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The epic Project: Developing National Evidence-based Guidelines for Preventing Healthcare associated Infections

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  • Biotimer assay: A reliable and rapid method for the evaluation of central venous catheter microbial colonization

    2017, Journal of Microbiological Methods
    Citation Excerpt :

    However, CVCs may be colonized on intra- and extra-luminal surfaces by microorganisms in adherent and biofilm lifestyle (Dobbins et al., 2003; Gominet et al., 2017). CVC colonization is correlated to infectious episodes and, in particular, the catheter-related bloodstream infections (CRBSIs) are characterized by high rates of morbidity and mortality (Pratt et al., 2001; Chopra et al., 2013; Gahlot et al., 2014; Yousif et al., 2015). Moreover, the biofilms colonizing CVCs show antimicrobial resistance significantly higher than the planktonic counterparts (Donlan and Costerton, 2002; Hall-Stoodley et al., 2004; Pantanella et al., 2008) prolonging the length of hospitalization and increasing healthcare costs (Kaye et al., 2014; Gahlot et al., 2014).

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Correspondence to: Professor Robert J. Pratt, Director, Richard Wells Research Centre, Wolfson Institute of Health Sciences, Thames Valley University, 32-38 Uxbridge Road, London W5 2BS. Telephone: 44 (0)20 8280 5142. e-mail:[email protected]

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