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Prevalence of chronic disabling fatigue in children and adolescents

Published online by Cambridge University Press:  02 January 2018

Anne Farmer*
Affiliation:
MRC Social, Genetic, Developmental Psychiatric Research Centre, Institute of Psychiatry, London
Tom Fowler
Affiliation:
MRC Social, Genetic, Developmental Psychiatric Research Centre, Institute of Psychiatry, London
Jane Scourfield
Affiliation:
MRC Social, Genetic, Developmental Psychiatric Research Centre, Institute of Psychiatry, London
Anita Thapar
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
*
Professor Anne Farmer, MRC Social, Genetic, Developmental Psychiatric Research Centre, Institute of Psychiatry, De Crespigny Park, Camberwell, London SE5 8AF, UK. Tel: +44 (0) 207 848 0940; fax: +44 (0) 207 848 0856; e-mail: spjuaef@iop.kcl.ac.uk
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Abstract

Background

The epidemiology of chronic fatiguing illnesses in young people is poorly understood.

Aims

To estimate the lifetime prevalence of different definitions of chronic fatigue in 8-to 17-year-olds.

Method

Participants came from two population-based twin series. Parents completed self-report questionnaires that enquired whether either child had ever experienced more than a few days of disabling fatigue. Telephone interviews were undertaken for individuals who had experienced such an episode.

Results

Questionnaires were returned by 1468 families (65% response rate) and telephone interviews were undertaken regarding 99 of the 129 subjects (77%) who had experienced fatigue. The lifetime prevalence estimates ranged from 2.34% (95% CI 1.75–2.94) for disabling fatigue lasting 3 months to 1.29% (95% CI 0.87–1.71) for a disorder resembling adult operationally defined chronic fatigue syndrome.

Conclusions

From the age of 11 years, young people have similar rates and types of chronic fatiguing illnesses to adults.

Type
Papers
Copyright
Copyright © 2004 The Royal College of Psychiatrists 

Chronic fatiguing disorders occurring in adolescence can cause considerable morbidity and severe impairment of educational attainment and social development (Reference Dowsett and ColbyDowsett & Colby, 1997). In a workshop report, Marshall (Reference Marshall1999) noted the lack of epidemiological studies in this age group and pointed to the need for population-based samples that avoid referral and treatment-seeking biases. Other recent reviews highlight the lack of research in this age group compared with adults (Reference Garralda and RangelGarralda & Rangel, 2001). In particular, there is little agreement about the prevalence of disabling fatigue in young people or whether the narrow definitions of chronic fatigue syndrome (CFS) devised to standardise diagnosis in adult populations (Reference Fukuda, Straus and HickieFukuda et al, 1994) are relevant to these younger age groups (Reference MarshallMarshall, 1999). In the current study we have used two general population-based twin series to derive lifetime prevalence estimates of different definitions of chronic fatigue in 8- to 17-year-olds.

METHOD

Participants

The participants were identified from two population-based twin registers based in South Wales and Greater Manchester. These registers have been amalgamated recently to form the ‘Cardiff Study of All Wales and Northeast England Twins’ twin register (CASTANET). Both registers were set up from birth registers and were originally created from community child health databases. Initially, twin pairs were excluded if one or both twins had severe learning disability, severe physical handicap or if one of the twins had died. Previous studies have shown that the registers are representative of the local population (Reference Scourfield, Martin and LewisScourfield et al, 1999; Reference Thapar, Harrington and RossThapar et al, 2000).

The combined registers consisted of 3051 pairs of twins aged 8–17 years. The general practitioners of all the twins were first contacted to check for any contra-indications to contact by the study team, which led to 34 families not being approached. A further 748 families could not be located at the address listed on the register and further efforts to verify the current address held by a British Telecom database or the electoral register proved unsuccessful. Consequently, the final sample consisted of 2269 twin pairs, of whom 29.8% came from South Wales and 70.2% from Manchester.

Measures

The parents were sent questionnaires relating to each child separately, to complete and return by post. Three reminder letters and a further set of questionnaires were sent to non-responders 4 months after the first mailing.

The questionnaires enquired whether the child had ever experienced a period of tiredness lasting at least several days that had caused interference with activities such as being able to go to school or see friends or family. If they answered ‘yes’ to this question, they were asked to indicate the duration of the disabling fatigue on a five-point scale, ranging from ‘a few days’ to ‘more than 6 months’. Parents were also asked to give written consent to further contact by telephone.

