Skip to main content
SpringerLink
Log in

An overview of studies on psychological well-being in children born following assisted reproductive technologies

  • Review
  • Published:
Journal of Zhejiang University SCIENCE B Aims and scope Submit manuscript

Abstract

Over the course of the past 35 years, assisted reproductive technologies (ARTs) have been increasingly used worldwide, while debates on their safety have been generated. Birth defects and imprinting disorders were reported in previous research. Thus, the psychological development of children born following ARTs has become a major concern nowadays. This review gives a systematic view of psychological well-being of children conceived by different types of ART, including in vitro fertilization, intracytoplasmic sperm injection (ICSI), preimplantation genetic diagnosis/screening, and in vitro maturation. The previous studies are analyzed in three sections: (1) cognitive, motor, and language developments, (2) behavior problems and socio-emotional development, and (3) parent-child relationship. We conclude that although the majority of the studies on cognitive, motor, and language developments reported comparable achievements in the ART group vs. the naturally conceived group, lower intelligence quotient (IQ) scores, worse visual-motor ability or locomotor development, and delayed receptive language competence were found in the ART group. The results on the socio-emotional development were reassuring. As for the behavior problems, a higher prevalence of behavior problems existed in ART children; moreover, ICSI children were found to be at a higher risk of autism than the general population. Meanwhile, ART parents tended to have positive parental attitudes and be more protective of their children. Some suggestions for further research are also given in this review.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Abidin, R., 1990. Parenting Stress Index Test Manual. Pediatric Psychology Press, Charlottesville, Virginia.

    Google Scholar 

  • Achenbach, T.M., 1991a. Manual for the Child Behavior Checklist/4-18 and 1991 Profiles. Department of Psychiatry, University of Vermont, Burlington, Vermont.

    Google Scholar 

  • Achenbach, T.M., 1991b. Manual for the Youth Self-Report and 1991 Profiles. Department of Psychiatry, University of Vermont, Burlington, Vermont.

    Google Scholar 

  • Achenbach, T.M., Edelbrock, C., 1983. Manual for the Child Behavior Checklist and Revised Child Behavior Profile. Department of Psychiatry, University of Vermont, Burlington, Vermont.

    Google Scholar 

  • Achenbach, T.M., Rescorla, L.A., 2000. Manual for ASEBA Preschool Forms & Profiles. Research Center for Children, Youth, & Families, University of Vermont, Burlington, Vermont.

    Google Scholar 

  • Achenbach, T.M., Rescorla, L.A., 2001. Manual of the ASEBA School-Age Forms & Profiles. Research Center for Children, Youth & Families, University of Vermont, Burlington, Vermont.

    Google Scholar 

  • Ainsworth, M., Blehar, M.C., Waters, E.C., Wall, S., 1978. The Strange Situation. Lawrence Erlbaum, Oxford, England.

    Google Scholar 

  • Armsden, G.C., Greenberg, M.T., 1987. The inventory of peer and parent attachment: individual differences and their relationship to psychological well-being in adolescence. J. Youth Adolesc., 16(5):427–454. [doi:10.1007/BF02202939]

    Google Scholar 

  • Banerjee, I., Shevlin, M., Taranissi, M., Thornhill, A., Abdalla, H., Ozturk, O., Barnes, J., Sutcliffe, A., 2008. Health of children conceived after preimplantation genetic diagnosis: a preliminary outcome study. Reprod. Biomed. Online, 16(3):376–381. [doi:10.1016/S1472-6483(10)60599-8]

    PubMed  CAS  Google Scholar 

  • Barnes, J., Sutcliffe, A.G., Kristoffersen, I., Loft, A., Wennerholm, U., Tarlatzis, B.C., Kantaris, X., Nekkebroeck, J., Hagberg, B.S., Madsen, S.V., et al., 2004. The influence of assisted reproduction on family functioning and children’s socio-emotional development: results from a European study. Hum. Reprod., 19(6):1480–1487. [doi:10.1093/humrep/deh239]

    PubMed  CAS  Google Scholar 

  • Basatemur, E., Sutcliffe, A., 2008. Follow-up of children born after ART. Placenta, 29:S135–S140. [doi:10.1016/j. placenta.2008.08.013]

    Google Scholar 

  • Bayley, N., 1993. Bayley Scales of Infant Development, 2nd Ed. Harcourt Brace and Company, San Antonio, p.374.

