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Cardiovascular reactivity in cardiovascular disease: “Once more unto the breach”

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Abstract

Discussed here are conceptual and methodologic issues that bear on the role of bebaviorally evoked cardiovascular reactivity in cardiovascular disease. It is argued that recent criticisms concerning the validity of cardiovascular reactivity as a stable dimension of individual differences arise from inadequacies of measurement prevalent in prior literature. With standardization of test stimuli and application of psychometric principles to protocol development, assessments of reactivity are found to be highly reliable and, in turn, to demonstrate the dispositional nature of this construct. Recent studies also document an underlying heterogeneity of hemodynamic reactions to stress, with distinct cardiac and vascular components. Because hemodynamic adjustments show some plasticity under differing task conditions, responses seen in particular contexts reflect influences of both an individual-specific response potential and response-eliciting properties of the stimulus. On the question of disease relevance, it is concluded that cardiovascular reactivity cannot yet be considered as established risk factor for either coronary heart disease or hypertension. However, the preponderance of existing clinical, experimental, and epidemiologic evidence is consistent with such an association and warrants further study in the context of population-based, prospective investigation.

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References

  • Adler, N., & Matthews, K. A. (in press). Health psychology. Annual Review of Psychology.

  • Ahem, D. K., Gorktn, L., Anderson, J. L., Ticrncy, C., Hallstrom, A., Ewarl, C, Capone, R. J., Scbron, E., Kornfeld, D., Herd, J. A., Richardson, D. W., & Follick, M. J. (1990). Biobehavio ral variables and mortality or cardiac arrest in the Cardiac Arrhythia Pilot Study (CAPS). American Journal of Cardiology, 66, 59–62.

    Article  Google Scholar 

  • Ajzen, I. (1988). Altitudes, personality and behavior. Chicago: Dorsey.

    Google Scholar 

  • Ambrosioni, E., Costa, F. V., Mantebugnoli, L., Borghi, C., & Magnani, B. (1981). Intralymphocytic sodium concentration as an index of response to stress and exercise in young subjects with borderline hypertension. Clinical Science, 61, S25-S27.

    Google Scholar 

  • Andren, L., & Hansson, L. (1980). Circulatory effects of stress in essential hypertension. Acta Medica Scandinavica, 646, 69–72.

    Google Scholar 

  • Andren, L., Hansson, L., Eggertsen, R., Hedner, T., & Karlberg, O. (1983). Circulatory effect of noise. Acta Medica Scandinavica, 213, 31–35,

    PubMed  Google Scholar 

  • Blascovich, J., & Katkin, E. S. (Eds.). (1993). Cardiovascular reactivity to psychological stress and disease. Washington, DC; American Psychological Association.

    Google Scholar 

  • Borghi, C., Costa, F, V., Boschi, S., Mussi, A., & Ambrosioni, F. (1986). Predictors of stable hypertension in young borderline subjects: A five-year follow-up study. Journal of Cardiovascular Pharmacology, 8, S138-S141.

    Article  PubMed  Google Scholar 

  • Burton, A. C. (1972). Physiology and biophysics of the circulation. Chicago: Year Book Medical.

    Google Scholar 

  • Cohen, S., Kaplan, J. R., & Manuck, S. B. (in press). Social support and coronary heart disease: Underlying psychologic and biologic mechanisms. In S. A. Shu maker & S. M. Czakowski (Eds.), Social support and cardiovascular disease. New York: Plenum.

  • Corea, L., Benlivoglio, M., & Verdecchia, P. (1983). Echocardiography left ventricular hypertrophy as related to arterial pressure and plasma norepinephrine concentration in arterial hypertension. Hypertension, 5, 837–840.

    PubMed  Google Scholar 

  • Coresh, J., Klag, M. J., Mead, L. A., Liang, K. Y., & Whellon, P. K. (1992). Vascular reactivity in young adults and cardiovascular disease. A prospective study. Circulation, 19, 218–223.

    Google Scholar 

  • Corse, C. D., Manuck, S. B., Cantwell, J. D., Giordani, B., & Matthews, K. A. (1982). Coronary prone behavior pattern and cardiovascular response in persons with and without coronary heart disease. Psychosomatic Medicine, 44, 449–459.

