Apoptosis – a significant cause of bone cell death in osteonecrosis of the femoral head

J. D. F. Calder; L. Buttery; P. A. Revell; M. Pearse; J. M. Polak

doi:10.1302/0301-620X.86B8.14834

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Apoptosis – a significant cause of bone cell death in osteonecrosis of the femoral head

J. D. F. Calder
L. Buttery
P. A. Revell
M. Pearse
J. M. Polak

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Apoptosis – a significant cause of bone cell death in osteonecrosis of the femoral head

Calder JDF, Buttery L, Revell PA, Pearse M, Polak JM. Apoptosis – a significant cause of bone cell death in osteonecrosis of the femoral head. J Bone Joint Surg Br. 2004;86-B(8):1209-1213. doi:10.1302/0301-620X.86B8.14834

Calder, J. D. F., et al. “Apoptosis – a significant cause of bone cell death in osteonecrosis of the femoral head.” The Journal of Bone & Joint Surgery British Volume, vol. 86-B, no. 8, 2004, pp. 1209-1213., https://doi.org/10.1302/0301-620X.86B8.14834

Calder, J. D. F., Buttery, L., Revell, P. A., Pearse, M., & Polak, J. M. (2004). Apoptosis – a significant cause of bone cell death in osteonecrosis of the femoral head. The Journal of Bone & Joint Surgery British Volume, 86-B(8), 1209-1213. https://doi.org/10.1302/0301-620X.86B8.14834

Calder, J. D. F., Buttery, L., Revell, P. A., Pearse, M. and Polak, J. M. (2004) “Apoptosis – a significant cause of bone cell death in osteonecrosis of the femoral head.” The Journal of Bone & Joint Surgery British Volume, 86-B(8), pp. 1209-1213. Available at: https://doi.org/10.1302/0301-620X.86B8.14834

Calder, J. D. F., L. Buttery, P. A. Revell, M. Pearse, and J. M. Polak. “Apoptosis – a significant cause of bone cell death in osteonecrosis of the femoral head.” The Journal of Bone & Joint Surgery British Volume 86-B, no. 8 (2004): 1209-1213. https://doi.org/10.1302/0301-620X.86B8.14834

Calder JDF, Buttery L, Revell PA, Pearse M, Polak JM. Apoptosis – a significant cause of bone cell death in osteonecrosis of the femoral head. J Bone Joint Surg Br. 2004 Nov 1;86-B(8):1209-1213. https://doi.org/10.1302/0301-620X.86B8.14834

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Abstract

Osteonecrosis of the femoral head usually affects young individuals and is responsible for up to 12% of total hip arthroplasties. The underlying pathophysiology of the death of the bone cells remains uncertain. We have investigated nitric oxide mediated apoptosis as a potential mechanism and found that steroid- and alcohol-induced osteonecrosis is accompanied by widespread apoptosis of osteoblasts and osteocytes. Certain drugs or their metabolites may have a direct cytotoxic effect on cancellous bone of the femoral head leading to apoptosis rather than purely necrosis.

Correspondence should be sent to Mr J. D. F. Calder at Kepper’s Cottage, Swarraton Farm, Alresford, Hampshire SO24 9UD, UK.

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Journal

The Journal of Bone & Joint Surgery British Volume

Volume

86-B No.8 | Pages 1209 - 1213

Section

Research

Published

01 November 2004

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J. D. F. Calder

Consultant Orthopaedic Surgeon, Honorary Senior Lecturer

North Hampshire NHS Trust, Aldermaston Road, Basingstoke, Hampshire RG24 9NA, UK.

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L. Buttery

Tissue Engineering and Regenerative Medicine Imperial College School of Medicine, 369 Fulham Road, London SW10 9NH, UK.

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P. A. Revell

Professor

Department of Histopathology, Royal Free and University College School of Medicine, Pond Street, London NW3 2QG, UK.

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M. Pearse

Consultant Orthopaedic Surgeon and Honorary Senior Lecturer

Department of Orthopaedics, Imperial College School of Medicine, Science and Technology, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK.

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J. M. Polak

Tissue Engineering and Regenerative Medicine Imperial College School of Medicine, 369 Fulham Road, London SW10 9NH, UK.

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