    Google Scholar 

  • Beery, K.E., 1989. Developmental Tests of Visual-Motor Integration with Supplemented Developmental Test of Visual Perception and Motor Coordination. Modern Curriculum Press, Cleveland, Ohio.

    Google Scholar 

  • Beery, K.E., Buktenica, N.A., 1989. The VMI Developmental Test of Visual-Motor Integration. Modern Curriculum Press, Cleveland, Ohio.

    Google Scholar 

  • Bene, E., Anthony, J., 1985. Manual for the Family Relations Test. NFER-Nelson, Windsor, UK.

    Google Scholar 

  • Benjamin, J.S., Virginia, A.S., Pedro, R., 2009. Normal Child Development. Lippincott Williams & Wilkins, Philadelphia.

    Google Scholar 

  • Biringen, Z., Robinson, J., Emde, R.N., 1993. Emotional Availability Scales, 2nd Ed. Department of Human Development and Family Studies, Colorado State University, Fort Collins.

    Google Scholar 

  • Bleichrodt, N., Resing, W.C.M., Drenth, P.J.D., Zaal, J.N., 1987. Intelligentie-Meting Bij Kinderen: Empirische en Methodologische Verantwoording van de GeReviseerde Amsterdamse Kinder Intelligentie Test. Swets & Zeitlinger, Lisse, the Netherlands (in Dutch).

    Google Scholar 

  • Bzoch, K.R., League, R., 1991. Receptive-Expressive Emergent Language Test, 2nd Ed. Examiner’s Manual. PRO-ED, Austin, p.48.

    Google Scholar 

  • Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology, 2010. 2008 Assisted Reproductive Technology Success Rates: National Summary and Fertility Clinic Reports. Department of Health and Human Services, Atlanta.

    Google Scholar 

  • Chang, A.S., Moley, K.H., Wangler, M., Feinberg, A.P., DeBaun, M.R., 2005. Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients. Fertil. Steril., 83(2): 349–354. [doi:10.1016/j.fertnstert.2004.07.964]

    PubMed  Google Scholar 

  • Colpin, H., Soenen, S., 2002. Parenting and psychosocial development of IVF-children. A follow-up study. Hum. Reprod., 17(4):1116–1123. [doi:10.1093/humrep/17.4.1116]

    PubMed  CAS  Google Scholar 

  • Colpin, H., Bossaert, G., 2008. Adolescents conceived by IVF: parenting and psychosocial adjustment. Hum. Reprod., 23(12):2724–2730. [doi:10.1093/humrep/den297]

    PubMed  CAS  Google Scholar 

  • Colpin, H., Demyttenaere, K., Vandemeulebroecke, L., 1995. New reproductive technology and the family. The parent-child relationship following in vitro fertilization. J. Child Psychol. Psyc., 36(8):1429–1441. [doi:10.1111/j.1469-7610.1995.tb01673.x]

    CAS  Google Scholar 

  • Cousineau, T.M., Domar, A.D., 2007. Psychological impact of infertility. Best Pract. Res. Clin. Obstet. Gynaecol., 21(2): 293–308. [doi:10.1016/j.bpobgyn.2006.12.003]

    PubMed  Google Scholar 

  • Cox, G.F., Bürger, J., Lip, V., Mau, U.A., Sperling, K., Wu, B.L., Horsthemke, B., 2002. Intracytoplasmic sperm injection may increase the risk of imprinting defects. Am. Soc. Hum. Genet., 71(1):162–164. [doi:10.1086/341096]

    CAS  Google Scholar 

  • DeBaun, M.R., Niemitz, L., Feinberg, A.P., 2003. Association of in vitro fertilization with Beckwith-Wiedemann Syndrome and epigenetic alterations of LIT1 and H19. Am. J. Hum. Genet., 72(1):156–160. [doi:10.1086/346031]

    PubMed  CAS  Google Scholar 

  • de Graaf-Peters, V.B., Hadders-Algra, M., 2006. Ontogeny of the human central nervous system: what is happening when?. Early Hum. Dev., 82(4):257–266. [doi:10.1016/j.earlhumdev.2005.10.013]

    PubMed  Google Scholar 

  • de Sonneville, L.M.J., 1999. Amsterdam Neuropsychological Tasks: A Computer-Aided Assessment Program. In: DenBrinker, B.P.L.M., Beek, P.J., Brand, A.N., Maarse, F.J., Mulder, L.J.M. (Eds.), Cognitive Ergonomics, Clinical Assessment and Computer-Assisted Learning: Computers in Psychology. Swets & Zeitlinger, Lisse, the Netherlands, p.187–203.

