Skip to main content
SpringerLink
Log in

Failure to maintain adherence to haart in a cohort of French HIV-positive injecting drug users

  • Published:
International Journal of Behavioral Medicine Aims and scope Submit manuscript

Abstract

The study, carriedoutintheFrench MANIF2000 cohortofHIVpositive patients contaminated through injecting drug use, assessed the impact of patients’ sociodemographic and psychological characteristics, behaviors toward drug abuse, and antiretroviral treatment characteristics on the maintenance of adherence to HAART (highly active antiretroviral therapies). A total of 96 patients (30 men and 66 women), who were initially adherent at their first visit after HAART prescription, were considered for analysis. Among these 96 patients, 22 (22.9%) experienced adherence failure defined as a self-reported, non-adherence behavior at any visit before the 18th month of treatment. Logistic regression showed that lack of a stable relationship, active drug injection, and depression were independently associated with adherence failure. Patients’ counseling for facilitating maintenance of adherence to HAART over time should focusonpreventionofdrug use, provisionofsocial support and consider the potential impact of difficulties with treatment on psychological well-being.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Altice, F., & Friedland,J. (1998). The eraofadherenceto antiretroviral therapy.Annals of Internal Medicine, 129, 503–505.

    PubMed  Google Scholar 

  • Avants, S. K., Margolin, A., Warburton, L. A., Hawkins, K. A., & Shi, J. (2001). Predictors of nonadherenceto HIV-related medication regimens during methadone stabilization.American Journal of Addiction, 10, 69–78.

    Article  Google Scholar 

  • Bangsberg, D. R., Hecht, F. M., Charlebois, E. D.,Zolopa, A. R., Holodniy, M., Sheiner, L., et al. (2000). Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population.AIDS, 14, 357–366.

    Article  PubMed  Google Scholar 

  • Bangsberg, D. R., Perry, S., Charlebois, E. D., Clark, R. A., Roberston, M., Zolopa, A. R., et al. (2001). Non-adherence to highly active antiretroviral therapy predicts progression to AIDS.AIDS, 15, 1181–1183.

    Article  PubMed  Google Scholar 

  • Bassetti, S., Battegay, M., Furrer, H., Rickenbach, M., Flepp, M., Kaiser, L., et al. (1999). Why ishighly active antiretroviral therapy (HAART) not prescribed or discontinued? Swiss HIV Cohort Study.Journal of Acquired Immune Deficiency Syndromes, 21, 114–119.

    PubMed  Google Scholar 

  • Calabrese, L. H. (2001). Changing patterns of morbidity and mortality in HIV disease.Cleveland Clinical Journal of Medicine, 68, 105, 9–10, 12.

    Google Scholar 

  • Carr, A., Samaras, K., Burton, S., Law, M., Freund, J., Chisholm, D. J., et al. (1998). A syndrome of peripheral lipodystrophy, hyperlipidaemia, and insulin resistance in patients receiving HIV protease inhibitors.AIDS, 12, F51-F58.

    Article  PubMed  Google Scholar 

  • Carrieri, M., Cailleton, V., Le Moing, V., Spire, B., Dellamonica, P., Bouvet, E., et al. (2001). The dynamic of adherence to highly active antiretroviral therapy (HAART): Results from the French National APROCO cohort.Journal of Acquired Immune Deficiency Syndrome, 28, 232–239.

    Google Scholar 

  • Catz, S. L., Kelly, J. A., Bogart, L. M., Benotsch, E. G., & McAuliffe, T. L. (2000). Patterns, correlates, and barriers to medication adherence among persons prescribed new treatments for HIV disease.Health Psychology, 19, 124–133.

    Article  PubMed  Google Scholar 

  • Chesney, M. A., Ickovics, J., Hecht, F. M., Sikipa, G.,; & Rabkin, J. (1999). Adherence: A necessity for successful HIV combination therapy.AIDS, 13, S271-S278.

    Article  PubMed  Google Scholar 

  • Chesney, M. A., Ickovics, J. R., Chambers, D. B., Gifford, A. L., Neidig, J., Zwicki, B., et al. (2000). Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG adherence instruments. Patient Care Committee and Adherence Working Group of the Outcomes Committeeofthe Adult AIDS ClinicalTrials Group (AACTG).AIDS Care, 12, 255–266.

    Article  PubMed  Google Scholar 

  • Chesney, M. A., Morin, M., & Sherr, L. (2000). Adherence to HIV combination therapy.Social Science & Medicine, 50, 1599–1605.

