Journal of the American Academy of Child & Adolescent Psychiatry
ReviewMeta-Analysis: Treatment of Attention-Deficit/Hyperactivity Disorder in Children With Comorbid Tic Disorders
Section snippets
Search Strategy for Identification of Studies
Two reviewers searched PubMed for relevant studies using the search “attention-deficit disorder with hyperactivity (MeSH) or ADHD or ADDH or hyperactive* or hyperkin* or “attention-deficit*” or ‘brain dysfunction’” and “tic disorders (MeSH) or Tourette* or tic.” The search was further limited to randomized clinical trials and meta-analyses. The references of included articles, as well as review articles and meta-analyses in this area, were searched for citations of further relevant published
Included Studies
We included nine studies involving 477 subjects (177 in crossover studies) in our analysis.33, 34, 35, 36, 37, 38, 39, 40, 41 Four studies, involving 191 subjects (122 in crossover studies), compared methylphenidate-derivatives with placebo.33, 34, 35, 38 Three studies, involving 134 subjects (34 in crossover studies), compared α-agonist medications with placebo.36, 38, 39 Two studies, involving 75 subjects (34 in crossover studies), compared desipramine with placebo.39, 40 One study, involving
Discussion
Meta-analysis of randomized placebo-controlled trials in the children with ADHD and comorbid tics demonstrated that methylphenidate, alpha-2 agonists, desipramine, and atomoxetine have shown efficacy in treating ADHD symptoms. Furthermore, none of these four medications seemed to worsen tic severity. Alpha-2 agonists and atomoxetine have demonstrated statistically significant improvement in tic symptoms with treatment, whereas both methylphenidate and desipramine demonstrated improvement in tic
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Cited by (180)
Pharmacologic Treatment of Comorbid Attention-Deficit/Hyperactivity Disorder and Tourette and Tic Disorders
2022, Child and Adolescent Psychiatric Clinics of North AmericaPrevalence of tics among attention deficit hyperactivity disorder children treated with methylphenidate
2022, Neuropsychiatrie de l'Enfance et de l'AdolescenceCitation Excerpt :The outcomes of the study showed that the drug may be effective for short term treatment of ADHD however, may worsen tic-related signs. Bloch and colleagues, in a meta-analysis, found that methylphenidate did not appear to worsen the symptoms of tics [26]. Our study does not evaluate tic disorder and long-term effect of the drug.
Attention-deficit/hyperactivity disorder
2024, Nature Reviews Disease PrimersMethylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
2023, Cochrane Database of Systematic ReviewsAn updated safety review of the current drugs for managing ADHD in children
2023, Expert Opinion on Drug Safety
This article was reviewed under and accepted by Deputy Editor John T. Walkup, M.D.
All of the authors are with the Yale Child Study Center, Yale University School of Medicine.
The authors acknowledge the National Institute of Mental Health support of the Yale Child Study Center Research Training Program (M.H.B. and J.F.L.), K05MH076273 (J.F.L.), the National Institute of Health Loan Repayment Program (M.H.B.), the support of the Tourette's Syndrome Association (J.F.L.), the APIRE/Eli Lilly Psychiatric Research Fellowship (M.H.B.), and the APA/NIMH PMRTP Program (A.L.W.).
This article is the subject of an editorial by Dr. Eric Taylor in this issue.