    PubMed  Google Scholar 

  • Costa, P. T., Zondcrman, A. B., Engel, B. T., Baile, W. F., Brimlow, D. L., & Brinker, J. A. (1985). The relation of chest pain symptoms to coronary artery stenosis and neuroticism. Psychosomatic Medicine, 47, 285–293.

    PubMed  Google Scholar 

  • Craven, T. E., Ryu, J. E., Espeland, M. A., Kahl, F. R., McKinney, W. M., Toole, J. F., McMahon, M. R., Thompson, C. J., Heiss, G., & Crouse, J. R., (1990). Evaluation of the associations between carotid artery atherosclerosis and Coronary artery stenosis. Circulation, 82, 1230–1242.

    PubMed  Google Scholar 

  • Crouse, J. R., Toole, J. F., McKinney, W. M., Dignan, M. B., Howard, G., Kahl, F. R., McMahan, M. R., & Harpold, G. H. (1987). Risk factors for extracranial carotid artery atherosclerosis. Stroke, 18, 990–996.

    PubMed  Google Scholar 

  • Dernbroski, T. M., MacDougall, J. M., & Lushenc, R. (1979). Interpersonal interaction and cardiovascular response in Type A subjects and coronary patients. Journal of Human Stress, 5, 28–36.

    Google Scholar 

  • Deveieux, R. B. (1989). Importance of left ventricular mass as a predictor of cardiovascular morbidity in hypertension. American Journal of Hypertension, 2, 650–654.

    Google Scholar 

  • Devcreux, R. B. (1990). Does increased blood pressure cause left ventricular hypertrophy or vice versa? Annate of Internal Medicine, 112, 157–159.

    Google Scholar 

  • Devereux, R. B., Pickering, T. G., Harsbfield, G. A., Kleinert, H. D., Denby, L., Clarck, L., Prcgibon, D., Jason, M., Kleiner, B., Borer, J. S., & Laragh, J. H. (1983). Left ventricular hypertrophy in patients with hypertension: Importance of blood pressure response to regularly recurring stress. Hypertension, 68, 470–476.

    Google Scholar 

  • Uimsdale, J. F., Herd, A., & Hartley, L. H. (1983). Epinephrine mediated increases in plasma cholesterol. Psychosomatic Medicine, 45, 227–232.

    Google Scholar 

  • Rich, R. H., & Jacobscn, E. C. (1967). Vascular reacitivity in medical students followed for 10 years. Journal of Chronic Disease, 20, 583–592.

    Article  Google Scholar 

  • Engel, B. T., & Bickford, A. F. (1961). Response-specificity: Stimulus-response and individualresponse specificity in essential hypertensives. Archives of General Psychiatry, 5, 478–489.

    PubMed  Google Scholar 

  • Epstein, S. (1979). The stability of behavior: I. On predicting most of the people much of the lime. Journal of Personality and Social Psychology, 37, 1097–1126.

    Article  Google Scholar 

  • Epstein, S. (1980). The stability of behavior: H, Implications for psychological research. American Psychologist, 35, 790–807.

    Article  Google Scholar 

  • Follick, M. J., Ahern, D. K., Gorkin, L., Niaura, R. S., Herd, J. A., Ewart, C., Schron, E. B., Kornfeld, D. S., & Capone, R. J. (1990). Relation of psychosocial and stress reactivity variables to ventricular arrhythmias in the Cardiac Arrhythmia Pilot Study (CAPS). American Journal of Cardiology, 66, 63–67.

    Article  PubMed  Google Scholar 

  • Friedman, M. H., O’Brien, V., & Ehrich, L. W. (1975). Calculations of pulsatile flow through a branch. Circulation Research, 36, 277–284.

    PubMed  Google Scholar 

  • Frohlich, E. D., Chobanian, A. V., Devereux, R. B., Dustan, H. P., Dzau, V., Fauad-Tarazi, F., Horan, M. J., Marcus, M., Massic, B., Pfefrer, M. A., Re, R. N., Roccella, E. J., Savage, D., & Sbub, C. (1992). The heart in hypertension. New England Journal of Medicine, 327, 998–1008.