    Google Scholar 

  • Derogatis, L.R., 1994. SCL-90-R Symptoms Check List: Administration, Scoring and Procedures Manual. National Computoer Systems, Minneapolis, Minnesota.

    Google Scholar 

  • Duncan, S., Edwards, D., 1999. Lone Mothers, Paid Work and Gendered Moral Rationalities. Palgrave Macmillan Publishers Ltd., Basingstoke, UK. [doi:10.1057/9780230 509689]

    Google Scholar 

  • Engfer, A., Schneewind, K.A., 1976. Ein Fragebogen Selbstperzipiertes Elterlichen Erziehungseinstellungen. Trier University, Trier, Germany (in German).

    Google Scholar 

  • Erickson, M., Sroufe, L.A., Egeland, B., 1985. The Relationship Between Quality of Attachment and Behavior Problems in Preschool in a High Risk Sample. University of Chicago Press, Chicago.

    Google Scholar 

  • Fauser, B.C., Devroey, P., Macklon, N.S., 2005. Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet, 365(9473):1807–1816. [doi:10.1016/S0140-6736(05)66478-1]

    PubMed  Google Scholar 

  • Folio, M.R., Fewell, R.R., 2000. Peabody Developmental Motor Scales, 2nd Ed. PRO-ED, Austin, Texas.

    Google Scholar 

  • Gerris, J.R.M., Vermulst, A.A., Boxtel, D.A.A.M., van Janssens, J.M.A.M., van Zutphen, R.A.H., Felling, A.J.A., 1993. Parenting in Dutch Families: A Representative Description of Dutch Family Life in Terms of Validated Concepts Representing Characteristics of Parents, Children, the Family as a System and Parental Socio-cultural Value Orientations. Institute of Family Studies, University of Nijmegen, Nijmegen, the Netherlands.

    Google Scholar 

  • Gerris, L.A.W., Dekovic, M., Groenendaal, J.H.A., Noom, M.J., 1996. Parenting Behavior. In: Rispens, J., Hermanns, J.M.A., Meeus, W.H.J. (Eds.), Childrearing in the Netherlands. van Gorcum, Assen, p.41–69.

    Google Scholar 

  • Gibson, F.L., Ungerer, J.A., Leslie, G.I., Saunders, D.M., Tennant, C.C., 1998. Development, behaviour and temperament: a prospective study of infants conceived through in-vitro fertilization. Hum. Reprod., 13(6): 1727–1732. [doi:10.1093/humrep/13.6.1727]

    PubMed  CAS  Google Scholar 

  • Gibson, F.L., Ungerer, J.A., McMahon, C.A., Leslie, G.I., Saunders, D.M., 2000. The mother-child relationship following in vitro fertilisation (IVF): infant attachment, responsivity, and maternal sensitivity. J. Child Psychol. Psychiatry, 41(8):1015–1023. [doi:10.1111/1469-7610.00689]

    PubMed  CAS  Google Scholar 

  • Gicquel, C., Gaston, V., Mandelbaum, J., Siffroi, J.P., Flahault, A., le Bouc, Y., 2003. In vitro fertilisation may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCNQ1OT gene. Am. J. Hum. Genet., 72(5):1338–1341. [doi:10.1086/374824]

    PubMed  CAS  Google Scholar 

  • Golombok, S., Cook, R., Bish, A., Murray, C., 1995. Families created by the new reproductive technologies: quality of parenting and social and emotional development of the children. Child Dev., 66(2):285–298. [doi:10.2307/113 1578]

    PubMed  CAS  Google Scholar 

  • Golombok, S., Brewaeys, A., Cook, R., Giavazzi, M.T., Guerra, D., Mantovani, A., van Hall, E., Crosignani, P.G., Dexeus, S., 1996. The European study of assisted reproduction families: family functioning and child development. Hum. Reprod., 11(10):2324–2331. [doi:10.1093/oxfordjournals.humrep.a019098]

    PubMed  CAS  Google Scholar 

  • Golombok, S., MacCallum, F., Goodman, E., 2001. The “test-tube” generation: parent-child relationships and the psychological well-being of in vitro fertilization children at adolescence. Child Dev., 72(2):599–608. [doi:10.1111/1467-8624.00299]

    PubMed  CAS  Google Scholar 

  • Golombok, S., Brewaeys, A., Giavazzi, M.T., Guerra, D., MacCallum, F., Rust, J., 2002. The European study of assisted reproduction families: the transition to adolescence. Hum. Reprod., 17(3):830–840. [doi:10.1093/humrep/17.3.830]

