Original InvestigationsCross-sectional study of health-related quality of life in African Americans with chronic renal insufficiency: The African American Study of Kidney Sisease and Hypertension Trial*,**,*
Section snippets
Study design
The AASK is a multicenter, randomized, controlled clinical trial using a 2 × 3 factorial design to evaluate the effects of level of blood pressure control and type of antihypertensive medication on progression of chronic renal disease among African American men and women with chronic renal insufficiency caused by hypertension (hypertensive nephrosclerosis).9 Two levels of blood pressure control were defined in terms of mean arterial pressure (MAP = 2/3 diastolic blood pressure + 1/3 systolic
Clinical and demographic characteristics
Selected baseline demographic and clinical characteristics of participants randomized (n = 1,094) onto the AASK trial are listed in Tables 1 and 2.
Characteristic Percent Sex Men 61.2 Women 38.8 Education level Not a high school graduate 40.6 High school graduate 29.8 College or beyond 29.4 Not reported 0.2 Marital status Married/marriage-like relationship 36.0 Divorced/separated 30.9 Never married 20.7
Discussion
This is the first report of HRQL exclusively among African Americans with chronic renal insufficiency clearly attributed to hypertension. Broad-based recruitment efforts10 reviewing more than one half million patient records obtained from various medical settings located throughout the United States provided a patient sample representative of the larger population of African Americans with chronic renal insufficiency. The systematic measurement of clinical and demographic characteristics in
Acknowledgements
The authors appreciate the participation of the men and women on the AASK Trial. Antihypertensive drugs used in the trial were provided by Astra USA; Pfizer, Inc; and King Pharmaceuticals.
References (38)
- et al.
Formal literature review of quality-of-life instruments used in end-stage renal disease
Am J Kidney Dis
(2000) - et al.
Design and baseline characteristics of participants in the African American Study of Kidney Disease and Hypertension (AASK) pilot study
Control Clin Trials
(1996) - et al.
The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads
Am Heart J
(1949) - et al.
Design and statistical issues of the Hemodialysis (HEMO) Study
Control Clin Trials
(2000) - et al.
Monitoring dialysis patients' health status
Am J Kidney Dis
(1994) Psychological factors in adult end-stage renal disease patients treated with hemodialysis: Correlates and outcomes
Am J Kidney Dis
(2000)- et al.
Cross-sectional study of quality of life and symptoms in chronic renal disease patients
Am J Kidney Dis
(1997) - et al.
Responsiveness of the SF-36 among veterans with diabetes
J Diabetes Complications
(2000) - et al.
Clinical correlates of functional status in patients with chronic renal insufficiency
Am J Kidney Dis
(1993) - et al.
Effects of comorbidity on health-related quality-of-life scores: An analysis of clinical trial data
Clin Ther
(1999)
Determinants of socioeconomic differences in change in physical and mental functioning
Soc Sci Med
A comparative review of generic quality-of-life instruments
Pharmacoeconomics
Health status assessment methods for adults: Past accomplishments and future challenge
Annu Rev Public Health
USRDS 1999 Annual Data Report
Relationships of quality-of-life measures to long-term lifestyle and drug treatments in the Treatment of Mild Hypertension Study
Arch Intern Med
Does lowering the blood pressure improve the mood? Quality-of-life results from the Hypertension Optimal Treatment (HOT) study
Blood Press
SF-36 Health Survey
Recruitment in the African American Study of Kidney Disease and Hypertension
J Am Soc Nephrol
Cited by (91)
Disparities in Mental Health and Well-Being Among Black and Latinx Patients With Kidney Disease
2021, Seminars in NephrologyCitation Excerpt :Predictors of HRQOL generally are associated with multidimensional aspects of health and functioning, which may vary by SES. For instance, among a cohort of participants in the American Study of Kidney Disease and Hypertension trial, factors such as employment status, higher income, and higher level of education predicted higher Kidney Disease Quality of Life (KDQOL) physical component summary scores in multivariable analyses.79 Similar factors predicted higher KDQOL mental component summary scores.
Relationship between hypertension with quality of life of hemodialysis patients
2019, Enfermeria ClinicaMetabolic Basis and Pathogenesis of Skeletal Muscle Dysfunction as Cause of Frailty in Chronic Kidney Disease
2023, American Journal of NephrologyASSESSMENT OF DEPRESSION IN HEMODIALYSIS PATIENTS AND ITS IMPACT ON QUALITY OF LIFE
2022, Ain Shams Medical JournalHealth-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey
2022, Kidney and Blood Pressure Research
- *
The AASK trial was supported in part by the Office of Research in Minority Health, The National Institutes of Health; and cooperative agreements no. U01 DK45373, U01 DK45381, U01 DK45386, U01 DK45387, U01 DK45388, U01 DK45426, U01 DK45430, U01 DK48621, U01 DK48643, U01 DK48645, U01 DK48648, U01 DK48652, U01 DK48659, U01 DK48669, U01 DK48677, U01 DK48682, and U01 DK48689 from The National Institute of Diabetes and Digestive and Kidney Diseases.
- **
Address reprint requests to John W. Kusek, PhD, Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Rm 617, 6707 Democracy Blvd, Bethesda, MD 20817. E-mail: [email protected]
- *
0272-6386/02/3903-0008$35.00/0