Those who agreed to further contact and where one or both children had experienced more than a few days of fatigue were interviewed by telephone. For those over the age of 11 years, both the main carer and the young person were interviewed. For younger participants, only the parent/main carer was interviewed. In this study we report on the results of the parents’ interviews.

The interview consisted of two parts. The first part obtained further details about the period(s) of fatigue, including the type and degree of impairment in functioning as well as information to determine whether the young person had experienced a similar symptom profile, duration and impairment to the Centers for Disease Control operational criteria for CFS in adults (Reference Fukuda, Straus and HickieFukuda et al, 1994). The second part of the interview consisted of the depression section of the Child and Adolescent Psychiatric Assessment (Reference Angold and CostelloAngold & Costello, 1995).

Information was sought about the duration of the fatigue and whether it had been continuous or episodic. The nature and degree of impairment associated with the fatigue was assessed by enquiring about whether the twin needed to rest for at least 1 hour daily, whether there was interference with school attendance, and how the tiredness interfered with the subject's usual activities and family and peer relationships. With regard to school attendance, the parent was asked whether the twin needed to take time off from school and whether the amount of time off from school meant that the twin had to repeat a school year, catch up in the school holidays, have a home tutor, have work sent home by teachers or have a reduced timetable. Parents were also asked about the number of visits to general practitioners and/or hospital specialists made regarding the fatigue. The interviewer also recorded verbatim the diagnoses that the parent reported had been made by the general practitioner and/or hospital specialist. The physician diagnoses were reviewed by an independent clinician who determined those cases where the diagnosis could entirely explain the chronic fatigue in the twin. These cases were then excluded from further analysis. In addition, the parent was also asked what he or she thought was the cause of the fatigue. These responses were also recorded verbatim.

To assess whether the young person's fatigue resembled that found in adults and fulfilled the adult Centers for Disease Control criteria for CFS (Reference Fukuda, Straus and HickieFukuda et al, 1994), enquiry was made about symptoms that sometimes occur with fatigue. These were lack of energy, need for rest, unrefreshing sleep, muscle pain, eye strain, poor memory and concentration, ‘slips’ of the tongue, difficulty in initiating activities, fatiguability, headaches, multiple joint pains, tender lymph nodes, feeling weak, sore throats, difficulty thinking or post-exertion malaise associated with the period of fatigue. These items were rated as ‘less than usual’, ‘same as usual’, ‘more than usual’ or ‘a lot more than usual’ for the episode of chronic fatigue.

The second part of the telephone interview consisted of the depression section of the Child and Adolescent Psychiatric Assessment (Reference Angold and CostelloAngold & Costello, 1995), a semi-structured investigator-based research diagnostic interview. The responses to this were used to apply the DSM–IV (American Psychiatric Association, 1994) operational criteria for major depression for the episode of fatigue.

Analyses

The population-based twin pairs can be considered as independently sampled, but each pair contributes two sets of observations that cannot be classed as independent (Reference Bland and KerryBland & Kerry, 1997). Consequently, the survey analysis procedures of Stata Release 6 for PC were used to adjust the variances of the analyses, which were used in versions of independent t-tests and χ2 tests.

Because not all families where there were positive replies to the screening fatigue questions wished to be interviewed, a mid-range estimate of prevalence was calculated that assumed that the same proportion of children fulfilled the different definitions of chronic fatigue in those from families who did not agree to participate as among those who did.

RESULTS

Response rates

Parents from 1468 families returned questionnaires, which is a response rate of 65%. There were no significant socio-demographic differences between the responding and non-responding families (Reference Rice, Harold and ThaparRice et al, 2002).

One hundred and twenty-nine young people (4.4%) were identified by the screening questionnaires as having experienced more than a few days of disabling fatigue, and telephone interviews were undertaken for 99 (77%). Of those not interviewed, 15 had indicated that they did not wish to participate and a further 15 failed to respond to written requests for telephone contact. Following the interview, three young people who had diagnoses of cerebral palsy, nephrotic syndrome and thalassaemia were also excluded following independent paediatric advice that these disorders could entirely explain the fatigue. Thus, the following results are based on 96 young people (see Fig. 1).

Fig. 1 Flow chart of subject inclusions and exclusions in the study (Qs, questionnaires; GP. general practitioner).

Age at interview, gender and location

For 12 families both twins were reported as having experienced disabling fatigue, whereas for 72 families only one twin was reported as having experienced disabling fatigue. Thirty-one (32%) of the twins came from South Wales whereas 65 (68%) came from Greater Manchester. Two-thirds (64) of the fatigued twins were female and one-third (32) were male. The mean age at interview was 14 years 8 months (range: 9 years 5 months to 18 years 5 months).

