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Improving Symptoms and Quality of Life of Female Cancer Survivors: a Randomized Controlled Study

  • Healthcare Policy and Outcomes
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Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Surgeons, along with the Centers for Disease Control and Prevention, emphasize the importance of managing symptoms and improving the quality of life of cancer survivors. A 2008 meta-analysis of mindfulness-based stress reduction (MBSR) concluded that this technique might improve patients’ adjustment to their disease. However, randomized controlled trials using standardized measures for evaluating MBSR are limited. The primary objective of this study was to evaluate, using valid and reliable measures, the effects of a unique, interactive, 8-week cancer recovery and wellness program on symptoms and quality of life of female cancer survivors.

Methods

Sixty-eight female cancer patients were randomized into either an intervention or waitlisted control group. Patients were evaluated using the Symptoms Checklist (SCL-90-R), the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-30), and the Symptoms of Stress Inventory (SOSI).

Results

Of the participants, 70.6% were breast cancer survivors. Mean age was 57.5 years (treatment group) and 56.4 years (control group). Between-group demographic differences were not significant (P > 0.6). The treatment group improved significantly on the EORTC QLQ-30 (P = 0.005), on six of the eight SOSI subscales (P ≤ 0.049), and on both SCL-90-R subscales (P ≤ 0.023), while the control group did not improve on any of these measures (P > 0.2).

Conclusion

The MBSR-based cancer recovery and wellness intervention improved the symptoms and quality of life of this largely breast cancer survivor population across a variety of cancer symptoms and quality-of-life measures.

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References

  1. National Cancer Institute: Surveillance epidemiology and end results—survival and stage. http://www.seer.cancer.gov/statfacts/html/breast.html#survival (2008). Accessed 20 March 2011.

  2. National Cancer Institute: Estimated US cancer prevalence counts: who are our cancer survivors in the U.S.? http://www.cancercontrol.cancer.gov/ocs/prevalence (2008). Accessed 20 March 2011.

  3. American Cancer Society: Breast cancer facts & figures 2009–2010. http://www.cancer.org/acs/groups/content/@nho/documents/document/f861009final90809pdf.pdf (2010). Accessed 15 January 2011.

  4. Stewart DE, Cheung AM, Duff S, Wong F, McQuestion A, Cheng T, et al. Attributions of cause and recurrence in long-term breast cancer survivors. Psycho-oncology. 2001;10:179–183.

    Google Scholar 

  5. Courneya KS, Freidenreich CM. Framework PEACE: an organizational model for examining physical exercise across the cancer experience. Ann Behav Med. 2001;23:263–272.

    Article  PubMed  CAS  Google Scholar 

  6. Holzner, B, Kemmler G, Kopp M, et al. Quality of life in breast cancer patients—not enough attention for long-term survivors? Psychosomatics. 2001;42:117–123.

    Article  PubMed  CAS  Google Scholar 

  7. Brown JK, Byers T, Doyle C, Coumeya KS, Demark-Wahnefried W, Kushi LH, et al. Nutrition and physical activity during and after cancer treatment: an American cancer society guide for informed choices. CA A Cancer J Clin. 2003;53:268–291 (Information current as of 2 August 2010).

    Google Scholar 

  8. Shen J, Andersen R, Albert PS, Wenger N, Glaspy J, Cole M, Shekelle P. Use of complementary/alternative therapies by women with advance-stage breast cancer. BMC Complement Altern Med. 2002;2:1–7.

    Article  Google Scholar 

  9. Cancer Survivorship. http://www.cdc.gov/cancer/survivorship/ (2009). Accessed 14 Jan 2009.

  10. Kabat-Zinn J, Lipworth L, Burney R. The clinical use of mindfulness meditation for the self-regulation of chronic pain. J Behav Med. 1985;8:163–190.

    Article  PubMed  CAS  Google Scholar 

  11. National Comprehensive Cancer Network: 10 Tips for breast cancer screening and early detection. http://www.nccn.com/cancer-by-type/330-tips-for-breast-cancer-screening.html (2011). Accessed 11 Nov 2010.

  12. American Cancer Society: Breast cancer: early detection. http://www.cancer.org/Cancer/BreastCancer/MoreInformation/BreastCancerEarlyDetection/breast-cancer-early-detection-acs-recs-bse (2010). Accessed 17 April 2011.

  13. National Cancer Institute: Breast cancer screening modalities. http://www.cancer.gov/cancertopics/pdq/screening/breast/healthprofessional/page4 (2008). Accessed 17 April 2011.

  14. Ledesma, D, Kumano H. Mindfulness-based stress reduction and cancer: a meta-analysis. Psycho-Oncology. 2009;18:571–579.

    Article  PubMed  Google Scholar 

  15. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European organization for research and treatment of cancer QLQ-C30: a quality of life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365–376.

    Article  PubMed  CAS  Google Scholar 

  16. Leckie MS, Thompson E. Symptoms of stress inventory. Seattle: University of Washington; 1979.

    Google Scholar 

  17. Carlson LE, Speca M, Patel KD, Goodey E. Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients. Psychosom Med. 2003;65:571–581.

    Article  PubMed  Google Scholar 

  18. Derogatis LR. The brief symptom inventory (BSI). Administration, scoring and procedures manual, 3rd edn. New York: National Computer Systems; 1993.

    Google Scholar 

  19. Kabat-Zinn J. Full catastrophe living: using the wisdom of your body and mind to face stress, pain, and illness. New York: Delta; 1990.

    Google Scholar 

  20. Goldberg N. Writing down the bones. Boston: Shambhala; 2005.

    Google Scholar 

  21. Remen R. Kitchen table wisdom. New York: Riverhead Books; 2006.

    Google Scholar 

  22. Cohen J. Statistical power analysis for the behavioral sciences. New York: Academic; 1988.

    Google Scholar 

  23. Witek-Janusek L, Albuquerque K, Chroniak KR, Chroniak C, Durazo-Arvizu R, Mathews HL. Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer. Brain Behav Immun. 2008;22:969–981.

    Article  PubMed  Google Scholar 

  24. Esplen MJ, Hunter J, Leszcz M, Toner B, Glendon G, Liede A, et al. A Multicenter study of supportive–expressive group therapy for women with BRCA1/BRCA2 mutations. Cancer. 2004;101:2326–2340.

    Article  Google Scholar 

  25. Proulx K. Integrating mindfulness-based stress reduction. Holist Nurs Prac. 2003;17:201–208.

    Google Scholar 

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Acknowledgement

This study was funded in part by the 2010 Oakland University–William Beaumont Hospital Multidisciplinary Research Award. We gratefully acknowledge the study participants for their courage, determination, and openness.

Disclosure and Financial Support

The authors have no conflict of interest or commercial interests in the subject of study.

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Correspondence to Ruth Lerman MD.

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Lerman, R., Jarski, R., Rea, H. et al. Improving Symptoms and Quality of Life of Female Cancer Survivors: a Randomized Controlled Study. Ann Surg Oncol 19, 373–378 (2012). https://doi.org/10.1245/s10434-011-2051-2

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  • DOI: https://doi.org/10.1245/s10434-011-2051-2

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