REVIEWThe effect of surgical wounding on tumour development
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Cited by (131)
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2021, Journal of Controlled ReleaseCitation Excerpt :Tumor cells can be protected from attacks by establishing immune suppression, a long-considered critical step in both tumor formation and progression. Moreover, surgery leads to numerous factors (inflammation, blood transfusion, anesthetic agents), further consolidating a systemic immunosuppressive state [6,7,13,23]. The immunity is proved to be inhibited under surgical stress that promotes the proliferation of tumor cells, which may last for 6 months after surgery [19].
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2017, Cell ReportsCitation Excerpt :Similarly, high risk of recurrence for early-stage breast cancer patients following mastectomy has been reported in an analysis of 1,173 patients who underwent mastectomy with no subsequent adjuvant systemic therapy (Demicheli et al., 1996). Mechanisms to explain distant metastasis following primary tumor resection include (1) the presence of residual tumor cells or tissue at the resected site (Ando et al., 2003; Minsky et al., 1988), (2) the recruitment of inflammatory cells and platelets to the resected site that promote wound healing and cell proliferation (Ceelen et al., 2014; Hofer et al., 1999; Retsky et al., 2012), and (3) increased local and systemic effects that can induce an angiogenic switch in remote dormant tumors (Bono et al., 2010; Retsky et al., 2012; Takemoto et al., 2012). The seeding of tumor cells at metastatic organ sites is a multistep process.
The effects of surgery-induced immunosuppression and angiogenesis on tumour growth
2015, Veterinary Journal
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Correspondence to: Stefan O. P. Hofer, MD, PhD, Department of Surgery, University Hospital Groningen, PO Box 30.001, NL-9700 RB Groningen, The Netherlands. Fax: NL-50-3614873.