Elsevier

Journal of Renal Nutrition

Volume 19, Issue 5, September 2009, Pages 365-371
Journal of Renal Nutrition

Original Research
Does Metabolic Syndrome Have an Impact on the Quality of Life and Mood of Hemodialysis Patients?

https://doi.org/10.1053/j.jrn.2009.01.016Get rights and content

Objective

Little is known about the association between metabolic syndrome (MetSyn), health-related quality of life (HRQoL), and depressive symptoms in hemodialysis (HD) patients. We hypothesized that MetSyn may be associated with lower HRQoL and depression in HD patients.

Design

This was a cross-sectional study.

Setting

The trial involved HD patients at a tertiary-care hospital.

Patients

We evaluated 115 patients (41 women and 74 men; mean age, 48.4 ± SD 11.9 years SD).

Methods

MetSyn was defined according to National Cholesterol Education Panel criteria. The Medical Outcomes Study Short Form-36 (SF-36) and Beck Depression Inventory (BDI) were used to assess HRQoL and signs of depression, respectively. We compared HRQoL and clinical and psychosocial characteristics among participants with and without MetSyn.

Results

Fifty patients (43.5%) had MetSyn, and 65 patients (56.5%) were free of MetSyn. Comparisons of SF-36 and BDI scores between HD patients with and without MetSyn revealed no statistically significant differences. The Physical Component Summary Score (PCS) of SF-36 was independently associated with HD duration (β = −0.274, P = .002), age (β = −0.206, P = .024), sleep disturbance (β = −0.175, P = .045), albumin (β = +0.252, P = .006), and hemoglobin (β = +0.270, P = .002) in stepwise linear regression analysis. The MetSyn was not associated with PCS. The Mental Component Summary Score of SF-36 was independently associated with hemoglobin (β = +0.235, P = .016) and BDI score (β = −0.218, P = .025).

Conclusions

The presence of MetSyn was not associated with HRQoL according to the Mental Component Summary Score. In HD patients, HRQoL and depressive behaviors were not influenced by MetSyn, but by various other factors.

Section snippets

Methods

The subjects of this cross-sectional investigation were HD patients at the Dialysis Unit of Baskent University Ankara Hospital (Ankara, Turkey). This study was performed in accordance with the Declaration of Helsinki (http://www.wma.net/e/policy/b3.htm), and written, informed consent was obtained from all patients before enrollment. The dialysis prescription in our study included 4 to 5 hours of HD thrice weekly for all patients with blood flow rates of 300 to 400 mL/min, using a standard

Results

This cross-sectional study consisted of 115 patients (41 women and 74 men; mean age, 48.4 ± 11.9 years; mean HD duration, 112.1 ± 65.4 months). Fifty patients (43.5%) had MetSyn, whereas 65 patients (56.5%) were free of MetSyn. Among these 115 patients, only 7 were living alone. Fifty-three patients were smokers. The educational profile included 59 patients who were illiterate or primary school graduates, and 56 patients who were graduates of secondary school or higher. Eighty-one patients were

Discussion

In contrast to our hypothesis, we found that MetSyn was not related to depressive symptoms (assessed by BDI) and HRQoL (assessed by SF-36). As far as we know, no previous research focused on these issues in HD patients. Therefore, this study is the first to analyze the relationship between MetSyn, depressive symptoms, and HRQoL in this specific patient population.

In patients without renal failure, the relationship between MetSyn, depression, and HRQoL is a matter of somewhat conflicting data.

Conclusion

In HD patients, depressive behaviors and HRQoL are influenced by factors other than MetSyn.

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