Characteristics of fatigue

The mean age of onset of fatigue in the 32 boys was 11 years 1 month (s.e.=7.93 months) and for the 64 girls it was 11 years 3 months (s.e.=6.23 months). There were no significant gender differences for age at onset.

The mean duration of fatigue in the 32 boys was 9.18 months (s.e.=5.15) and for the 64 girls it was 13.84 months (s.e.=3.51). There were no significant gender differences for duration of fatigue.

Other symptoms associated with prolonged fatigue

Table 1 shows that the most common associated symptoms were lacking energy, needing to rest, multiple joint pain and unrefreshing sleep. The Centers for Disease Control criteria for CFS in adults (Reference Fukuda, Straus and HickieFukuda et al, 1994) require the presence of at least four out of eight minor symptoms concomitant with the period of fatigue (these eight symptoms are indicated by asterisks in Table 1). A total of 86% of boys and 77% of girls had at least four concomitant symptoms.

Table 1 Frequencies of symptoms associated with prolonged fatigue in boys and girls

Symptom Frequency (%) in boys Frequency (%) in girls
Lack energy 94 86
Rest more 85 88
Multiple joint pain* 85 78
Unrefreshing sleep* 85 73
Post-exertional malaise* 76 69
Difficulty starting things 76 69
Poor concentration* 76 64
Headaches* 64 65
Feel weak 52 61
Fatiguability 45 42
Muscle pain* 39 39
Tender lymph nodes* 39 52
Difficulty thinking 33 45
Sore throats* 27 45
Slips of the tongue 24 22
Poor memory 18 23
Eyestrain 18 34

Educational and social impairment

A total of 14 boys (44%) and 34 girls (53%) had to have time off from school because of the fatigue and for 9 boys (28%) and 24 girls (38%) this interference with their education was more severe, requiring extra work in the holidays, work sent home by teachers, a home tutor or a reduced timetable. Boys missed a mean of 9.50 days (s.e.=2.22) and girls missed a mean of 14.62 days (s.e.=1.97) per term. Parents of all 96 subjects reported that chronic fatigue had caused impaired relationships with family and friends and reduced participation in leisure activities.

Visits to doctors

General practitioners were consulted about the fatigue for 22 boys (67%) and 44 girls (67%). For 12 (36%) boys and 24 (36%) girls a hospital specialist opinion was also sought. For the boys, the mean number of visits to the general practitioner was 2 (s.e.=0.26) and for girls it was 4.35 (s.e.=0.75). Girls had significantly more visits to their general practitioners compared with boys (t=-2.96, d.f.=64, P=0.005). In 22 cases general practitioners considered that the tiredness was due to some type of infection, including glandular fever (five cases), but in 21 cases they failed to give an explanation for the fatigue according to the interviewed parent. Psychological causes, age, hormones or puberty were given as causes of the fatigue in nine subjects whereas single causes were given for the remainder. Hospital specialists were more likely to have given a diagnosis for the cause of the fatigue and there was uncertainty only in five cases. Psychological or psychiatric causes were given in five cases and specific infections in four. The general practitioners and specialists were reported to have carried out 42 blood tests, of which eight had positive findings (four indicated an infection and four indicated anaemia). Only in one case was a diagnosis of CFS made by a hospital specialist (a full table of the diagnoses given and tests undertaken by general practitioners and hospital specialists can be obtained from the authors on request). The commonest parental attribution for fatigue in their twin was a psychological cause (28% of fatigued twins) whereas a further 20% of parents thought that their twin's fatigue was due to an infection. Chronic fatigue syndrome or myalgic encephalomyelitis was not attributed as a cause by any parent (a full table of all the causes cited by parents for fatigue in the twins can be obtained from the authors on request).

Depression and chronic fatigue

Twelve boys (38%) and 25 girls (39%) fulfilled the DSM–IV operational definitions for mild, moderate or severe depression during the episode of fatigue. There were no gender differences for concomitant depression. Table 2 shows that the percentage of subjects with co-occurring depression rises as the duration and severity of the fatigue increases.

