Regular Research ArticlesCardiovascular Risk Profile and Subsequent Disability and Mental Well-being: The Zutphen Elderly Study
Section snippets
Study Sample
The cohort of the Zutphen Elderly Study consists of men born between 1900 and 1920. The Zutphen Study started in 1960 as the Dutch contribution to the Seven Countries Study on life style, biological risk factors, and CVD in middle-aged men.27 In 1985, 367 of 555 men who were still alive were reexamined. In addition, a new random sample of 711 men of the same age also living in Zutphen but not belonging to the original cohort was invited to participate. The invitation resulted in a total target
Baseline Characteristics
The 342 men who were excluded differed from 545 participating men, as they were older (73.2 ± 5.5 versus 71.7 ± 5.2 years; t (885) = 3.93, p <0.001), were less physically active (geometric mean 210 versus 343 minute per week; t (466) = −3.64, p <0.001), were more often using antihypertensive medication (15.8 versus 9.5%; χ2(1) = 7.80, p = 0.005).
Regarding the risk status, there were 1) 44 (8.1%) men with a BMI ≥30.0 kg/m2, 2) 246 (45.1%) men presently smoking, 3) 210 (38.5%) men with
DISCUSSION
We found that combined “classic” cardiovascular risk factors are predictive of functional disability, but not of mental well-being during follow-up in elderly, community-living men. More specifically, after adjusting for dispositional optimism (and thereby adjusted for a measure of baseline mental well-being), the cardiovascular risk factor status was not associated with an increased risk of depressive symptoms. Our findings are not in line with the hypothesis that “classic” cardiovascular risk
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Depressive symptoms and dispositional optimism in relation to mortality in older post-myocardial infarction patients
2021, Journal of Affective Disorders ReportsCitation Excerpt :The scores range from 0 to 8 points, with higher scores being indicative of higher optimism levels. A cut-off score <6 was used to indicate low dispositional optimism (Giltay et al., 2008). The Cronbach's alpha was 0.61 in our sample.
The association between Dietary Inflammatory Index and disability in older adults
2021, Clinical NutritionCitation Excerpt :Dietary Inflammatory Index (DII) was developed to assess the inflammatory effect of diet on health [14], which has been demonstrated to strongly correlate with several inflammatory markers such as CRP, IL-6, and homocysteine [15,16]. Prior studies have investigated the associations between DII and various health outcomes, including frailty [17], cardiovascular diseases [18], and type 2 diabetes mellitus [19], which are risk factors of disability [20–22]. Moreover, DII was fairly consistently associated with cognitive impairment [23,24], which, in turn, could impact functional disability [25].
Late-life depression, cortisol, and the metabolic syndrome
2009, American Journal of Geriatric PsychiatryCitation Excerpt :One study in the older general population reported only a weak association between depressive symptoms and metabolic syndrome in white persons only.15 Also, Giltay et al.16 showed in an older general population that persons who scored high on “classic” cardiovascular risk factors related to the metabolic syndrome, such as obesity, hypertension, hypercholesterolemia, and diabetes, did not report more depressive symptoms than persons who scored low on these risk factors. Possibly, in a more diffuse general older population, associations are not as clear.
Memantine dosing in patients with dementia
2009, American Journal of Geriatric PsychiatryThe curiously strong relationship between cardiovascular disease and depression in the elderly
2008, American Journal of Geriatric Psychiatry
The Zutphen Elderly Study was supported by the Netherlands Prevention Foundation (Praeventiefonds).