    PubMed  CAS  Google Scholar 

  • Golombok, S., Owen, L., Blake, L., Murray, C., Jadva, V., 2009. Parent-child relationships and the psychological well-being of 18-year-old adolescents conceived by in vitro fertilisation. Hum. Fertil., 12(2):63–72. [doi:10.1080/14647270902725513]

    Google Scholar 

  • Goodman, R., 1994. A modified version of the Rutter Parent Questionnaire including extra items on children’s 608 child development strengths: a research note. J. Child Psychol. Psychiatry, 35(8):1483–1494. [doi:10.1111/j. 1469-7610.1994.tb01289.x]

    PubMed  CAS  Google Scholar 

  • Goodman, R., 1997. The Strengths and Difficulties Questionnaire: a research note. J. Child Psychol. Psychiatry, 38(5):581–586. [doi:10.1111/j.1469-7610.1997.tb01545.x]

    PubMed  CAS  Google Scholar 

  • Graham, P., Rutter, M., 1968. The reliability and validity of the psychiatric assessment of the child: II. Interview with the parent. Br. J. Psychiatry, 114(510):581–592. [doi:10.1192/bjp.114.510.581]

    PubMed  CAS  Google Scholar 

  • Griffiths, R., 1996. The Griffiths Mental Development Scales 1996. Association for Research in Infant and Child Development, the Test Agency, UK.

    Google Scholar 

  • Halliday, J., Oke, K., Breheny, S., Algar, E., Amor, D.J., 2004. Beckwith-Wiedemann syndrome and IVF: a case-control study. Am. J. Hum. Genet., 75(3):526–528. [doi:10.1086/423902]

    PubMed  CAS  Google Scholar 

  • Harter, S., Pike, R., 1984. The pictorial scale of perceived competence and social acceptance for young children. Child Dev., 55(6):1969–1982. [doi:10.2307/1129772]

    PubMed  CAS  Google Scholar 

  • Helmerhorst, F.M., Perquin, D.A.M., Donker, D., Keirse, M.J.N.C., 2004. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ, 328(7434):261–265. [doi:10.1136/bmj.37957.560278.EE]

    PubMed  Google Scholar 

  • Henderson, S.E., Sugden, D.A., 1998. Movement Assessment Battery for Children. Handleiding. Swets & Zeitlinger B.V., Lisse, the Netherlands.

    Google Scholar 

  • Hetherington, E.M., 1992. Coping with marital transitions: a family system perspective. Monogr. Soc. Res. Child Dev., 57(2–3):1–14. [doi:10.1111/j.1540-5834.1992.tb00300.x]

    Google Scholar 

  • Huntley, M., 1996. The Griffiths Mental Development Scales. 1996 Revision, the Test Agency, Henley, UK.

    Google Scholar 

  • Izat, Y., Goldbeck, L., 2008. The development of children from assisted reproduction—a review of the literature. Prax. Kinderpsychol. Kinderpsychiatr., 57(4):264–281 (in German).

    PubMed  Google Scholar 

  • Jackson, R.A., Gibson, K.A., Wu, Y.W., Croughan, M.S., 2004. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet. Gynecol., 103(3): 551–563. [doi:10.1097/01.AOG.0000114989.84822.51]

    PubMed  Google Scholar 

  • John, K., Quinton, D., 1991. Child and Adolescent Functioning and Environment Schedule (Revised). MRC Child Psychiatry Unit, London.

    Google Scholar 

  • John, K., Gammon, G.D., Prusoff, B.A., Warner, V., 1987. The Social Adjustment Inventory for Children and Adolescents (SAICA): testing of a new semistructured interview. J. Am. Acad. Child Adolesc. Psychiatry, 26(6):898–911. [doi:10.1097/00004583-198726060-00015]

    PubMed  CAS  Google Scholar 

  • Josse, D., 1997. Brunet-Lézine Révisé: Echelle de Developpement Psychomoteur de la Première Enfance. Issy-Les-Moulineaux, EAP, France (in French).

    Google Scholar 

  • Kaufman, A.S., 2001. Kaufman Assessment Battery for Children, Deutsche Version. Leiden University, Leiden.

