Chest
Volume 116, Supplement 1, July 1999, Pages 9S-15S
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Lung Injury Caused by Mechanical Ventilation

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Types of Ventilator-Induced Lung Injury

Definitive evidence that mechanical ventilation can cause damage to the lungs in humans is difficult to obtain, since it is clearly not possible to perform experiments in which humans are exposed to strategies of ventilation that are thought to be injurious, solely for the purpose of examining the lung injury that it can cause. Thus, a better term that might be used in many human studies is ventilator-associated lung injury. Nevertheless, the weight of evidence obtained from experimental animal

Conclusions

Mechanical ventilation is a mainstay in the therapy of the critically ill patient with respiratory failure. Data that have accumulated largely over the past decade strongly suggest that ventilatory strategies associated with excessive end-inspiratory stretch and/or collapse/recruitment of lung units can cause further injury to the lung and perhaps lead to the development of multiple system organ failure. Insights into mechanisms causing this injury will hopefully lead to the development of

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    Supported in part by Medical Research Council (Canada).

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