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An Inverse Correlation between Spontaneous Eye-Blink Rate and Platelet Monoamine Oxidase Activity

Published online by Cambridge University Press:  29 January 2018

Craig N. Karson ,
Joel E. Kleinman ,
Karen Faith Berman ,
Bruce H. Phelps ,
C. D. Wise ,
Lynn E. DeLisi  and
Dilip V. Jeste
Craig N. Karson
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
Joel E. Kleinman
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
Karen Faith Berman
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
Bruce H. Phelps
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
C. D. Wise
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
Lynn E. DeLisi
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
Dilip V. Jeste
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
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Summary

An inverse correlation between platelet monoamine oxidase activity and spontaneous eye-blink rate, a putative measure of central dopaminergic activity, was found in medication-free chronic schizophrenic patients without tardive dyskinesia (n = 20, rs = -.47, P <.025). A similar correlation was found when patients with tardive dyskinesia were included but was weaker (n = 27, rs = -.35, P <.05). Normal controls and patients with tardive dyskinesia did not demonstrate this relationship. This report confirms a previous finding of a significant platelet monoamine oxidase-blink rate correlation in chronic schizophrenic patients. Insofar as this relationship is mediated by dopamine, it suggests that dopaminergic relations are more readily demonstrated in schizophrenic subjects than normals. Moreover, tardive dyskinesia appears to obscure this dopaminergic relationship.

Type
Papers
Information
The British Journal of Psychiatry , Volume 142 , Issue 1 , January 1983 , pp. 43 - 46
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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