APOE-4 Genotype and Neurophysiological Vulnerability to Alzheimer's and Cognitive Aging

Susan Bookheimer; Alison Burggren

doi:10.1146/annurev.clinpsy.032408.153625

Annual Review of Clinical Psychology

Volume 5, 2009

Review Article

APOE-4 Genotype and Neurophysiological Vulnerability to Alzheimer's and Cognitive Aging

Susan Bookheimer^1,2, and Alison Burggren¹
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Affiliations: ¹Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Department of Psychology, University of California, Los Angeles, California 90095; email: [email protected] ²Department of Psychology, University of California, Los Angeles, California 90095;
Vol. 5:343-362 (Volume publication date April 2009) https://doi.org/10.1146/annurev.clinpsy.032408.153625
First published as a Review in Advance on January 20, 2009
© Annual Reviews

Abstract

Many years before receiving a clinical diagnosis of Alzheimer's disease (AD), patients experience evidence of cognitive decline. Recent studies using a variety of brain imaging technologies have detected subtle changes in brain structure and function in normal adults with a genetic risk for AD; these brain changes have similar pathological features as AD, and some appear to be predictive of future cognitive decline. This review examines the most recent data on brain changes in genetic risk for AD and discusses the benefits and potential risks of detecting individuals at risk.

Keyword(s): dementia, functional MRI (fMRI), neuroimaging

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2009-04-27

2024-04-19