Open Access
October 2009 Efficient randomized-adaptive designs
Feifang Hu, Li-Xin Zhang, Xuming He
Ann. Statist. 37(5A): 2543-2560 (October 2009). DOI: 10.1214/08-AOS655

Abstract

Response-adaptive randomization has recently attracted a lot of attention in the literature. In this paper, we propose a new and simple family of response-adaptive randomization procedures that attain the Cramer–Rao lower bounds on the allocation variances for any allocation proportions, including optimal allocation proportions. The allocation probability functions of proposed procedures are discontinuous. The existing large sample theory for adaptive designs relies on Taylor expansions of the allocation probability functions, which do not apply to nondifferentiable cases. In the present paper, we study stopping times of stochastic processes to establish the asymptotic efficiency results. Furthermore, we demonstrate our proposal through examples, simulations and a discussion on the relationship with earlier works, including Efron’s biased coin design.

Citation

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Feifang Hu. Li-Xin Zhang. Xuming He. "Efficient randomized-adaptive designs." Ann. Statist. 37 (5A) 2543 - 2560, October 2009. https://doi.org/10.1214/08-AOS655

Information

Published: October 2009
First available in Project Euclid: 15 July 2009

zbMATH: 1171.62043
MathSciNet: MR2543702
Digital Object Identifier: 10.1214/08-AOS655

Subjects:
Primary: 60F15 , 62G10
Secondary: 60F05 , 60F10

Keywords: biased coin design , clinical trial , doubly adaptive biased coin design , power , response-adaptive designs , urn model

Rights: Copyright © 2009 Institute of Mathematical Statistics

Vol.37 • No. 5A • October 2009
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