Table 2 Number of fatigued boys and girls, mean age at onset and % with comorbid depression for five categories: any duration, at least 1 month, 3 months or more, 3 months and at least four minor symptoms and 6 months or more and at least four minor symptoms

Duration of fatigue (±4 minor symptoms) No. of boys No. of girls Age at onset in months in boys (s.e.) Age at onset in months in girls (s.e.) % Boys with depression1 % Girls with depression1
More than a few days 32 64 133.50 (7.93) 135.41 (6.23) 38% 39%
At least 1 month 19 50 143.84 (10.71) 136.42 (6.99) 42% 46%
3 months 17 44 144.82 (11.70) 136.75 (7.72) 41% 48%
3 months (±4) 14 36 149.21 (8.75) 134.78 (9.09) 36% 53%
6 months (±4) 9 26 148.22 (10.99) 140.38 (11.22) 56% 50%

Numbers of subjects fulfilling different definitions of chronic fatigue and CFS

Table 2 shows that of the 32 boys and 64 girls with more than a few days of chronic fatigue, for 19 boys and 50 girls this lasted for at least 1 month. For 17 boys (53%) and 44 girls (67%) the chronic fatigue had lasted at least 3 months, of whom 14 boys (44%) and 36 girls (55%) had also had at least four concomitant symptoms. Nine boys (28%) and 26 girls (41%) experienced fatigue lasting 6 months with at least four concomitant symptoms. There were no gender differences for these different severities of fatigue. Table 2 also shows that the mean ages of onset for these different durations of fatigue ranged from 11.13 years to 12.43 years, and that between one-third and a half of the subjects also fulfilled DSM–IV criteria for depression during the period of chronic fatigue.

Prevalence of different definitions of chronic fatigue

The estimated prevalence of fatiguing illness lasting 3 months or more was 2.34% (95% CI 1.75–2.94) whereas the prevalence of fatigue lasting 3 months accompanied by at least four minor symptoms from the Centers for Disease Control criteria for CFS was 1.90% (95% CI 1.40–2.40). Lastly, the prevalence of 6 months or more of fatigue with at least four minor symptoms was 1.29% (95% CI 0.87–1.71).

DISCUSSION

The present study has been undertaken in twin samples that have been shown to be representative of the general populations of South Wales and Greater Manchester. Because there is no evidence that twins are either more or less susceptible to chronic fatigue or CFS than singletons, it is reasonable to use the CASTANET twin sample to derive population prevalence estimates (Reference Thapar, Harrington and RossThapar et al, 2000; Reference Rice, Harold and ThaparRice et al, 2002).

Frequency, duration and age of onset of chronic disabling fatigue in young people

The results show that disabling fatigue in young people is not rare and that 4.4% of the parents who responded to a questionnaire survey reported the symptom lasting for more than a few days in one or both of their children. However, this is less than half the rate in adults where estimates for the rates of ‘persistent fatigue’ complaints to primary care physicians range from 11% to 27% (Reference Wessely, Chalder and HirschWessely et al, 1997; Reference Skapinakis, Lewis and MeltzerSkapinakis et al, 2000; Reference Sharpe and WilksSharpe & Wilks, 2002). The study showed that the mean duration of chronic fatigue (9.57 months for boys and 13.49 months for girls) is similar to that reported in studies of CFS in paediatric clinic samples. For example, Carter et al (Reference Carter, Edwards and Kronenberger1995) report a mean duration of 11 months in 20 individuals whose mean age was 13 years, whereas Feder et al (Reference Feder, Dworkin and Orkin1994) report a mean duration of 7 months in 48 young people whose mean age was 15 years. However, the individuals in the present study were younger than these specialist clinic referrals, with the mean age at onset for both genders around 11 years. This is very similar to that reported in a telephone survey of CFS-like illnesses in children in Chicago where the mean age at onset was 11.6 years (Reference Jordan, Ayers and JahnJordan et al, 2000). Thus, community surveys such as the present study appear to identify fatiguing illness of the same duration as those reported from specialist clinical services, although the children are on average at least 2 years younger.

Our study confirms the findings from other studies that chronic fatigue is rare in children under 10 years old (Reference MarshallMarshall, 1999). In addition, the gender ratio of approximately twice as many girls (67%) as boys (33%) reported with the symptom is also similar to other studies both of children and of adults (Reference Carter, Edwards and KronenbergerCarter et al, 1995; Reference Wessely, Chalder and HirschWessely et al, 1997).

