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Horm Metab Res 2012; 44(02): 146-151
DOI: 10.1055/s-0031-1297262
Humans, Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Effects of an 8-Week Aerobic Exercise Training on Saliva Steroid Hormones, Physical Capacity, and Quality of Life in Diabetic Obese Men

A. Baillot
1   Laboratoire AMAPP, EA 4248, Université d’Orléans, Orléans, France
2   Centre de Recherche Clinique Étienne LeBel, Faculté de médecine et des sciences de la santé, CHU Sherbrooke, Québec, Canada
,
N. Vibarel-Rebot
1   Laboratoire AMAPP, EA 4248, Université d’Orléans, Orléans, France
3   CIAMS-RIME, Université Paris XI, Paris, France
,
V. Amiot
1   Laboratoire AMAPP, EA 4248, Université d’Orléans, Orléans, France
4   Service de Médecine du Sport, CHR Orléans, Orléans, France
,
P. Emy
5   Service d’Endocrinologie, CHR Orléans, Orléans, France
,
K. Collomp
1   Laboratoire AMAPP, EA 4248, Université d’Orléans, Orléans, France
3   CIAMS-RIME, Université Paris XI, Paris, France
6   Département des Analyses, AFLD, Chatenay-Malabry, France
› Author Affiliations
Further Information

Publication History

received 27 June 2011

accepted 10 November 2011

Publication Date:
15 December 2011 (online)

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Abstract

The purpose of the study was to assess the effects of aerobic exercise training on saliva steroid hormones [i. e., cortisol, dehydroepiandrosterone (DHEA), and testosterone], physical capacity, and quality of life in obese diabetic men. 8 abdominally obese type 2 diabetic men (59.5±1.7 years old, BMI=35.5±1.6 kg/m2, waist circumference=119.4±3.3 cm) and 9 healthy men (57.4±1.5 years old, BMI=24.5±0.8 kg/m2, waist circumference=92.3±1.9 cm) participated in the study. The obese diabetic men underwent 8 weeks of aerobic exercise training: twice a week 45 min sessions at 75% of peak heart rate and once a week 45 min session of intermittent exercise. Before and after training, steroid hormone concentrations were analyzed from saliva samples, physical capacity was assessed by the 6-minute walking test, and quality of life was estimated by a specific questionnaire for obese subjects. These data were compared with the data from the healthy untrained men. The basal saliva DHEA and testosterone concentrations, physical capacity, and quality of life scores of the obese diabetic men were significantly lower than those of the healthy men. Aerobic training induces a significant increase in the 6-min walking distance and improve the psychosocial impact dimension of quality of life, without modifying significantly any other parameter investigated. These data suggest that an 8-week aerobic exercise program improves physical capacity and quality of life in obese diabetic men, but was insufficient to correct the anthropometric and hormonal alterations observed in this population.

