Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
EndodonticsEffect of systemic penicillin on pain in untreated irreversible pulpitis*,**
Section snippets
Patients and methods
Forty adult patients presenting for emergency treatment participated in this study. All patients were in good health as determined by a written health history and oral questioning. Subjects were not taking antibiotics and had not received them within 30 days before participation in the study. This study was approved by The Ohio State University Human Subjects Committee, and written consent was obtained from each patient.
Each patient included in this study had a tooth with a clinical diagnosis
Results
Each group consisted of 20 patients. The distribution of tooth type is found in Table I.
Table II shows the initial values of age, sex, weight, initial pain, and initial percussion pain for the 2 groups.
The pain ratings are summarized in Table III.The SPID between the penicillin and placebo groups was not statistically significant (Table IV, P =.776).As shown in Table III, 100% (40 of 40) of the subjects presented with moderate to severe pain ratings at the baseline. For both groups, the mean
Discussion
The administration of penicillin did not significantly (P >.05) reduce pain, percussion pain, or the number of analgesic medications taken by patients with untreated irreversible pulpitis. Although bacteria are important in the pathogenesis of irreversible pulpitis caused by caries, Massler and Pawlack1 and Torneck2 established that pulps of teeth with irreversible pulpitis and without a clinical pulpal exposure contained no demonstrable bacteria. Early stages of irreversible pulpitis represent
References (20)
- et al.
The affected and infected pulp
Oral Surg Oral Med Oral Pathol
(1977) A report of studies into changes in the fine structure of the dental pulp in human caries pulpitis
J Endod
(1981)- et al.
Microbiological studies of carious dentine from human teeth with irreversible pulpitis
Arch Oral Biol
(1991) - et al.
Antibodies in normal and diseased pulps reactive with microorganisms isolated from deep caries
J Endod
(1992) - et al.
Detection of human IL-2 in normal and inflamed dental pulps
J Endod
(1997) - et al.
Stimulation of interleukin-6 production in human pulp cells by peptidoglycans from Lactobacillus casei
J Endod
(1998) - et al.
Increased interleukin-8 expression in inflamed human dental pulps
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(1999) - et al.
Postoperative pain incidence related to the type of emergency treatment of symptomatic pulpitis
Oral Surg Oral Med Oral Pathol
(1992) - et al.
Penicillin as a supplement in resolving the localized acute apical abscess
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(1996) - et al.
An evaluation of volumes and concentrations of lidocaine in human inferior alveolar nerve block
J Endod
(1989)
Cited by (71)
Assessing the impact of an urgent dental care centre on the oral health-related quality of life of patients during the COVID-19 pandemic
2021, Advances in Oral and Maxillofacial SurgeryAntibiotic Use in 2016 by Members of the American Association of Endodontists: Report of a National Survey
2017, Journal of EndodonticsAAE Position Statement: AAE Guidance on the Use of Systemic Antibiotics in Endodontics
2017, Journal of EndodonticsOral Health Care for Nurse Educator, Part 2: The School Year: 6 Years Old to Young Adult
2017, Teaching and Learning in Nursing
- *
Supported by research funding from the Endodontic Graduate Student Research Fund and the Steve Goldberg Memorial Fund, The Ohio State University.
- **
Reprint requests: Al Reader, DDS, MS, Graduate Endodontics, College of Dentistry, PO Box 182357, The Ohio State University, 305 W 12th Ave, Columbus, OH 43218-2357