    Google Scholar 

  • Knoester, M., Helmerhorst, F.M., van der Westerlaken, L.A.J., Walther, F.J., Veen, S., 2007. Matched follow-up study of 5–8-year-old-ICSI singletons: child behaviour, parenting stress and child (health-related) quality of life. Hum. Reprod., 22(12):3098–3107. [doi:10.1093/humrep/dem261]

    PubMed  CAS  Google Scholar 

  • Knoester, M., Helmerhorst, F.M., Vandenbroucke, J.P., van der Westerlaken, L.A.J., Walther, F.J., Veen, S., 2008. Cognitive development of singletons born after intracytoplasmic sperm injection compared with in vitro fertilization and natural conception. Fertil. Steril., 90(2): 289–296. [doi:10.1016/j.fertnstert.2007.06.090]

    PubMed  Google Scholar 

  • Koivurova, S., Hartikainen, A., Sovio, U., Gissler, M., Hemminki, E., Järvelin, M.R., 2003. Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Hum. Reprod., 18(11):2328–2336. [doi:10.1093/humrep/deg445]

    PubMed  CAS  Google Scholar 

  • Leslie, G.I., Gibson, F.L., McMahon, C., Cohen, J., Saunders, D.M., Tennant, C., 2003. Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age. Hum. Reprod., 18(10): 2067–2072. [doi:10.1093/humrep/deg408]

    PubMed  CAS  Google Scholar 

  • Leunens, L., Celestin-Westreich, S., Bonduelle, M., Liebaers, I., Ponjaert-Kristoffersen, I., 2006. Cognitive and motor development of 8-year-old children born after ICSI compared to spontaneously conceived children. Hum. Reprod., 21(11):2922–2929. [doi:10.1093/humrep/del266]

    PubMed  CAS  Google Scholar 

  • Leunens, L., Celestin-Westreich, S., Bonduelle, M., Liebaers, I., Ponjaert-Kristoffersen, I., 2008. Follow-up of cognitive and motor development of 10-year-old singleton children born after ICSI compared with spontaneously conceived children. Hum. Reprod., 23(1):105–111. [doi:10.1093/humrep/dem257]

    PubMed  CAS  Google Scholar 

  • Lu, Y.H., Wang, N., Jin, F., 2013. Long-term follow-up of children conceived through assisted reproductive technology. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 14(5):359–371. [doi:10.1631/jzus.B1200348]

    Google Scholar 

  • Ludwig, A.K., Katalinic, A., Thyen, U., Sutcliffe, A.G., Diedrich, K., Ludwig, M., 2009a. Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany. Fertil. Steril., 91(1):125–132. [doi:10.1016/j.fertnstert.2007.11.030]

    PubMed  Google Scholar 

  • Ludwig, A.K., Katalinic, A., Entenmann, A., Thyen, U., Sutcliffe, A.G., Diedrich, K., Ludwig, M., 2009b. Can we sense ART? The blinded examiner is not blind—a problem with follow-up studies on children born after assisted reproduction. Fertil. Steril., 992 (3):950–952. [doi:10.1016/j.fertnstert.2009.01.086]

    PubMed  Google Scholar 

  • Maher, E.R., Brueton, L.A., Bowdin, S.C., Luharia, A., Cooper, W., Cole, T.R., Macdonald, F., Sampson, J.R., Barratt, C.L., Reik, W., et al., 2003. Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). J. Med. Genet., 40(1):62–64. [doi:10.1136/jmg.40.1.62]

    PubMed  CAS  Google Scholar 

  • McCarthy, D., 1972. Manual for the McCarthy Scales of Children’s Abilities. Psychological Corporation, New York.

    Google Scholar 

  • Middelburg, K.J., Heineman, M.J., Bos, A.F., Hadders-Algra, M., 2008. Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI: a systematic review. Hum. Reprod. Update, 14(3):219–231. [doi:10.1093/humupd/dmn005]

    PubMed  CAS  Google Scholar 

  • Mu, S.C., Hwang, J.L., Lin, Y.H., Sung, T.C., Lin, M.I., Yeh, T.F., 2006. Growth and development of children conceived by in-vitro maturation of human oocytes. Early Hum. Dev., 82(10):677–682. [doi:10.1016/j.earlhumdev. 2006.01.012]

    Google Scholar 

  • Neemann, J., Harter, S., 1986. Manual of the Self-perception Profile for College Students. University of Denver, Denver.

