Original articlesMöbius sequence—a Swedish multidiscipline study
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2015, Reproductive ToxicologyCitation Excerpt :Misoprostol is a prostaglandin analog drug commonly prescribed for the prevention and treatment of gastric ulcers and in several countries widely used to induce medical abortions [129]. Möbius sequence is a rare congenital disorder, characterized by uni- or bilateral eye-face palsy due to damage to cranial nerve nuclei, associated with muscle or skeletal malformations in the upper or lower limbs, with an estimated prevalence of 1:50,000 cases in the general population [130,131]. Among the etiological factors responsible for Möbius sequence there are genetic factors, fetal vascular insult and intrauterine exposure to teratogens including misoprostol (during failed abortion attempts with the use of misoprostol) [132,133].
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Correspondence: Kerstin Strömland, Department of Pediatric Ophthalmology, The Queen Silvia Children's Hospital, Sahlgrenska University Hospital/Östra, SE 416 85 Göteborg SWEDEN.e-mail:[email protected]