Embolotherapy of Pulmonary Arteriovenous Malformations: Long-term Results in 112 Patients
Section snippets
MATERIALS AND METHODS
The study was performed after approval of the medical review board of our hospital.
Overall Results
The study group consisted of 112 patients, 44 men and 68 women, with a mean age of 44.9 years (range, 7–85 years). The mean follow-up was 62.2 months (range, 9 –145 months). Initially, 296 PAVMs were embolized in one or two sessions in 110 patients and in three sessions in two patients. Nineteen patients underwent a second treatment and four underwent a third. In total, 349 PAVMs were embolized in 157 sessions.
The mean value of right-to-left shunts decreased from 18.5% (SD, 8.6%) to 7.3% (SD,
DISCUSSION
The goals of treatment of PAVMs are prevention of hemorrhage, improvement of hypoxemia, and, most importantly, prevention of the complications that are associated with the local absence of the pulmonary capillary filter. It is estimated that 24% of patients with PAVMs experience TIA or stroke and 9% experience cerebral abscess on presentation of PAVMs (1). In 76 consecutive patients, White and colleagues (5) reported TIAs in 37%, strokes in 18%, and cerebral abscesses in 9% before
Acknowledgments
The authors thank P. Zanen for his help in the statistical analysis.
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This study was financially supported by the Janivo Foundation, the Mr. Willem Bakhuys Roozeboom Foundation, and Glaxo SmithKline, The Netherlands. None of the authors have identified a conflict of interest.