    Article  Google Scholar 

  • Clumeck, N., Goebel, F., Rozenbaum, W., Gerstoft, J., Staszewski, S., Montaner, J., et al. (2001). Simplification with abacavir-based triple nucleoside therapy versus continued protease inhibitor-based highly active antiretroviral therapy in HIV-1-infected patients with undetectable plasma HIV-1 RNA.AIDS, 15, 1517–1526.

    Article  PubMed  Google Scholar 

  • Cook, R. L., Sereika, S. M., Hunt, S. C., Woodward, W. C., Erlen, J. A., & Conigliaro, J. (2001). Problem drinking and medication adherence among persons with HIV infection.Journal of General Internal Medicine, 16, 83–88.

    Article  PubMed  Google Scholar 

  • Duong, M., Piroth, L., Peytavin, G., Forte, F., Kohli, E., Graypin, M., et al. (2001). Value of patient self-report and plasma human immunodeficiency virus protease inhibitor level as markers of adherence to antiretroviral therapy: relationship to virologic response.Clinical Infectious Diseases, 33, 386–392.

    Article  PubMed  Google Scholar 

  • Duran, S., Saves, M., Spire, B., Cailleton, V., Sobel, A., Carrieri, P., et al. (2001). Failure to maintain long-term adherence to highly active antiretroviral therapy: The role of lipodystrophy.AIDS, 15, 2441–2444.

    Article  PubMed  Google Scholar 

  • Duran, S., Solas, C., Spire, B., Carrieri, M. P., Fuzibet, J. G., Costagliola, D., et al. (2001). “Do HIV-infected injecting drug users over-report adherence to highly active antiretroviral therapy?” A comparison between patients’ self-reports and serum protease inhibitor concentrations in the French Manif 2000 cohort study.AIDS, 15, 1075–1077.

    Article  PubMed  Google Scholar 

  • Duran, S., Spire, B., Raffi, F., Walter, V., Bouhour, D., Taurnot, J., et al. (2001). Self-reported symptoms after initiationof a protease inhibitorin HIV-infected patients and their impact on adherence to HAART.HIV Clinical Trials, 2, 38–45.

    Article  PubMed  Google Scholar 

  • Eron, J. J., Yetzer, E. S., Ruane, P. J., Becker, S., Sawyer, G. A., Fisher, R. L., et al. (2000). Efficacy, safety, and adherence with a twice-daily combination lamivudine/zidovudine tablet formulation, plus a protease inhibitor, in HIV infection.AIDS, 14, 671–681.

    Article  PubMed  Google Scholar 

  • Fuhrer, R., & Rouillon, F. (1989). Laversion française de ľéchelle CES-D [Description and translation of the autoevaluation scale].Psychiatrie et Psychobiologie, 4, 163–166.

    Google Scholar 

  • Gifford, A. L., Bormann, J. E., Shively, M. J., Wright, B. C., Richman, D. D., & Bozzette, S. A. (2000). Predictors of self-reported adherence and plasma HIV concentrations in patients on multidrug antiretroviral regimens.Journal of Acquired Immune Deficiency Syndromes, 23, 386–395.

    PubMed  Google Scholar 

  • Gordillo, V., del Amo, J., Soriano, V., & Gonzalez-Lahoz, J. (1999). Sociodemographic and psychological variables influencing adherence to antiretroviral therapy.AIDS, 13, 1763–1769.

    Article  PubMed  Google Scholar 

  • Graham, N. M. (1998). Studies of antiretroviral therapy in the Multicenter AIDS Cohort Study.Journal of Acquired Immune Deficiency Syndrome &Human Retrovirology, 17, S9-S12.

    Google Scholar 

  • Haubrich, R. H., Little, S. J., Currier, J. S., Forthal, D. N., Kemper, C. A., Beall, G. N., et al. (1999). The value of patient-reported adherence to antiretroviral therapy in predicting virologic and immunologic response. California Collaborative Treatment Group.AIDS, 13, 1099–107

    Article  PubMed  Google Scholar 

  • Hogg, R. S., Heath, K. V., Yip, B., Craib, K. J., O’Shaughnessy, M. V., Schechter, M. T., et al. (1998). Improved survival among HIV-infected individuals following initiation of antiretroviral therapy.The Journal of the American Medical Association, 279, 450–454.

    Article  Google Scholar 

  • House, J. (1981).Work, stress, and social support. Reading, MA: Addison-Wesley.

    Google Scholar 

  • Hung, C. C., Chen, M. Y., Hsieh, S. M., Sheng, W. H., & Chang, S. C. (2000). Clinical spectrum, morbidity, and mortality of acquired immunodeficiency syndrome in Taiwan: A 5-year prospective study.Journal of Acquired Immune Deficiency Syndromes, 24, 378–385.

