Original Article
Are Perinatal Complications Relevant to the Manifestation of ADD? Issues of Comorbidity and Familiality

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ABSTRACT

Objective

We evaluated the role of pregnancy, delivery, and infancy complications (PDICs) in the etiology of attention deficit disorder (ADD) addressing issues of comorbidity and familiality by formulating and testing multiple hypotheses.

Method

Subjects were six to 17-year-old boys with DSM-III attention deficit disorder (ADD, N = 73), psychiatric (N = 26), and normal (N = 26) controls and their relatives. Information on PDICs was obtained from the mothers in a standardized manner blind to the proband's clinical status.

Results

Using odds ratio analyses, an association was found between ADD and PDICs that was strongest for the comorbid and nonfamilial subtypes. In contrast, noncomorbid and familial ADD subgroups differed less from normal controls in the risk for PDICs.

Conclusions

The increased risk for PDICs in nonfamilial ADD children and the lack of evidence for increased risk among familial ADD patients suggests that PDICs may be part of nongenetic etiologic mechanisms in this disorder, especially for children who have comorbid disorders. J. Am. Acad. Child Adolesc. Psychiatry, 1993, 32, 5:1032–1037.

REFERENCES (31)

  • J. Biederman et al.

    Evidence of familial association between attention deficit disorder and major affective disorders

    Arch. Gen. Psychiatry

    (1991)
  • H.R. Bird et al.

    Estimates of the prevalence of childhood maladjustment in a community survey in Puerto Rico

    Arch. Gen. Psychiatry

    (1988)
  • D.P. Cantwell

    Psychiatric illness in the families of hyperactive children

    Arch. Gen. Psychiatry

    (1972)
  • L.F. Colletti

    Relationship between pregnancy and birth complications and the later development of learning disabilities

    Journal of Learning Disabilities

    (1979)
  • C.K. Conners

    Controlled trial of methylphenidate in preschool children with minimal brain dysfunction

    International Journal of Mental Health

    (1975)
  • Cited by (0)

    This work was supported, in part, byUSPHS (NIMH) grant RO1 MH-41314–01A2(J.B.).

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