    Google Scholar 

  • Nekkebroeck, J., Bonduelle, M., Desmyttere, S., van den Broeck, W., Ponjaert-Kristoffersen, I., 2008a. Mental and psychomotor development of 2-year-old children born after preimplantation genetic diagnosis/screening. Hum. Reprod., 23(7):1560–1566. [doi:10.1093/humrep/den033]

    PubMed  Google Scholar 

  • Nekkebroeck, J., Bonduelle, M., Desmyttere, S., van den Broeck, W., Ponjaert-Kristoffersen, I., 2008b. Socio-emotional and language development of 2-year-old children born after PGD/PGS, and parental well-being. Hum. Reprod., 23(8):1849–1857. [doi:10.1093/humrep/den179]

    PubMed  Google Scholar 

  • Owen, L., Golombok, S., 2009. Families created by assisted reproduction: parent-child relationships in late adolescence. J. Adolesc., 32(4):835–848. [doi:10.1016/j.adolescence.2008.10.008]

    PubMed  Google Scholar 

  • Papaligoura, Z., Panopoulou-Maratou, O., Solman, M., Arvaniti, K., Sarafidou, J., 2004. Cognitive development of 12 month old Greek infants conceived after ICSI and the effects of the method on their parents. Hum. Reprod., 19(6):1488–1493. [doi:10.1093/humrep/deh270]

    PubMed  Google Scholar 

  • Place, I., Englert, Y., 2003. A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and by in vitro fertilization. Fertil. Steril., 80(6):1388–1397. [doi:10.1016/j.fertnstert. 2003.06.004]

    PubMed  Google Scholar 

  • Ponjaert-Kristoffersen, I., Tjus, T., Nekkebroeck, J., Squires, J., Verté, D., Heimann, M., Bonduelle, M., Palermo, G., Wennerholm, U.B., 2004. Psychological follow-up study of 5-year-old ICSI children. Hum. Reprod., 19(12): 2791–2797. [doi:10.1093/humrep/deh511]

    PubMed  CAS  Google Scholar 

  • Ponjaert-Kristoffersen, I., Bonduelle, M., Barnes, J., Nekkebroeck, J., Loft, A., Wennerholm, U.B., Tarlatzis, B.C., Peters, C., Hagberg, B.S., Berner, A., et al., 2005. International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments. Pediatrics, 115(3): E283–E289. [doi:10.1542/peds.2004-1445]

    PubMed  CAS  Google Scholar 

  • Quinton, D., Rutter, M., 1988. Parenting Breakdown: The Making and Breaking of Intergenerational Links. Avebury Gower Publishing, Aldershot, UK.

    Google Scholar 

  • Reitan, R.M., 1979. Trail Making Test: TMT. Testzentrale, Germany.

    Google Scholar 

  • Richman, N., Stevenson, J., Graham, P.J., 1982. Pre-school to School: A Behavioural Study. Academic Press, London, p.225.

    Google Scholar 

  • Rohner, R.P., 1999. Handbook for the Study of Parental Acceptance and Rejection. University of Connecticut, Storrs, Connecticut.

    Google Scholar 

  • Rohner, R.P., Khaleque, A., 2005. Handbook for the Study of Parental Acceptance and Rejection. Rohner Research, Storrs, Connecticut.

    Google Scholar 

  • Rutter, M., Tizard, J., Whitmore, K., 1970. Education, Health and Behaviour. Longman, London.

    Google Scholar 

  • Rutter, M., Cox, A., Tupling, C., Berger, M., Yule, W., 1975. Attainment and adjustment in two geographical areas—the prevalence of psychiatric disorder. Br. J. Psychiatry, 126(6):493–509. [doi:10.1192/bjp.126.6.493]

    PubMed  CAS  Google Scholar 

  • Schieve, L.A., Meikle, S.F., Ferre, C., Peterson, H.B., Jeng, G., Wilcox, L.S., 2002. Low and very low birth weight in infants conceived with use of assisted reproductive technology. N. Engl. J. Med., 346(10):731–737. [doi:10.1056/NEJMoa010806]

    PubMed  Google Scholar 

  • Soenens, B., Beyers, W., Vansteenkiste, M., Sierens, E., Luyckx, K., Goossens, L., 2004. The “Gross Anatomy” of Parenting Styles in Adolescence: Three or Four Dimensions? 18th Biennial Meeting of the International Society for the Study of Behavioural Development (ISSBD), Ghent, Belgium.

    Google Scholar 

  • Sparrow, S.S., Balla, D.A., Cicchetti, D.V., 1984. Vineland Adaptive Behavior Scales. American Guidance Service, Circle Pines, Minnesota.