    PubMed  Google Scholar 

  • Johnston-Roberts, K., & Mann, T. (2000). Barriers to antiretroviral medication adherence in HIV-infected women.AIDS Care, 12, 377–386.

    Article  Google Scholar 

  • Kastrissios, H., Suarez, J., Katzenstein, D., Girard, P., Sheiner, L., & Blaschke, T. (1998). Characterizing patterns of drug-taking behavior with a multiple drug regimen in an AIDS clinical trial.AIDS, 12, 2295–2303.

    Article  PubMed  Google Scholar 

  • Lerner, B., Gulick, R., & Dubler, N. (1998). Rethinking non-adherence: Historical perspectives on triple-drug therapy for HIV disease.Annals of Internal Medicine, 129, 573–578.

    PubMed  Google Scholar 

  • Levy, R. L. (1983). Social support and compliance: A selective review and critique of treatment integrity and outcome measurement.Social Science & Medicine, 17, 1329–1338.

    Article  Google Scholar 

  • Liang, K.,; & Zeger, S. (1986). Longitudinal data analysis using generalized linear models.Biometrika, 73, 13–22.

    Article  Google Scholar 

  • Lucas,G. M., Cheever, L.W., Chaisson, R. E., & Moore, R. D. (2001). Detrimental effects of continued illicit drug use on the treatment of HIV-1 infection.Journal of Acquired Immune Deficiency Syndromes, 27, 251–259.

    PubMed  Google Scholar 

  • Mannerheimer, S., Friedland, G., Matts, J., Chen, L., Child, C., McArthur, M., et al. (2000).Self-reported antiretroviral adherence correlates with HIV viral load and declines over time. Presented at XIIIth International AIDS conference, Durban, 2-14, July 2000. Abstract TUORB421.

  • Max, B.,; & Sherer, R. (2000). Management of the adverse effects of antiretroviral therapy and medication adherence.Clinical Infectious Diseases, 30(Suppl 2), S96-S116.

    Article  PubMed  Google Scholar 

  • Miller, L. G., & Hays, R. D. (2000). Adherence to combination antiretroviral therapy: Synthesis of the literature and clinical implications.The AIDS Reader, 10, 177–185.

    PubMed  Google Scholar 

  • Moatti, J., Spire, B.,; & Duran, S. (2000). A review of socio-behavioural studies on adherence to antiretroviral treatments: Beyond biomedical models?Revue ďEpidemiologie et de Santé Publique, 48, 182–197.

    Google Scholar 

  • Moatti, J. P., Carrieri, M. P., Spire, B., Gastaut, J. A., Cassuto, J. P., & Moreau, J. (2000). Adherence to HAART in French HIV-infected injecting drug users: The contribution of buprenorphine drug maintenance treatment. The Manif 2000 study group.AIDS, 14, 151–155.

    Article  PubMed  Google Scholar 

  • Molina, J. M., Ferchal, F., Rancinan, C., Raffi, F., Rozenbaum, W., Sereni, D., et al. (2000). Once-daily combination therapy with emtricitabine, didanosine, and efavirenz in human immunodeficiency virus-infected patients.Journal of Infectious Diseases, 182, 599–602.

    Article  PubMed  Google Scholar 

  • Morse, E., Simon, P., Coburg, M., Hyssop, N., Greenspan, D.,; & Balson, P. (1991). Determinants of subject compliance within an experimental anti-HIV drug protocol.Social Science & Medicine, 32, 1161–1167.

    Article  Google Scholar 

  • Murri, R., Ammassari, A., Gallicano, K., De Luca, A., Cingolani, A., Jacobson, D., et al. (2000). Patient-reported nonadherence to HAART is related to protease inhibitor levels.Journal of Acquired Immune Deficiency Syndromes, 24, 123–128.

    PubMed  Google Scholar 

  • Ostrop, N. J., Hallett, K. A., Gill, M. J. (2000). Long-term patient adherence to antiretroviral therapy.Annals of Pharmacotherapy, 34, 703–709.

    Article  PubMed  Google Scholar 

  • Paterson,D. L., Swindells, S., Mohr, J., Brester, M., Vergis, E.N., Squier, C., et al. (2000). Adherence to protease inhibitor therapy and outcomesinpatients with HIV infection.Annals of Internal Medicine, 133, 21–30.

    PubMed  Google Scholar 

  • Pierret, J. (2000). Everyday life with AIDS/HIV: Surveysin the social sciences.Social Science & Medicine, 50, 1589–1598.