Key words

physical activity - cortisol - DHEA - testosterone - 6-minute walking test
 

  • References

  • 1 Björntorp P. Body fat distribution, insulin resistance, and metabolic diseases. Nutrition 1997; 13: 795-803
    CrossrefPubMedGoogle Scholar
  • 2 Whitworth JA, Williamson PM, Mangos G, Kelly JJ. Cardiovascular consequences of cortisol excess. Vasc Health Risk Manag 2005; 1: 291-299
    CrossrefPubMedGoogle Scholar
  • 3 Tchernof A, Labrie F. Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies. Eur J Endocrinol 2004; 151: 1-14
    CrossrefPubMedGoogle Scholar
  • 4 Kaplan SA, Meehan AG, Shah A. The age related decrease in testosterone is significantly exacerbated in obese men with the metabolic syndrome. What are the implications for the relatively high incidence of erectile dysfunction observed in these men?. J Urol 2006; 176: 1524-1528
    CrossrefPubMedGoogle Scholar
  • 5 Ibáñez J, Gorostiaga EM, Alonso AM, Forga L, Argüelles I, Larrión JL, Izquierdo M. Lower muscle strength gains in older men with type 2 diabetes after resistance training. J Diabetes Complicat 2008; 22: 112-118
    CrossrefPubMedGoogle Scholar
  • 6 Boulé NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA 2001; 286: 1218-1227
    CrossrefPubMedGoogle Scholar
  • 7 Whelton SP, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med 2002; 136: 493-503
    CrossrefPubMedGoogle Scholar
  • 8 Katzmarzyk PT, Leon AS, Wilmore JH, Skinner JS, Rao DC, Rankinen T, Bouchard C. Targeting the metabolic syndrome with exercise: evidence from the HERITAGE Family Study. Med Sci Sports Exerc 2003; 35: 1703-1709
    CrossrefPubMedGoogle Scholar
  • 9 Kelley GA, Kelley KS, Vu Tran Z. Aerobic exercise, lipids and lipoproteins in overweight and obese adults: a meta-analysis of randomized controlled trials. Int J Obes (Lond) 2005; 29: 881-893
    CrossrefPubMedGoogle Scholar
  • 10 Lee S, Kuk JL, Davidson LE, Hudson R, Kilpatrick K, Graham TE, Ross R. Exercise without weight loss is an effective strategy for obesity reduction in obese individuals with and without Type 2 diabetes. J Appl Physiol 2005; 99: 1220-1225
    CrossrefPubMedGoogle Scholar
  • 11 Erdmann J, Tholl S, Schusdziarra V. Effect of carbohydrate- and protein-rich meals on exercise-induced activation of lipolysis in obese subjects. Horm Metab Res 2010; 42: 290-294
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Marion-Latard F, Crampes F, Zakaroff-Girard A, De Glisezinski I, Harant I, Stich V, Thalamas C, Rivière D, Lafontan M, Berlan M. Post-exercise increase of lipid oxidation after a moderate exercise bout in untrained healthy obese men. Horm Metab Res 2003; 35: 97-103
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Björntorp P, Holm G, Jacobsson B, Schiller-de-Jounge K, Lundberg PA, Sjöström L, Smith U, Sullivan L. Physical training in human hyperplastic obesity. IV. Effects on the hormonal status. Metab Clin Exp 1977; 26: 319-328
    CrossrefPubMedGoogle Scholar
  • 14 Kraemer WJ, Volek JS, Clark KL, Gordon SE, Puhl SM, Koziris LP, McBride JM, Triplett-McBride NT, Putukian M, Newton RU, Häkkinen K, Bush JA, Sebastianelli WJ. Influence of exercise training on physiological and performance changes with weight loss in men. Med Sci Sports Exerc 1999; 3: 1320-1329
    PubMedGoogle Scholar
  • 15 Boudou P, De Kerviler E, Vexiau P, Fiet J, Cathelineau G, Gautier J. Effects of a single bout of exercise and exercise training on steroid levels in middle-aged type 2 diabetic men: relationship to abdominal adipose tissue distribution and metabolic status. Diabetes Metab 2000; 26: 450-457
    PubMedGoogle Scholar
  • 16 Hinton PS, Rector RS, Thomas TR. Weight-bearing, aerobic exercise increases markers of bone formation during short-term weight loss in overweight and obese men and women. Metab Clin Exp 2006; 55: 1616-1618
    CrossrefPubMedGoogle Scholar
  • 17 Tauber JP. Quality of life and non-insulin-dependent diabetes. Diabetes Metab 1997; 23 (Suppl) 444-448
    PubMedGoogle Scholar
  • 18 Kolotkin RL, Meter K, Williams GR. Quality of life and obesity. Obes Rev 2001; 2: 219-229
    CrossrefPubMedGoogle Scholar
  • 19 Liu X, Miller YD, Burton NW, Brown WJ. Preliminary study of the effects of Tai Chi and Qigong medical exercise on indicators of metabolic syndrome and glycaemic control in adults with raised blood glucose levels. Br J Sports Med 2009; 43: 840-844
    CrossrefPubMedGoogle Scholar
  • 20 Levinger I, Goodman C, Hare DL, Jerums G, Selig S. The effect of resistance training on functional capacity and quality of life in individuals with high and low numbers of metabolic risk factors. Diabetes Care 2007; 30: 2205-2210
