Journal of the American Academy of Child & Adolescent Psychiatry
ARTICLESTemporal Lobe Anatomy and Psychiatric Symptoms in Velocardiofacial Syndrome (22q11.2 Deletion Syndrome)
Section snippets
Participants
Herein, we report on 80 children between the ages of 9 and 15 years. The age-matched sample for these analyses consisted of 47 children with VCFS (22 males, mean age, 11.7 [SD = 2.1]; mean IQ, 71.2 [SD = 12.3]), 18 unaffected children (12 males, mean age, 11.5 [SD = 2.0]; mean IQ, 90.3 [SD = 12.1]), and 15 unaffected siblings (five males, mean age, 11.5 [SD = 1.8]; mean IQ, 102.4 [SD = 12.7]).
Families of children with VCFS were recruited through advertisements in the VCFS Educational Foundation
Relationship Between Whole Brain Volume and Regions of Interest
Whole brain volume was significantly smaller in children with VCFS relative to controls (F 1,78 = 5.1; p =.03; η2 = 0.06). In addition, whole brain volume was significantly correlated with hippocampus, amygdala, and prefrontal cortex volumes in both study groups (data not shown). Whole brain was also associated with prefrontal cortex/hippocampus and prefrontal cortex/amygdala ratios in both study groups (data not shown). Accordingly, we covaried for whole brain volume for all neuroanatomic
DISCUSSION
This study demonstrated that volumes of mesial temporal lobe structures are altered in children and adolescents with VCFS and that alterations in amygdala volume are associated with more psychiatric symptoms in children with this genetic disorder. Comparable to a previous study of mesial temporal lobe structures in VCFS (Eliez et al., 2001), participants with VCFS exhibited smaller hippocampal volumes that were proportionate to overall reductions in whole brain volume. In contrast to previous
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This research was supported by National Institutes of Health awards MH64824 and MH65481 to Dr. Kates. In addition, the authors are grateful to Robert J. Shprintzen, Ph.D., Anne Marie Higgins, N.P., and the children and families who participated.
Disclosure: Dr. Fremont is funded by Pfizer as part of a multisitestudy of the effectiveness of Zoloft to treat posttraumatic stress disorderin children. The other authors have no financial relationships to disclose.