    Article  Google Scholar 

  • Pilisuk, M. (1978). Kinship, social networks, social support and health.Social Science & Medicine, 12, 273–280.

    Google Scholar 

  • Roca, B., Gomez, C. J., & Arnedo, A. (1999). Stavudine, lamivudine and indinavir in drug abusing and non-drug abusing HIV-infected patients: Adherence, side effects and efficacy.Journal of Infection, 39, 141–145.

    Article  PubMed  Google Scholar 

  • Schneiderman, N., Antoni, M. H., Saab, P. G., & Ironson, G. (2001). Health psychology: Psychosocial and biobehavioral aspects of chronic disease management.Annual Review of Psychology, 52, 555–580.

    Article  PubMed  Google Scholar 

  • Sherer, R. (1998). Adherence and antiretroviral therapyininjection drug users.The Journal of the American Medical Association, 280, 567–568.

    Article  Google Scholar 

  • Singh, N., Squier, C., Sivek, C., Wagener, M., Nguyen, M.,; & Yu, V. (1996). Determinants of compliance with antiretroviral therapy in patients with human immunodeficiency virus: Prospective assessment with implications for enhancing compliance.AIDS Care, 8, 261–269.

    Article  PubMed  Google Scholar 

  • Smith, M., Rapkin, B., Morrison, A.,; & Kammerman, S. (1997). Zidovudine adherence in persons with AIDS: The relationship of patients beliefs about medication to self-termination of therapy.Journal of General Internal Medicine, 12, 216–223.

    PubMed  Google Scholar 

  • Spire, B., Duran, S., Souville, M., Leport, C., Raffi, F.,; & Moatti, J. (2002). Adherence to highly active antiretroviral therapy (HAART) inHIV-infected patients: From a predictive toa dynamic approach.Social Science & Medicine, 54, 1481–1496.

    Article  Google Scholar 

  • Stein, M. D., Rich, J. D., Maksad, J., Chen, M. H., Hu, P., Sobota, M., et al. (2000). Adherence to antiretroviral therapy among HIV-infected methadone patients: effect of ongoing illicit drug use.American Journal of Drug & Alcohol Abuse, 26, 195–205.

    Article  Google Scholar 

  • Stone,V. E. (2001). Strategies for optimizing adherence tohighly active antiretroviral therapy: Lessons from research and clinical practice.Clinical Infectious Diseases, 33, 865–872.

    Article  PubMed  Google Scholar 

  • Swindells, S., Mohr, J., Justis, J.C., Berman, S., Squier, C., Wagener, M. M., etal. (1999). Qualityoflife in patients with human immunodeficiency virus infection: Impactofsocial support, coping style and hopelessness.International Journal of STDs & AIDS, 10, 383–391.

    Article  Google Scholar 

  • Wagner, G., & Rabkin, J. (2000). Measuring medication adherence: Are missed doses reported more accurately than perfect adherence.AIDS Care, 12, 405–408.

    Article  PubMed  Google Scholar 

  • Wallston, B., Alagna, S., De Vellis, B., & De Vellis, M. (1983). Social support and physical health.Health Psychology, 2, 367–391.

    Article  Google Scholar 

  • Wasserman, S.,; & Faust, K. (1994).Social network analysis. Cambridge, UK: Cambridge University Press.

    Google Scholar 

  • Wendel, C. S., Mohler, M. J., Kroesen, K., Ampel, N. M., Gifford, A. L., & Coons, S. J. (2001). Barriers to use of electronic adherence monitoring in an HIV clinic.Annals of Pharmacotherapy, 35, 1010–1015.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. INSERM Research Unit 379, 23 Rue Stanislas Torrents, 13006, Marseille, France

    M. P. Carrieri, B. Spire, A. Loundou & J. P. Moatti

  2. Center for AIDS prevention studies, University of California, San Francisco

    M. A. Chesney

  3. CHU Créteil, France

    A. Sobel

  4. Department of Hematology, H. Duffaut Hospital, Avignon, France

    G. Lepeu

Authors
  1. M. P. Carrieri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. A. Chesney
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Spire
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Loundou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Sobel
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. Lepeu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. P. Moatti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. P. Moatti.

Additional information

Special thanks must be addressed to all nurses who were involved in this work and to all patients living with HIV that took part in this study.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Carrieri, M.P., Chesney, M.A., Spire, B. et al. Failure to maintain adherence to haart in a cohort of French HIV-positive injecting drug users. Int. J. Behav. Med. 10, 1–14 (2003). https://doi.org/10.1207/S15327558IJBM1001_01

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1207/S15327558IJBM1001_01

Key words

Search

Navigation