    PubMed  Google Scholar 

  • Gtaconi, S., Palombo, C., Marabolti, C., Genovesi- Ebert, A., Mezzasalma, L., Volterranim, D., & Ghione, S. (1989). Left ventricular mass in borderline hypertension, assessed by echocardiography: Relationships with resting and stress blood pressure. Journal of Nuclear Medicine and Allied Sciences, 33, 26–31.

    Google Scholar 

  • Gordon, D., Guyton, J. R., & Karnovsky, M. J. (1981). Intimal alterations in rat aorta induced by stressful stimuli. Laboratory Investigation, 45, 14–27.

    PubMed  Google Scholar 

  • Grossman, P., & Svebak, S. (1987). Respiratory sinus arrhythmia as an index of parasympathetic cardiac control during active coping. Psychophysiology, 24, 228–235.

    Article  PubMed  Google Scholar 

  • Hammond, I. W., Devereux, R. B., Alderman, M. H., Lutas, E. M., Spitzer, M. C., Crowley, J. S., & Laragh, J. H. (1986). The prevalence and correlates of echocardiography left ventricular hypertrophy among employed patients with uncomplicated hypertension. Journal of the American College of Cardiology, 7, 639–650.

    Article  PubMed  Google Scholar 

  • Harbin, T. J. (1989), The relationship between Type A behavior pattern and physiological responsivity: A quantitative review. Psychophsiology, 26, 110–119.

    Article  Google Scholar 

  • Hardy, J. D., & Smith, T. W. (1988). Cynical hostility and vulnerability to disease: Social support, life stress, and physiological response to conflict. Health Psychology, 7, 447–459.

    Article  PubMed  Google Scholar 

  • Harlan, W. R., Osborne, R. K., & Graybiel, A. (1964). Prognostic value of the cold pressor lest. American Journal of Cardiology, 13, 832–837.

    Article  Google Scholar 

  • Hirsch, K. Z., Maksem, J. A., & Gagen D. (1984). Effects of stress and propranolol on ihe aortic inti’ma of rats. Arteriosclerosis, 4, 526.

    Google Scholar 

  • Houston, B. K. (1992). Personality characteristics, reactivity, and cardiovascular disease. In J. R. Turner, A. Sherwood, & K. C. Light (Eds.), Individual differences in cardiovascular responses to stress (pp. 103–124). New York: Plenum.

    Google Scholar 

  • Jern, S., Uergbrant, A., Bjorntorp, P., & Hansson, L., (1992). Relation of central hemodynamics to obesity and body fat distribution. Hypertension, 19, 520–527.

    PubMed  Google Scholar 

  • Julius, S. (1988). The blood pressure seeking properties of the central nervous system. Journal of Hypertension, 6, 177–185.

    Article  PubMed  Google Scholar 

  • Julius, S., Li, Y., Vrant, D., Krause, L., & Buda, A. J. (1989). Neurogenic pressor episodes fail to cause hypertension, but do induce cardiac hypertrophy. Hypertension, 13, 422–429.

    PubMed  Google Scholar 

  • Julius, S., Weder, A. B., & Hinderlitcr, A. L. (1986). Does behaviorally induced blood pressure variability lead to hypertension? In K. A. Matthews, S. M. Weiss, T. Detre, T. M. Dembroski, B. Falkner, S. B. Manuck, &. R. B. Williams, Jr. (Eds.), Handbook of stress, reactivity and cardiovascular disease (pp. 71–82). New York; Wiley.

    Google Scholar 

  • Kamarck, T. W. (1992). Heceat developments in the study of cardiovascular reactivity: Contributions from psychometric theory and social psychology. Psychophysiotogy, 29, 491–503.

    Article  Google Scholar 

  • Kamaick, T. W., & Jennings, J. R. (1091). Biobchavioral factors in sudden cardiac death. Psychological Bulletin, 109, 42–47.