    Google Scholar 

  • Steptoe, P., Edwards, R., 1978. Birth after the reimplantation of a human embryo. Lancet, 312(8085):366. [doi:10.1016/S0140-6736(78)92957-4]

    Google Scholar 

  • Straus, M., 1979. Measuring intrafamily conflict and violence: the Conflict Tactics (CT) Scales. J. Marr. Fam., 41(1): 75–88. [doi:10.2307/351733]

    Google Scholar 

  • Straus, M., 1980. Victims and aggressors in marital violence. Am. Behav. Sci., 23(5):681–704. [doi:10.1177/000276428002300505]

    Google Scholar 

  • Sutcliffe, A.G., Taylor, B., Li, J., Thornton, S., Grudzinskas, J.G., Lieberman, B.A., 1999. Children born after intracytoplasmic sperm injection: population control study. BMJ, 318(7185):704–705. [doi:10.1136/bmj.318.7185.704]

    PubMed  CAS  Google Scholar 

  • Sutcliffe, A.G., Taylor, B., Saunders, K., Thornton, S., Lieberman, B.A., Grudzinskas, J.G., 2001. Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study. Lancet, 357(9274):2080–2084. [doi:10.1016/S0140-6736 (00)05180-1]

    PubMed  CAS  Google Scholar 

  • Sutcliffe, A.G., Saunders, K., McLachlan, R., Taylor, B., Edwards, P., Grudzinskas, G., Lieberman, B.A., Thornton, S., 2003. A retrospective case-control study of developmental and other outcomes in a cohort of Australian children conceived by intracytoplasmic sperm injection compared with a similar group in the United Kingdom. Fertil. Steril., 79(3):512–516. [doi:10.1016/S0015-0282(02)04701-5]

    PubMed  Google Scholar 

  • Sutcliffe, A.G., Peters, C.J., Bowdin, S., Temple, K., Reardon, W., Wilson, L., Clayton-Smith, J., Brueton, L.A., Bannister, W., Maher, E.R., 2006. Assisted reproductive therapies and imprinting disorders—a preliminary British survey. Hum. Reprod., 221 (4):1009–1011. [doi:10.1093/humrep/dei405]

    PubMed  CAS  Google Scholar 

  • Theunissen, N.C.M., Vogels, T.G.C., Koopman, H.M., Verrips, G.H., Zwinderman, K.A., Verloove-Vanhorick, S.P., Wit, J.M., 1998. The proxy problem: child report versus parent report in health-related quality of life research. Qual. Life Res., 7(5):387–397. [doi:10.1023/A:1008801802877]

    PubMed  CAS  Google Scholar 

  • van der Meulen, B., Ruiter, S., Spelberg, H., Smrkovsky, M., 2002. Bayley Scales of Infant Development-II. Dutch Version of the BSID-II, Specific Dutch Norms Included. Nederlandse Versie, the Netherlands.

    Google Scholar 

  • van der Steene, G., van Haasen, P.P., de Bruyn, E.E.J., Coetsier, P., Pijl, Y.L., Poortinga, Y.H., Spelberg, H.C., Spoelders-Claes, R., Stinissen, J., 1986. Wechsler Intelligence Scale for Children-Revised (English Version). Swets & Zeitlinger B.V., Lisse, the Netherlands.

    Google Scholar 

  • Verhulst, C., van der Ende, J., Koot, H.M., 1996. Handbook of CBCL/4-18 (Netherland Version). Erasmus University Rotterdam, the Netherlands.

    Google Scholar 

  • Verrips, G.H.W., Vogels, T.G.C., Koopman, H.M., Theunissen, N.C.M., Kamphuis, R.P., Fekkes, M.I.N.N., Wit, J.M., Verloove-Vanhorick, S.P., 1999. Measuring health-related quality of life in a child population. Eur. J. Public Health, 9(3):188–193. [doi:10.1093/eurpub/9.3.188]

    Google Scholar 

  • Vogels, T., Verrips, G.H., Verloove-Vanhorick, S.P., Fekkes, M., Kamphuis, R.P., Koopman, H.M., Theunissen, N.C., Wit, J.M., 1998. Measuring health-related quality of life in children: the development of the TACQOL parent form. Qual. Life Res., 7(5):457–465. [doi:10.1023/A:10088 48218806]

    PubMed  CAS  Google Scholar 

  • Wagenaar, K., Huisman, J., Cohen-Kettenis, P.T., Delemarrevan de Waal, H.A., 2008a. An overview of studies on early development cognition, and psychosocial well-being in children born after in vitro fertilization. J. Dev. Behav. Pediatr., 29(3):219–230. [doi:10.1097/DBP.0b013e31817 3a575]