    CrossrefPubMedGoogle Scholar
  • 21 Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003; 35: 1381-1395
    CrossrefPubMedGoogle Scholar
  • 22 Tehard B, Saris WH, Astrup A, Martinez JA, Taylor MA, Barbe P, Richterova B, Guy-Grand B, Sørensen TI, Oppert JM. Comparison of two physical activity questionnaires in obese subjects: the NUGENOB study. Med Sci Sports Exerc 2005; 37: 1535-1541
    CrossrefPubMedGoogle Scholar
  • 23 Enright PL, Sherrill DL. Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med 1998; 158: 1384-1387
    CrossrefPubMedGoogle Scholar
  • 24 Baillot A, Vibarel-Rebot N, Lecoq A, Chadenas D. Six-minute walking test in obese female: Reproducibility, relative intensity and relationship with quality of life. Sci Sports 2009; 24: 1-8
    CrossrefPubMedGoogle Scholar
  • 25 Beriault K, Carpentier AC, Gagnon C, Ménard J, Baillargeon JP, Ardilouze JL, Langlois MF. Reproducibility of the 6-minute walk test in obese adults. Int J Sports Med 2009; 30: 725-727
    Article in Thieme ConnectPubMedGoogle Scholar
  • 26 ATS Statement . Guidelines for the Six-Minute Walk Test. Am J Respir Crit Care Med 2002; 166: 111-117
    CrossrefPubMedGoogle Scholar
  • 27 Ziegler O, Filipecki J, Girod I, Guillemin F. Development and validation of a French obesity-specific quality of life questionnaire: Quality Of Life, Obesity and Dietetics (QOLOD) rating scale. Diabetes Metab 2005; 31: 273-283
    CrossrefPubMedGoogle Scholar
  • 28 Catenacci VA, Wyatt HR. The role of physical activity in producing and maintaining weight loss. Nat Clin Pract Endocrinol Metab 2007; 3: 518-529
    CrossrefPubMedGoogle Scholar
  • 29 Ross R, Janssen I, Dawson J, Kungl A, Kuk JL, Wong SL, Nguyen-Duy T, Lee S, Kilpatrick K, Hudson R. Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obes Res 2004; 12: 789-798
    CrossrefPubMedGoogle Scholar
  • 30 Giannopoulou I, Ploutz-Snyder LL, Carhart R, Weinstock RS, Fernhall B, Goulopoulou S, Kanaley JA. Exercise is required for visceral fat loss in postmenopausal women with type 2 diabetes. J Clin Endocrinol Metab 2005; 90: 1511-1518
    PubMedGoogle Scholar
  • 31 Salvadori A, Fanari P, Fontana M, Buontempi L, Saezza A, Baudo S, Miserocchi G, Longhini E. Oxygen uptake and cardiac performance in obese and normal subjects during exercise. Respiration 1999; 66: 25-33
    CrossrefPubMedGoogle Scholar
  • 32 Özdirenç M, Biberoglu S, Özcan A. Evaluation of physical fitness in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2003; 60: 171-176
    CrossrefPubMedGoogle Scholar
  • 33 Redelmeier DA, Bayoumi AM, Goldstein RS, Guyatt GH. Interpreting small differences in functional status: The six minute walk test in chronic lung disease patients. Am J Respir Crit Care Med 1997; 155: 1278-1282
    CrossrefPubMedGoogle Scholar
  • 34 Mikus CR, Earnest CP, Blair SN, Church TS. Heart rate and exercise intensity during training: observations from the DREW Study. Br J Sports Med 2009; 43: 750-755
    CrossrefPubMedGoogle Scholar
  • 35 Rowland T, Pober D, Garrison A. Cardiovascular drift in euhydrated prepubertal boys. Appl Physiol Nutr Metab 2008; 33: 690-695
    CrossrefPubMedGoogle Scholar
  • 36 Baillot A, Vibarel-Rebot N, Thomasson R, Jollin L, Amiot V, Emy P, Collomp K. Serum and saliva adrenocortical hormones in obese diabetic men during submaximal exercise. Horm Metab Res 2011; 43: 148-150
    Article in Thieme ConnectPubMedGoogle Scholar
  • 37 Lac G, Lac N, Robert A. International Archives of Physiology, Biochemi­stry and Biophysics. Archs Inter Physiol Biochim Biophys 1993; 101: 257-262
    PubMedGoogle Scholar
  • 38 Weaver JU, Kopelman PG, McLoughlin L, Forsling ML, Grossman A. Hyperactivity of the hypothalamo-pituitary-adrenal axis in obesity: a study of ACTH, AVP, beta-lipotrophin and cortisol responses to insulin-induced hypoglycaemia. Clin Endocrinol (Oxf) 1993; 39: 345-350
    CrossrefPubMedGoogle Scholar
  • 39 Oltmanns KM, Dodt B, Schultes B, Raspe HH, Schweiger U, Born J, Fehm HL, Peters A. Cortisol correlates with metabolic disturbances in a population study of type 2 diabetic patients. Eur J Endocrinol 2006; 154: 325-331
    CrossrefPubMedGoogle Scholar
  • 40 Wong T, Harber V. Lower excess postexercise oxygen consumption and altered growth hormone and cortisol responses to exercise in obese men. J Clin Endocrinol Metab 2006; 91: 678-686
    CrossrefPubMedGoogle Scholar
  • 41 Rask E, Olsson T, Söderberg S, Andrew R, Livingstone DE, Johnson O, Walker BR. Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 2001; 86: 1418-1421
    CrossrefPubMedGoogle Scholar