    Article  Google Scholar 

  • Kamarck, T. W., Jennings, J. R., Debski, T. T., Glickman-Weiss, E., Johnson. P. S., Eddy, M. J., & Manuck, S. B. (1992). Reliable measures of bchaviorally-evokcd cardiovascular reactivity from a PC-based lest battery: Results from student and community samples. Psychophysiotogy, 29, 17–28.

    Article  Google Scholar 

  • Kamarck, T. W., Jennings, J. R., & Manuck, S. B. (in press). Psychometric applications in the assessment of cardiovascular reactivity. Homeostasis in Health and Disease.

  • Kamarck, T. W., Jennings, J. R., Stewart, C. J., & Eddy, M. J. (in press). Reliable responses lo a cardiovascular reactivity protocol: A replication study in a bi-racial female sample. Psychophysiotogy.

  • Kaplan, J, R., Clarkson, T. B., & Manuck, S. B. (1984). Pathogenesis of carotid bifurcation atherosclerosis in cynomolgus monkeys. Stroke, 14, 904–1000.

    Google Scholar 

  • Kaplan, J. R., Manuck, S. B., Adams, M. R., & Ctarkson, T. B. (1987). The effects of beta-adrenergic blocking agents on atherosclerosis and its complications. European Heart Journal, 8, 928–944.

    PubMed  Google Scholar 

  • Kaplan, J. R., Manuck, S. B., Adams, M. R., Weingand, K. W., & Clarkson, T. B. (1987). Inhibition of coronary arthcrosclerosis by propranolol in behaviorally predisposed monkeys fed an atherogenic diet. Circulation, 76, 1364–1372.

    PubMed  Google Scholar 

  • Kaplan, J. R., Manuck, S. B., Adams, M. R., Williams, J. K., Selwyn, A. P., & Clarkson, T. B. (1991). Nonhuman primates as a model for evaluating behavioral influences on atherosclerosis, and cardiac Structure and function. In A. P. Shapiro & A. Baum (Eds.), Perspectives on behavioral medication (pp. 105–129). Hillsdale. NJ: Lawrence Erlbaum Associates, Inc.

    Google Scholar 

  • Kaplan, J. R., Manuck, S. B., Clarkson, T. B., Lusso, F. M., & Taub, D. B. (1982). Social status, environment, and atherosclerosis in cynomolgus monkeys. Arteriosclerosis, 2, 359–368.

    PubMed  Google Scholar 

  • Kaplan, J. R., Manuck, S. B., Clarkson, T. B., &. Prichard, R. W. (1985). Animal models of behavioral influences on athcrogenesis. In E. S. Katkin & S. B. Manuck (Eds.), Advances in behavioral medicine (Vol. 1, pp. 55–110). Greenwich, CT: JAI.

    Google Scholar 

  • Kaplan, J. R., Pcttersson, K., Manuck, S. B., & Olsson, G. (1991). The role of sympathoadrenal medullarv activation in the initiation and progression of atherosclerosis. Circulation. 84(Suppl, VI), 23–32.

    Google Scholar 

  • Kasprowicz A. L., Manuck, S. B., Malkoff, S. B., & Krantz, D. S. (1990). Individual differences in behaviorally evoked cardiovascular response: Temporal stability and hemodynamic patterning. Psychophysiotogy, 27, 605–619.

    Article  Google Scholar 

  • Keys, A., Taylor, H. L., Blackburn, J., Anderson, J.T., & Somonson, E.(1971). Mortality and coronary heart disease among men studied for 23 years. Archives of Internal Medicine, 128, 201–214.

    Article  PubMed  Google Scholar 

  • Krantz, D. S., Hclmers, K. F., Bairey, C. W., Nebel, L. E., Hedges, S. M., & Rozanski, A. (1991). Cardiovascular reactivity and menial stress-induced myocardial ischemia in patients with coronary artery disease. Psychosomatic Medicine, 53, 1–13.

    PubMed  Google Scholar 

  • Krantz, D. S., &. Manuck, S. B. (1984). Acute psychophysiological reactivity and risk of cardiovascular disease: Areview and methodologic critique. Psychological Bulletin, 96, 435–464.