    PubMed  Google Scholar 

  • Wagenaar, K., Ceelen, M., van Weissenbruch, M.M., Knol, D.L., Delemarre-van de Waal, H.A., Huisman, J., 2008b. School functioning in 8- to 18-year-old children born after in vitro fertilization. Eur. J. Pediatr., 167(11):1289–1295. [doi:10.1007/s00431-008-0677-2]

    PubMed  Google Scholar 

  • Wagenaar, K., van Weissenbruch, M.M., Knol, D.L., Cohen-Kettenis, P.T., Delemarre-van de Waal, H.A., Huisman, J., 2009a. Behavior and socioemotional functioning in 9–18-year-old children born after in vitro fertilization. Fertil. Steril., 92(6):1907–1914. [doi:10.1016/j.fertnstert. 2008.09.026]

    PubMed  Google Scholar 

  • Wagenaar, K., van Weissenbruch, M.M., Knol, D.L., Cohen-Kettenis, P.T., Delemarre-van de Waal, H.A., Huisman, J., 2009b. Information processing, attention and visual-motor function of adolescents born after in vitro fertilization compared with spontaneous conception. Hum. Reprod., 24(4):913–921. [doi:10.1093/humrep/den455]

    PubMed  CAS  Google Scholar 

  • Wagenaar, K., van Weissenbruch, M.M., van Leeuwen, F.E., Cohen-Kettenis, P.T., Delemarre-van de Waal, H.A., Schats, R., Huisman, J., 2011. Self-reported behavioral and socioemotional functioning of 11- to 18-year-old adolescents conceived by in vitro fertilization. Fertil. Steril., 95(2):611–616. [doi:10.1016/j.fertnstert.2010.04.076]

    PubMed  Google Scholar 

  • Wechsler, D., 1974. Wechsler Intelligence Scale for Children-Revised: Manual. The Psychological Corporation, New York.

    Google Scholar 

  • Wechsler, D., 1989. WPPSI-R: Wechsler Preschool and Primary Scale of Intelligence. Psychological Corporation, New York.

    Google Scholar 

  • Wechsler, D., 1990. Manual for the Wechsler Preschool and Primary Scale of Intelligence-Revised. Psychological Corporation, New York.

    Google Scholar 

  • Wechsler, D., 1995. Manuel: Echelle d’intelligence de Wechsler Pour la Période Préscolaire et Primaire. Forme Réviseé. ECPA, Paris (in French).

    Google Scholar 

  • Wechsler, D., 1999. Wechsler Abbreviated Scale of Intelligence. Psychological Corporation, New York.

    Google Scholar 

  • Williams, J.G., Higgins, J.P., Brayne, C.E., 2006. Systematic review of prevalence studies of autism spectrum disorders. Arch. Dis. Child, 91(1):8–15. [doi:10.1136/adc.2004. 062083]

    PubMed  CAS  Google Scholar 

  • World Health Organization, 2010. Infertility. Available from http://www.who.int/reproductivehealth/topics/infertility/en/index.html [Accessed on Sept. 5, 2010].

    Google Scholar 

  • Zimmer, R., Volkamer, M., 1987. MOT 4–6, Motoriktest fvr 4–6 Jahrige Kinder. Hogrefe, Gottingen (in German).

    Google Scholar 

  • Zink, I., Lejaegere, M., 2003. N-CDI’s Lijsten Voor Communicatieve Ontwikkeling: Korte Vormen. Acco, Leuven/Leusden (in Dutch).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China

    Qi-tao Zhan, Pei-pei Pan, Xiang-rong Xu, Hang-ying Lou, Yi-yun Lou & Fan Jin

Authors
  1. Qi-tao Zhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pei-pei Pan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiang-rong Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hang-ying Lou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yi-yun Lou
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Fan Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fan Jin.

Additional information

Project supported by the National Basic Research Program (973) of China (No. 2012CB944901), the National Natural Science Foundation of China (Nos. 81070532 and 81070541), and the Zhejiang Provincial Natural Science Foundation of China (Nos. Y2100822 and LZ13H040001)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhan, Qt., Pan, Pp., Xu, Xr. et al. An overview of studies on psychological well-being in children born following assisted reproductive technologies. J. Zhejiang Univ. Sci. B 14, 947–960 (2013). https://doi.org/10.1631/jzus.B1300101

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1631/jzus.B1300101

Key words

CLC number

Search

Navigation