Relationship of chronic fatigue in the twins to operationally defined CFS

Following the telephone interview we have found that chronic fatigue of the same duration, impairment and number of associated symptoms as the adult Centers for Disease Control operational definition of CFS (Reference Fukuda, Straus and HickieFukuda et al, 1994) has an estimated lifetime prevalence of 1.29%, whereas for a broader definition, including those with 3 months of symptom duration, a lifetime prevalence of 1.90% was found. The prevalence estimates for these ‘broad’ (3 months’ duration) and ‘narrow’ (6 months’ duration) definitions of chronic fatigue are not much different, which supports the view that the diagnosis of CFS in this younger age group should be made after 3 months of symptoms with impairment rather than after 6 months as the adult definition requires (Royal Colleges of Physicians, Psychiatrists and General Practitioners, 1996).

Despite not being formally diagnosed with CFS, the gender ratio (twice as many girls as boys), number and type of associated symptoms, frequency of co-occurring depression (just under 40%) and duration and impairment of chronic fatigue are little different in our population-based sample compared with those reported for clinical samples of young people diagnosed with CFS (Reference Feder, Dworkin and OrkinFeder et al, 1994; Reference Carter, Edwards and KronenbergerCarter et al, 1995; Reference Garralda and RangelGarralda & Rangel, 2001). It is also noteworthy that the percentage of subjects with co-occurring depressive disorder also increased with increasing duration of their chronic disabling fatigue.

Comparisons with another recently published epidemiological study of chronic fatigue in young people

Our prevalence estimates based on parental accounts are somewhat higher than the rates reported by Chalder and colleagues who undertook telephone interviews with 4240 children aged 11–15 years as part of a large epidemiological study of mental health in this age group (Reference Chalder, Goodman and WesselyChalder et al, 2003). They report a chronic fatigue prevalence of 0.57% (95% CI 0.34–0.80) whereas we have a ‘narrow’ definition prevalence of 1.29% (95% CI 0.87–1.71). However, from the published account of their study it would appear that they have determined point prevalence whereas in our study we have presented lifetime prevalence estimates.

Limitations of the study

Our study has a number of limitations. First, the results are based on an interview with a parent and not the child. Second, the interviewer was not a clinician so medical exclusions were based on obtaining a verbatim account of what the parent reported a doctor had said was the cause of fatigue in the twin and the advice of an independent clinician that the medical condition listed could entirely explain the chronic fatigue. Other conditions that could have partly explained the fatigue (e.g. viral infections) but not its severity or duration were retained in the analyses. Finally, because of the absence of a clinical examination of the twins, we have only reported on the resemblance of our subjects to CFS as defined by the Centers for Disease Control in terms of morbidity rather than the subjects fulfilling these criteria. Despite these caveats, our study has shown that the symptom pattern and severity, duration and associated impairment associated with chronic fatigue in young people are similar to those found in studies of adults with CFS (Reference Farmer, Chubb and JonesFarmer et al, 1996; Reference Wessely, Chalder and HirschWessely et al, 1997) and that prevalence estimates also fall within the range of 0.07–2.6% reported in studies of chronic fatigue in adults (Reference Bates, Schmiddt and LeeBates et al, 1993; Reference Buchwald, Umali and UmaliBuchwald et al, 1995; Reference Wessely, Chalder and HirschWessely et al, 1997).

Clinical Implications and Limitations

CLINICAL IMPLICATIONS

  1. From the age of 11 years, young people have the same prevalence, symptom profile, of 11 gender distribution, co-occurring depression and severity of fatiguing disorders as do adults.

  2. Chronic fatigue causes considerable impairment in young people, to both social development and time missed from school.

  3. Operational criteria for chronic fatigue syndrome (CFS) should require only 3 months’ symptom duration in young people and not 6 months as in adults.

LIMITATIONS

  1. Interviews were carried out by telephone, not face to face.

  2. The study presents parental accounts of fatigue rather than young people's own accounts.

  3. Interview questions were not validated in CFS clinic attenders or control subjects.

Footnotes

Declaration of interest

Funded by a grant from the PPP Charitable Trust (A. F. and A T)