    Article  PubMed  Google Scholar 

  • Krantz, D. S., Sqhaeffer, M. A., Davis, J. E., Dembroski, T. M., MacDougall, J. M., & Shaffer, R. T. (1981). Extent of coronary atherosclerosis, Type A behavior, and cardiovascular response to social interaction. Psychophysiology, 18, 654–664.

    Article  PubMed  Google Scholar 

  • Larkin, K. T., Manuck, S. B., & Kasprowicz, A. L. (1990). The effect of feedback-assisted reduction in heart rate reactivity on videogame performance. Biofeedback and Self-Regulation, 15, 285–303.

    Article  PubMed  Google Scholar 

  • Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Caslelli, W. P. (1990). Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. New England Journal of Medicine, 322, 1561–1566.

    PubMed  Google Scholar 

  • Light, K. C., Dolan, C. A., Davis, M. R., & Sherwood, A. (1992). Cardiovascular responses to an active coping challenge as predictors of blood pressure patterns 10 to 15 years later. Psychosomatic Medicine, 54, 217–230.

    PubMed  Google Scholar 

  • Mahoney, L. T., Schieken, R. M., Clarke, W. R., & Lauer, R. M. (1988). Left ventricular mass and exercise responses predict future blood pressure: The Muscatine Study. Hypertension, 112, 157–159.

    Google Scholar 

  • Malkoff, S. B., Muldoon, M. F., Zeigler, Z. R., & Manuck, S. B. (in press). Blood platelet responsivity to acute mental stress. Psychosomatic Medicine.

  • Malmo, R. B., Shagass, C., & Davis, E. H. (1950). Symptom specificity and bodily reactions during psychiatric interview. Psychosomatic Medicine, 12, 362–376.

    PubMed  Google Scholar 

  • Manuck, S. B. Kamarck, T. W., Kasprowicz, A. S., & Waldsfein, S. R. (1993). Stability and patterning of bchaviorally evoked cardiovascular reactivity. In J. Blascovich & E. S. Kalkin (Eds.), Cardiovascular reactivity to psychological stress and disease (pp. 111–134). Washington, DC: American Psychological Association.

    Chapter  Google Scholar 

  • Manuck, S. B., Kaplan, J. R., Adams, M. R., & Clarkson, T. B. (1989). Behaviorally elicited heart rate reactivity and athrosclcrosis in female cynomolgus monkeys (Macaca fascicularis). Psychosomatic Medicine, 51, 306–318.

    PubMed  Google Scholar 

  • Manuck, S. B., Kaplan, J. R., & Clarkson, T. B. (1983). Behaviorally induced heart rale reactivity and alhrosclerosis in cynomolgus monkeys. Psychosomatic Medicine, 45, 95–108.

    PubMed  Google Scholar 

  • Manuck, S. B., Kaplan, J. R., & Matthews, K. A. (1986). Behavioral antecedents of coronary heart disease and atherosclerosis. Arteriosclerosis, 6, 2–14.

    PubMed  Google Scholar 

  • Manuck, S. B., Kaplan, J. R., Muldoon, M. F., Adams, M. R., & Clarkson, T. B. (1991). The behavioral exacerbation of atherosclerosis and its inhibition by propranolol. In P. McCabe, N. Schneiderman, T. Field, & J. Skylar (Eds.), Stress, coping, and disease (pp. 51–72). Hillsdale, NJ: Lawrence Erlbaum Associates, Inc.

    Google Scholar 

  • Manuck, S. B., Kasprowicz, A. L., Monroe, S. B., Larkin, K. T., & Kaplan, J. R. (1989). Psychophysiologic reactivity as a dimension of individual differences. In N. Schneiderman, S. B. Weiss, & P. Kaufmann (Eds.), Handbook of methods and measurements in cardiovascular behavioral medicine (pp. 365–382). New York: Plenum.

    Google Scholar 

  • Manuck, S. B., Kasprowicz, A. L., & Muldoon, M. F., (1990). Behaviorally-cvoked cardiovascular reactivity and hypertension: Conceptual issues and potential associations. Annals of Behavioral Medicine, 12, 17–29.

