Child Psychology and Psychiatry, 46, 963–971.
Lauritsen, M. B., Astrup, A., Pedersen, C. B., et al. (2014). Urbanicity and autism spectrum disorders. Journal of Autism and Developmental Disorders, 44, 394–404.
Mandy, W., Chilvers, R., Chowdhury, U., et al. (2012). Sex differences in autism spectrum disorder: evidence from a large sample of children and adolescents. Journal of Autism and Developmental Disorders, 42, 1304–1313.
Mezzacappa, A., Lasica, P.-A., Gianfagna, F., et al. (2017). Risk for autism spectrum disorders according to period of prenatal antidepressant exposure: a systematic review and meta-analysis. JAMA Pediatrics, 171, 555–563.
Ofner M, Coles A, Decou M, et al. (2018) Autism Spectrum Disorder among Children and Youth in Canada 2018: A Report of the National Autism Spectrum Disorder Surveillance System. Ottawa, ON: Public Health Agency of Canada, https://www.canada.ca/en/public-health/services/publications/diseases-conditions/autism-spectrum-disorder-children-youth-canada-2018.html#fig1 (March 2018, accessed 22 May 2018).
Reinhardt, V. P., Wetherby, A. M., Schatschneider, C., et al. (2015). Examination of sex differences in a large sample of young children with autism spectrum disorder and typical development. Journal of Autism and Developmental Disorders, 45, 697–706.
Rosenberg, R. E., Daniels, A. M., Law, J. K., et al. (2009). Trends in autism spectrum disorder diagnoses: 1994-2007. Journal of Autism and Developmental Disorders, 39, 1099–1111.
Solomon, M., Miller, M., Taylor, S. L., et al. (2012). Autism symptoms and internalizing psychopathology in girls and boys with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42, 48–59.
Vehling, L., Brownell, M., Kaufert, J., et al. (2016). Children with autism spectrum disorder in Manitoba: prevalence, population characteristics and psychotropic medication use. Health Promotion and Chronic Disease Prevention in Canada, 36, 270.
Werling, D. M., & Geschwind, D. H. (2013). Sex differences in autism spectrum disorders. Current Opinion in Neurology, 26, 146–153.
Wing, L., & Potter, D. (2002). The epidemiology of autistic spectrum disorders: is the prevalence rising? Mental Retardation and Developmental Disabilities Research Reviews, 8, 151–161.
Wong, V. C. N., & Hui, S. L. H. (2008). Epidemiological study of autism spectrum disorder in China. Journal of Child Neurology, 23, 67–72.
Yeargin-Allsopp, M., Rice, C., Karapurkar, T., et al. (2003). Prevalence of autism in a US metropolitan area. JAMA, 289, 49–55.
Acknowledgements
We would like to thank Charles Burchill and Heather Prior from the Manitoba Centre for Health Policy for their valuable support. The authors acknowledge the Manitoba Centre for Health Policy for use of data contained in the Manitoba Population Research Data Repository under project #H2016:244 (HIPC# 2016/2017 – 11). The results and conclusions are those of the authors and no official endorsement by the Manitoba Centre for Health Policy, Manitoba Health, Healthy Living and Seniors or other data providers is intended or should be inferred. Data used in this study are from the Manitoba Population Research Data Repository housed at the Manitoba Centre for Health Policy, University of Manitoba and were derived from data provided by Manitoba Health, Healthy Living and Seniors.
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Hamad, A.F., Alessi-Severini, S., Mahmud, S.M. et al. Annual trends in prevalence and incidence of autism spectrum disorders in Manitoba preschoolers and toddlers: 2004–2015. Can J Public Health 110, 476–484 (2019). https://doi.org/10.17269/s41997-019-00181-9
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DOI: https://doi.org/10.17269/s41997-019-00181-9