Journal of the American Academy of Child & Adolescent Psychiatry
CBCL Pediatric Bipolar Disorder Profile and ADHD: Comorbidity and Quantitative Trait Loci Analysis
Section snippets
Subjects
Study subjects were 540 children and adolescents ages 5 to 18 years (mean 10.6, SD 3.2) and 519 of their parents ascertained from 270 families with ADHD-affected sibling pairs. Families were included if at least one child met full DSM-IV ADHD criteria and a second child had a diagnosis of definite or probable ADHD, defined as being no more than one symptom short of full criteria, but with evidence of impairment in two settings. All of the families were English speaking. Mean socioeconomic
Results
Subjects' mean (SD) age was 10.6 (3.2) years. Twenty-seven percent of ADHD subjects had increases (T > 70) on the AP subscale, with 31% of these, or 8% of the entire sample, also showing increases on AGG and AD subscales. Sibling scores on the quantitative CBCL-PBD phenotype were highly correlated, with Pearson's r = 0.44 (p < .0001). Of 270 families, 42 (16%) had at least one child meeting CBCL-PBD criteria. The occurrence of bipolar spectrum illness was low in the entire sample, with rates of
Discussion
In a genetically enriched sample of ADHD affected sibling pairs, the CBCL-PBD profile identified a small (8%) but distinct subset of individuals with severe psychopathology. These results are consistent with an earlier report describing similarly increased rates of oppositional defiant, conduct, and anxiety disorders in clinical samples.2 Also in other reports, the CBCL-PBD profile identified increased ADHD, oppositional defiant disorder, conduct disorder, and suicidality in a population-based
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Shared and Distinct Neurobiological Bases of Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder in Children and Adolescents: A Comparative Meta-analysis of Structural Abnormalities
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2021, Journal of Affective DisordersClinical utility of the CBCL Dysregulation Profile in children with disruptive behavior
2019, Journal of Affective DisordersCitation Excerpt :For example, children with elevated CBCL-DP scores have higher rates of suicidal ideation and behaviors (Althoff et al., 2006) and higher rates of psychiatric disorders than their peers (McGough et al., 2008; Spencer et al., 2011; Volk and Todd, 2007). The CBCL-DP also appears to identify children at risk for a range of affective disorders, including anxiety disorders and mood disorders, concurrently and longitudinally (Althoff et al., 2010; McGough et al., 2008; Meyer et al., 2009; Spencer et al., 2011). Evidence of the concurrent or criterion validity of the CBCL-DP in clinic-referred children with disruptive behavior is currently limited.
Genome-wide QTL analysis for anxiety trait in bipolar disorder type I
2018, Journal of Affective DisordersInternational Comparisons of the Youth Self-Report Dysregulation Profile: Latent Class Analyses in 34 Societies
2016, Journal of the American Academy of Child and Adolescent PsychiatryCitation Excerpt :Previous research has indicated that the CBCL-DP has a different genetic architecture than that of any of its constituent syndromes alone.20 In addition, McGough et al.21 reported different genetic markers associated with the CBCL-DP than with bipolar disorder, depression, or attention problems. What is not clear, however, is whether such genetic findings—or outcome findings—for the DP are specific to elevations on just the 3 constituent syndromes or rather are due to the fact that children in the DP class have high scores on most of the 8 syndromes.
This work was supported by National Institute of Mental Health grants MH01969 (to J.J.M.), HD40275 (to S.K.L.), MH01805 (to J.T.M.), MH071852 (to S.F.N.), and MH58277 (to S.L.S.).
The authors dedicate this article to the memory of Richard D. Todd, M.D., Ph.D. (1951–2008).