    Article  Google Scholar 

  • Manuck, S. B. & Krantz, D. S. (1986). Psychophysiologic reactivity in coronary heart disease and essentia! hypertension. In K. A. Matthews, S. M. Weiss, T. Detre, T. M. Dembroski, B. Falkner, S. B. Manuck, & R. B. Williams, Jr. (Eds.), Handbook of stress, reactivity and cardiovascular disease (pp. 11–34). New York: Wiley.

    Google Scholar 

  • Manuck, S. B., Muldoon, M. F., Kaplan, J. R., Adams, M. R., & Polefrone, J. M. (1989). Coronary artery atherosclerosis and cardiac response to stress in cynomolgus monkeys. In A. W. Sicgman & T. M. Dembroski (Eds.), In search of coronary-prone behavior (pp. 207–227). Hillsdale, NJ: Lawrence Lrlbaum Associates, Inc.

    Google Scholar 

  • Manuck, S. B., Olsson, G., Hjemdahl, P., & Rehnqvisl, N. (1992). Does cardiovascular reacliv. ity to mental stress have prognostic value in postinfarction patients? A pilot study. Psychosomatic Medicine, 54, 102–108.

    PubMed  Google Scholar 

  • Markovilz, J. H., & Matthews, K. A. (1991). Platelets in coronary heart disease: Potential pathophysiologic mechanisms. Psychosomatic Medicine, 53, 643–668.

    Google Scholar 

  • Marks, M. M., Morady, F., & Swan, J. H. C. (1973). Myocardial hypertrophy produced by chronic infusion of subhypcrlcnsive doses of norepinephrine in the dog. Chest, 64, 75.

    Article  Google Scholar 

  • Marsland, A. L., Manuck, S. B., Rabin, B. S., & Cohen, S. (1993). Beta-adrenergic receptor density as a predictor of cardiovascular response to mental stress. Annals of Behavioral Medicine, 15(Suppl.), S669.

    Google Scholar 

  • Matthews, K. A. (1938). Coronary heart disease and Type A behavior: Update on and alternative to the Booth-Kewley and Friedman quantitative review. Psychological Bulletin, 104, 373–380.

    Article  Google Scholar 

  • Matthews, K. A., Weiss, S. M., Detre, T., Dembroski, T. M., Falkner, B., Manuck, S. B., & R. B. Williams, Jr. (Eds.). (1986). Handbook of stress, reactivity and cardiovascular disease. New York: Wiley.

    Google Scholar 

  • Matthews, K. A., Woodall, K. L., & Alien, M. T. (in press). Cardiovascular reactivity to stress predicts future blood pressure status. Hypertension.

  • McCubbin, J. A., Kaplan, J. R., Manuck, S. B., & Adams, M. R. (1993). Opioidergic inhibition of circulatory and endocrine stress responses in oynomolgus monkeys: A preliminary study. Psychosomatic Medicine, 55, 23–28.

    PubMed  Google Scholar 

  • McCubbin, J. A., Surwit, R. S., & Williams, R. B. (1985). Opioid dysfunction and risk for hypertension: Naloxone and blood pressure responses during different types of stress. Hypertension, 7, 808–811.

    PubMed  Google Scholar 

  • Menkes, M. S., Matthews, K. A., Krantz, D. S., Lundbcrg, U., Mead, L. A., Qaqisb, B., Liang, K. Y., Thomas, C. B., & Pearson, T. A. (1989). Cardiovascular reactivity to the cold pressure lest as a predictor of hypertension. Hypertension, 14, 524–530.

    PubMed  Google Scholar 

  • Mills, P. J., & Dimsdale, J. E. (1988). The promise of receptor studies in psychophysiologic research. Psychosomatic Medicine, 50, 555–566.

    PubMed  Google Scholar 

  • Mills, P. J., Dimsdale, J. E., Ziegler, M. G., Berry, C. C., & Bain, R. D. (1990). Beta-adrenergic receptors predict heart rale reactivity to a psychosoical stressor. Psychosomatic Medicine, 52, 621–623.

