Regular Research ArticlesReduced Quality-of-Life Ratings in Mild Cognitive Impairment: Analyses of Subject and Informant Responses
Section snippets
Research Participants
Subjects were drawn from an ongoing research study coordinated through the Easton Center for Alzheimer's Disease Research at the University of California, Los Angeles (UCLA). Participants meeting criteria for MCI (n = 108) were recruited from patients assessed in the Memory Disorders Clinics at the UCLA Medical Center, Olive View-UCLA Medical Center, and Marina Campus of the Centinela-Freeman Medical Center. The normal comparison group (NC; n = 97) included individuals initially seen in the
RESULTS
Demographic, cognitive, neuropsychiatric, and functional comparisons between the NC and MCI groups are shown in Table 1. The two groups were similar in age, level of education, and gender and ethnic distribution. Analyses of cognitive data indicated that the MCI group performed more poorly on the MMSE and in each of the domains that were assessed. The MCI group exhibited greater neuropsychiatric symptoms (as measured by the NPI) than the NC group, but did not report higher levels of depression
DISCUSSION
Our results indicate that individuals meeting criteria for MCI have modest decreases in QOL relative to age-matched cognitively normal older adults. Reductions in global QOL-AD indices in our MCI cohort were driven by decreased ratings for the mood and memory items on both subject and informant questionnaires. These findings are consistent with a prior study that showed impaired psychological (but not physical, social relationship, or environmental) QOL in MCI subjects using the short version
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This research was supported by grants from the National Institute on Aging (P50 AG 16570, K23 AG 028727 [to PL], and K08 AG 34628 [to ET; jointly sponsored by NIA, AFAR, the John A. Hartford Foundation, the Atlantic Philanthropies, the Starr Foundation and an anonymous donor]), the Alzheimer's Disease Research Centers of California, and the Sidell-Kagan Foundation.
Disclosures: No disclosures to report.