References

American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). Washington, DC: APA.Google Scholar
Angold, A. & Costello, E. J. (1995) A test-retest reliability study of child-reported psychiatric symptoms and diagnoses using the Child and Adolescent Psychiatric Assessment (CAPA-C). Psychological Medicine, 25, 755762.CrossRefGoogle ScholarPubMed
Bates, D. Schmiddt, W., Lee, J., et al (1993) Prevalence of fatigue and chronic fatigue syndrome in primary and tertiary care. Archives of Internal Medicine, 153, 27592765.CrossRefGoogle Scholar
Bland, J. M. & Kerry, S. M. (1997) Statistics notes. Trial randomised into clusters. BMJ, 315, 600.CrossRefGoogle ScholarPubMed
Buchwald, D., Umali, P., Umali, J., et al (1995) Chronic fatigue and chronic fatigue syndrome: prevalence in a Pacific Northwest health care system. Annals of Internal Medicine, 123, 8188.CrossRefGoogle Scholar
Carter, B. D., Edwards, J. F., Kronenberger, W. G., et al (1995) Case control studies of chronic fatigue in pediatric patients. Pediatrics, 95, 179186.CrossRefGoogle ScholarPubMed
Chalder, T., Goodman, R., Wessely, S., et al (2003) Epidemiology of chronic fatigue syndrome and self reported myalgic encephalomyelitis in 5–15 year olds; a cross sectional study. BMJ, 327, 654655.CrossRefGoogle Scholar
Dowsett, E. G. & Colby, J. (1997) Long term sickness absence due to ME/CFS in UK schools: an epidemiological study with medical and educational implications. Journal of Chronic Fatigue Syndrome, 3, 2942.CrossRefGoogle Scholar
Farmer, A., Chubb, H., Jones, I., et al (1996) Screening for psychiatric morbidity in subjects presenting with chronic fatigue syndrome. British Journal of Psychiatry, 168, 354358.CrossRefGoogle ScholarPubMed
Feder, H. M., Dworkin, P. H. & Orkin, C. (1994) Outcome of 48 pediatric patients with chronic fatigue: a clinical experience. Archives of Family Medicine, 3, 10491055.CrossRefGoogle ScholarPubMed
Fukuda, K., Straus, S. E., Hickie, I., et al (1994) The chronic fatigue syndrome: a comprehensive approach to its definition and study. Annals of Internal Medicine, 121, 953959.CrossRefGoogle ScholarPubMed
Garralda, M. E. & Rangel, L. (2001) Childhood chronic fatigue syndrome (letter). American Journal of Psychiatry, 158, 1161.CrossRefGoogle Scholar
Jordan, K. M., Ayers, P. M., Jahn, S. C., et al (2000) Prevalence of fatigue and chronic fatigue syndrome like illness in children and adolescents. Journal of Chronic Fatigue Syndrome, 6, 321.CrossRefGoogle Scholar
Marshall, G. S. (1999) Report of a workshop on the epidemiology, natural history and pathogenesis of chronic fatigue syndrome in adolescents. Journal of Pediatrics, 134, 395405.CrossRefGoogle ScholarPubMed
Rice, F., Harold, G. T. & Thapar, A. (2002) Assessing the effects of age, sex and shared environment on the genetic aetiology of depression in childhood and adolescence. Journal of Child Psychology and Psychiatry, 43, 10391051.CrossRefGoogle ScholarPubMed
Royal Colleges of Physicians, Psychiatrists and General Practitioners (1996) Chronic Fatigue Syndrome. Report of a Joint Working Group (Council Report CR54). London: Royal College of Physicians Publications Unit.Google Scholar
Scourfield, J., Martin, N., Lewis, G., et al (1999) Heritability of social cognitive skills in children and adolescents. British Journal of Psychiatry, 175, 559564.CrossRefGoogle ScholarPubMed
Sharpe, M. & Wilks, D. (2002) Fatigue. BMJ, 325, 480483.CrossRefGoogle ScholarPubMed
Skapinakis, P., Lewis, G. & Meltzer, H. (2000) Clarifying the relationship between unexplained chronic fatigue and psychiatric morbidity: results from a community survey in Great Britain. American Journal of Psychiatry, 157, 14921498.CrossRefGoogle ScholarPubMed
Thapar, A., Harrington, R., Ross, K., et al (2000) Does the definition of ADHD affect heritability? Journal of the American Academy of Child and Adolescent Psychiatry, 39, 15281536.CrossRefGoogle ScholarPubMed
Wessely, S., Chalder, T., Hirsch, S., et al (1997) The prevalence and morbidity of chronic fatigue syndrome: a prospective primary care study. American Journal of Public Health, 87, 14491455.CrossRefGoogle ScholarPubMed
Figure 0

Fig. 1 Flow chart of subject inclusions and exclusions in the study (Qs, questionnaires; GP. general practitioner).

Figure 1

Table 1 Frequencies of symptoms associated with prolonged fatigue in boys and girls

Figure 2

Table 2 Number of fatigued boys and girls, mean age at onset and % with comorbid depression for five categories: any duration, at least 1 month, 3 months or more, 3 months and at least four minor symptoms and 6 months or more and at least four minor symptoms

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