    PubMed  Google Scholar 

  • Muldoon, M. F., Terrell, D. F., Bunker, C. H., & Manuck, S. B. (1993). Family history studies in hypertension research: Review of the literature. American Journal of Hypertension, 6, 76–88.

    PubMed  Google Scholar 

  • Murphy, J. K., Alpert, B. S., & Walker, S. S. (1992). Ethnicity, pressor reactivity, and children’s blood pressure: Five years of observations. Hypertension, 20, 327–332.

    PubMed  Google Scholar 

  • Parali, G., Tarazzi, S., Ravogli, A., Casadei, R., Omboni, S., & Mancia, G. (1991). Methodological problems in evaluation of cardiovascular effects of stress in humans. Hypertension, 17(Suppl. III), 50–55.

    Google Scholar 

  • Pickering, T. G., & Gerin, W. (1990). Cardiovascular reactivity in the laboratory and the role of behavioral factors in hypertension: A critical review. Annals of Behavioral Medicine, 12, 3–16.

    Article  Google Scholar 

  • Rubens, J., Espeland, M. A., Ryu, J., Harpofd, G., McKinney, W. M., Kahl, F. R., Toole, J. F., & Crouse, J. R. (1988). Individual variation in susceptibility to extracranial carotid atherosclerosis. Arteriosclerosis, 8, 389–397.

    PubMed  Google Scholar 

  • Ryu, J. E., Murros, K., Espeland, M. A., Rubens, J., McKinney, W. M., Toole, J. F., & Crouse, J. R. (1989). Extracranial carotid atherosclerosis in Black and While patients with transient ischemic attacks. Stroke, 20, 1133–1137.

    PubMed  Google Scholar 

  • Saab, P. G., Llabre, M. M., Hurwitz, B. E., Frame, C. A., Reineke, L. J., Fins, A. I., MeCalla, J., Cieply, I. K., & Schneiderman. N. (1992). Myocardial and peripheral vascular responses to behavioral challenges and their stability in Black and White Americans. Psychophysiology, 29, 384–397.

    Article  PubMed  Google Scholar 

  • Saab, P. G., Llabre, M. M., Hurwilz, B. E., Schneiderman, N., Wohlgemuth, W., Durel, L. A., Massie, C., & Nagel, J. (1993). The cold pressor lest: Vascular and myocardial response patterns and their stability. Psychophysiology, 30, 366–373.

    Article  PubMed  Google Scholar 

  • SaJonen, J. T., & Saloncn, R. (1991). Ultrasonographically assessed carotid morphology and the riskof coronory heart Unease. Arteriosclerosis and Thrombosis, 11, 1245–1249.

    Google Scholar 

  • Saloncn, R., Haapanen, A., & Salonen, J. T. (1991). Measurement of intima media thickness of common carotid arteries with high-resolution B-mode ultrasonography: Inter- and intra-observer reliability. Ultrasound in Medicine and Biology, 17, 225–230.

    Article  Google Scholar 

  • Schmieder, R. E., Grube, E., Ruddel, H., Schachinger, H., & Schulte, W. (1990). Relation of hemodynamic reaction during stress to left ventricular hypertrophy in essential hypertension. American Journal of Hypertension, 3, 281–287.

    PubMed  Google Scholar 

  • Schnall, P. L., Pieper, C, Schwartz, J. E., Karasek, R. A, Schlussel, Y., Devereux, R. B., Ganau, A., Alderman, M., Warren, K., & Pickering, T. G. (1990). The relation between “job strain,” workplace diastolic blood pressure, and left ventricular mass index: Results of a case-control study. Journal of the American Medical Association, 263, 1929–1935.

    Article  PubMed  Google Scholar 

  • Schnall, P. L., Schwartz, J. E., Landsbergis, P. A., Warren, K., & Pickering, T. G. (1992). Relation between job strain, alcohol, and ambulatory blood pressure. Hypertension, 19, 488–494.

    PubMed  Google Scholar 

  • Schneiderman, N. (1987). Psychophysiologic factors in albcrogenesis and coronary artery disease. Circulation, 76(Suppl. 6), S41-S47.

    Google Scholar 

  • Shapiro, A. P. (1961). An experimental study of comparative responses of blood pressure lo different noxious stimuli. Journal of Chronic Diseases, 13, 293–311.

