Adjunctive benefit of an essential oil–containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly: A six-month study
Section snippets
MATERIALS AND METHODS
We designed a randomized, controlled, observer-blind, parallel-group, six-month clinical trial. The design, execution and analysis of this study were in accordance with ADA Acceptance Program Guidelines on Chemotherapeutic Products for Control of Gingivitis6 and standard operating procedures for Pfizer, which comply with International Conference on Harmonisation Good Clinical Practice guidelines.15 This international standard for pharmaceutical clinical trials ensures credible and accurate data
RESULTS
To ensure against any potential bias, we determined the evaluability of all subjects before breaking any blinded codes. We provide the results from only evaluable subjects’ analyses, since the respective randomized subject analyses essentially were identical. We excluded subjects from evaluation for administrative reasons (that is, dropout or poor compliance), concomitant antibiotic use or other significant medical findings.
We enrolled 246 subjects in the study and randomly assigned them to one
DISCUSSION
The routine of twice daily brushing and once daily interdental cleaning has been the mainstay of oral hygiene recommendations by dental professionals to their patients for decades.1, 19 While long-term studies supporting this routine are relatively few in number,20, 21, 22 this regimen undoubtedly has contributed to better oral health in patients. When we consider contemporary incidence and prevalence of periodontal diseases,2, 3 however, it is apparent that adjunctive methods of plaque and
CONCLUSION
This long-term study demonstrates that the adjunctive use of an EO–containing mouthrinse twice daily provides a meaningful and clinically significant incremental benefit to a recommended regimen of brushing twice daily and flossing once daily. Dental professionals should consider recommending a brush, floss and rinse regimen to their patients when brushing and flossing are not enough to maintain gingival health.
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2018, Journal of DentistryCitation Excerpt :It is also hypothesized that antimicrobial agents present in dentifrices cannot effectively penetrate hard to reach areas in the oral cavity, resulting in biofilm-dwelling bacteria accumulation in the interproximal and interdental spaces. It has been repeatedly demonstrated that the therapeutic benefit of mechanical removal and disruption of accumulating plaque layers is enhanced when used in combination with the antimicrobial action of chemotherapeutic agents present in anti-septic mouthrinses [6–8]. This is because antimicrobial mouthrinses in combination with brushing not only provide additional antimicrobial effects but also penetrate areas in the oral cavity less accessible to mechanical implements and dentifrices.
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Pfizer, Morris Plains, N.J, funded the study described in this article.
- 1
Dr. Sharma is the president and the dental director, BioSci Research Canada, Mississauga, Ontario.
- 2
Ms. Charles is associate director, Clinical Research, Oral Care Research and Development, Pfizer Consumer Healthcare, Pfizer, Morris Plains, N.J.
- 3
Mr. Qaqish is the manager, Clinical Operations, BioSci Research Canada, Mississauga, Ontario.
- 4
Mr. McGuire is an associate director, Statistics, Research and Development, Pfizer Consumer Healthcare, Pfizer, Morris Plains, N.J.
- 5
Mr. Galustians is vice president, Operations, BioSci Research, Canada, Mississauga, Ontario.
- 6
Dr. Kumar is vice president, Oral Care Research and Development, Pfizer Consumer Healthcare, Pfizer, Morris Plains, N.J.