Minireviews
Cardiac Z-disc Signaling Network*

https://doi.org/10.1074/jbc.R110.174268Get rights and content
Under a Creative Commons license
open access

During the last 15 years, the perception of the cardiac z-disc has undergone substantial changes. Initially viewed as a structural component at the lateral boundaries of the sarcomere, the cardiac z-disc has increasingly become recognized as a nodal point in cardiomyocyte signal transduction and disease. This minireview thus focuses on novel components and recent developments in z-disc biology and their role in cardiac signaling and disease.

Calcineurin
Cardiac Muscle
Cytoskeleton
Nuclear Translocation
Signal Transduction
Sarcomere
Z-disc

Cited by (0)

*

This work was supported by a grant from the Bundesministerium für Bildung und Forschung (Nationales Genomforschungsnetz NGFNplus; to N. F.) and by a grant from the Hengstberger Stiftung/German Society of Cardiology (DGK; to D. F.). This is the first article in the Thematic Minireview Series on Signaling in Cardiac Sarcomeres in Health and Disease. This minireview will be reprinted in the 2011 Minireview Compendium, which will be available in January, 2012.

© 2011 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.