    Article  Google Scholar 

  • Sherwood, A., Allen, M. T., Fahrenberg, J., Kelsey, R. M., Lovallo, W. R., & van Doornen, L. J. P. (1990). Methodological guidelines for impedance cardiography. Psychophysiology, 27, 1–23.

    Article  PubMed  Google Scholar 

  • Sherwood, A., Dolan, C. A., & Light, K. C. (1990). Hemodynamics of blood pressure responses during active and passive coping. Psychophysiology, 27, 656–668.

    Article  PubMed  Google Scholar 

  • Smith, T. W., & Allred, K. D. (1989). Blood pressure responses during social interaction inhigh- and low-cynically hostile males. Journal of Behavioral Medicine, 12, 135–143.

    Article  PubMed  Google Scholar 

  • Spencc, J. D., Bass, M., Robinson, H., Cheung, H., Melendez, L. J., Arnold, J. M. O., & Manuck, S. B. (1991). Prospective study of ambulatory monitoring and echocardiography in borderline hypertension. Clinical and Investigative Medicine, 14, 241–250.

    Google Scholar 

  • Strawn, W. B., Bondjers, G., Kaplan, J. R., Manuck, S. B., Schwenke, D. C., Hansson, G. K., Shivcly, C. A., & Clarkson, T. B. (1991). Endothelial dysfunction in response lo psychosocial stress in monkeys. Circulation Research, 68, 1270–1279.

    PubMed  Google Scholar 

  • Suarez, E. C., & Williams, R. B. (1989). Situational determinants of cardiovascular and emotional reactivity in high and low hostile men. Psychosomatic Medicine, 51, 404–418.

    PubMed  Google Scholar 

  • Sutton-Tyrrell, K., Wolfson, S. K., Thompson, T., & Kelsey, S. F. (1992). Measurement variability in duplex scan assessment of carotid atherosclerosis. Stroke, 23, 215–220.

    PubMed  Google Scholar 

  • Trimarco, B., Ricciardelli, B., & DcLuca, N. (1985). Participation of endogenous catecholamines in the regulation of left ventricular mass in progeny of hypertensive parents. Circulation, 72, 38–46.

    PubMed  Google Scholar 

  • Turner, J. R., Sherwood, A., & Light, K. C. (Eds.). (1992). Individual differences in cardiovascular response to stress. New York: Plenum.

    Google Scholar 

  • Waldstcin, S. R., Polcfrone, J. M., Bachcn, E. A., Muldoon, M. F., Kaplan, J. R., & Manuck, S. B. (1993). Relationship of cardiovascular reactivity and anger expression lo serum lipid concentrations in heallhy young men. Journal of Psychosomatic Research, 37, 249–256.

    Article  Google Scholar 

  • Wood, D. L., Sheps, S. G., Elveback, L. R., &. Schirger, A. (1984). Cold pressor test as a predictor of hypertension. Hypertension, 6, 301–306.

    PubMed  Google Scholar 

  • Young, W., Gofman, J. W., Tandy, R., Malamud, N., & Waters, E. S. G. (1960). The quantitation of atherosclerosis: III. The extent or correlation oT degrees of atherosclerosis within and between the coronary and cerebral vascular beds. American Journal of Cardiology, 6, 300–308.

    Article  Google Scholar 

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Authors and Affiliations

  1. Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA

    Stephen B. Manuck

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Preparation of this article was supported by National Institutes of Health Grant HL 40962.

Collaborating investigators for research summarized in Figures 4 to 6 include R. G. Jacob, MD; J. R. Jennings, PhD; T. W. Kamarck, PhD; A. L. Kasprowicz, MS; M. F. Muldoon, MD; J. M. Polefjooe, PhD; V.-E. Smith, MD; D. F. Terrell, PhD; and S. R. Waldstein, PhD.

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Manuck, S.B. Cardiovascular reactivity in cardiovascular disease: “Once more unto the breach”. Int. J. Behav. Med. 1, 4–31 (1994). https://doi.org/10.1207/s15327558ijbm0101_2

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