Original Investigations: Pathogenesis and Treatment of Kidney Disease and HypertensionHealth-related quality of life in Australian adults with renal insufficiency: A population-based study*,**,*
Section snippets
Survey methods
The Australian Diabetes, Obesity and Lifestyle Study (AusDiab) was a nationally representative population-based survey undertaken between May 1999 and December 2000 to determine the prevalence of diabetes mellitus, obesity, and cardiovascular disease risk factors in people 25 years and older. Information on kidney function and indicators of kidney disease also were collected. Details of survey methods have been published elsewhere.8 In short, survey design was based on a stratified cluster
Participants
Of 20,257 eligible people contacted for participation in the AusDiab, 11,247 people (55.3%) attended the physical examination. Information relating to glomerular filtration rate and the SF-36 was available for 10,525 participants (93.6%).
Mean glomerular filtration rate for the population was 85.6 mL/min/1.73 m2 (95% confidence interval, 83.6 to 87.6) and ranged from 9.4 to 193.0 mL/min/1.73 m2. Glomerular filtration rate was less than 60 mL/min/1.73m2 in 11.2% (95% confidence interval, 8.6% to
Discussion
This is the first population-based report that examines effects of renal impairment on health-related quality of life among adults. Moderate renal insufficiency affects both physical and mental components of health-related quality of life, even after accounting for the high burden of associated comorbid disease, indicating that renal insufficiency itself contributes to the observed impairment in health-related quality of life. A differential effect of age is seen, with the largest effect of
Acknowledgements
The authors thank the participants, Survey Team, and Steering Committee of the AusDiab Study.
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Health-Related Quality of Life in People Across the Spectrum of CKD
2020, Kidney International ReportsCitation Excerpt :These socioeconomic measures such as education and marital status may influence life opportunities such as access to health care and the individual’s perception of his or her QoL.35,36 Additionally, we have shown that female sex was associated with worse QOL,18,37,38 reflecting the vulnerability of women with chronic disease as well as their different psychosocial perspective on life (such as experiencing more psychological distress, stigmatization, having family roles that compete for time and resources, and a feeling of disempowerment in their interactions with health professionals) when compared with men.39–41 Although the use of erythropoiesis-stimulating agents was associated with better QoL in CKD stages 3 to 5, it was associated with worse QoL in transplant recipients, suggesting this may be a surrogate for declining allograft function along with the additional burden of needing subcutaneous injections.
Comorbid Depression and Diabetes Are Associated with Impaired Health-Related Quality of Life in Chronic Kidney Disease Patients
2022, Journal of Clinical Medicine
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The Australian Diabetes, Obesity and Lifestyle Study (AusDiab) was supported by the Commonwealth Department of Health and Aged Care; State Governments of Queensland, South Australia, Tasmania, Western Australia, and Victoria; Territory Health Services; the Australian Kidney Foundation; Diabetes Australia (Northern Territory); International Diabetes Institute; Eli Lilly (Australia); Janssen-Cilag (Australia); Knoll Australia; Merck Lipha sa Alphapharm; Merck Sharp & Dohme (Australia); Pharmacia and Upjohn; Roche Diagnostics; Servier Laboratories (Australia); SmithKline Beecham Int; BioRad Laboratories; HITECH Pathology; and Qantas Airways.
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Address reprint request to Esther Briganti, MBBS, MClinEpi, Department of Epidemiology and Preventive Medicine, Central and Eastern Clinical School, Alfred Hospital, Commercial Rd, Prahran 3181, Australia. E-mail: [email protected]
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