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Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families

Molecular Psychiatry volume 5, pages 320–322 (2000)Cite this article

Abstract

The role of genetic factors in the etiology of the autistic spectrum of disorders has clearly been demonstrated. Ten chromosomal regions, on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q have potentially been linked to autism.1–8 We have analyzed these chromosomal regions in a total of 17 multiplex families with autism originating from the isolated Finnish population by pairwise linkage analysis and sib-pair analysis. Mild evidence for putative contribution was found only with the 1p chromosomal region in the susceptibility to autism. Our data suggest that additional gene loci exist for autism which will be detectable in and even restricted to the isolated Finnish population.

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References

  1. Risch N, Spiker D, Lotspeich L, Nouri N, Hinds D, Hallmayer J et al. A genomic screen of autism: evidence for a multilocus etiology Am J Hum Genet 1999; 65: 493–507

    Article  CAS  Google Scholar 

  2. International Molecular Genetic Study of Autism Consortium . A full genome screen for autism with evidence for linkage to a region on chromosome 7q Hum Mol Genet 1998; 7: 571–578

    Article  Google Scholar 

  3. Philippe A, Martinez M, Guilloud-Bataille M, Gillberg C, Rastam M, Sponheim et al. Genome-wide scan for autism susceptibility genes Hum Mol Genet 1999; 8: 805–812

    Article  CAS  Google Scholar 

  4. Veenstra-VanderWeele J, Gonen D, Leventhal BL, Cook EH Jr . Mutation screening of the UBE3A/E6-AP gene in autistic disorder Mol Psychiatry 1999; 4: 64–67

    Article  CAS  Google Scholar 

  5. Vieland V . Results of a genomic screen for autism include strong evidence of linkage to chromosome 13 Am J Hum Genet 1998; 63: A16

    Google Scholar 

  6. Klauck SM, Poustka F, Benner A, Lesch KP, Poustka A . Serotonin transporter (5-HTT) gene variants associated with autism? Hum Mol Genet 1997; 6: 2233–2238

    Article  CAS  Google Scholar 

  7. Cook EH Jr, Courchesne R, Lord C, Cox NJ, Yan S, Lincoln A et al. Evidence of linkage between the serotonin transporter and autistic disorder Mol Psychiatry 1997; 2: 247–250

    Article  Google Scholar 

  8. Cook EH Jr, Courchesne RY, Cox NJ, Lord C, Gonen D, Guter SJ et al. Linkage-disequilibrium mapping of autistic disorder, with 15q11–13 markers Am J Hum Genet 1998; 62: 1077–1083

    Article  Google Scholar 

  9. Bailey A, Phillips W, Rutter M . Autism: towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives J Child Psychol Psychiatr Allied Discip 1996; 37: 89–126

    Article  CAS  Google Scholar 

  10. Szatmari P, Jones MB, Zwaigenbaum L, MacLean JE . Genetics of autism: overview and new directions J Autism Dev Disord 1998; 28: 351–368

    Article  CAS  Google Scholar 

  11. Peltonen L, Pekkarinen P, Aaltonen J . Messages from an isolate: lessons from the Finnish gene pool Biol Chem Hoppe Seyler 1995; 376: 697–704

    Article  CAS  Google Scholar 

  12. Vehmanen P, Friedman LS, Eerola H, McClure M, Ward B, Sarantaus L et al. Low proportion of BRCA1 and BRCA2 mutations in Finnish breast cancer families: evidence for additional susceptibility genes Hum Mol Genet 1997; 6: 2309–2315

    Article  CAS  Google Scholar 

  13. Vehmanen P, Friedman LS, Eerola H, Sarantaus L, Pyrhonen S, Ponder BA et al. A low proportion of BRCA2 mutations in Finnish breast cancer families Am J Hum Genet 1997; 60: 1050–1058

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Kuokkanen S, Gschwend M, Rioux JD, Daly MJ, Terwilliger JD, Tienari PJ et al. Genomewide scan of multiple sclerosis in Finnish multiplex families Am J Hum Genet 1997; 61: 1379–1387

    Article  CAS  Google Scholar 

  15. Hovatta I, Varilo T, Suvisaari J, Terwillinger JD, Ollikainen V, Arajärvi R et al. A genomewide scan for schizophrenia genes in an isolated Finnish subpopulation suggesting multiple susceptibility loci Am J Hum Genet 1999; 65: 1114–1124

    Article  CAS  Google Scholar 

  16. Kainulainen K, Perola M, Terwilliger J, Kaprio J, Koskenvuo M, Syvanen AC et al. Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension Hypertension 1999; 33: 844–849

    Article  CAS  Google Scholar 

  17. Pajukanta P, Terwilliger JD, Perola M, Hiekkalinna T, Nuotio I, Ellonen P et al. Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels Am J Hum Genet 1999; 64: 1453–1463

    Article  CAS  Google Scholar 

  18. Ehlers S, Gillberg C . The epidemiology of Asperger syndrome. A total population study J Child Psychol Psychiatr Allied Discip 1993; 34: 1327–1350

    Article  CAS  Google Scholar 

  19. World Health Organization . International Classification of Diseases (10th edn, ch 5). Mental and behavioural disorders. Diagnostic criteria for research WHO: Geneva 1993

    Google Scholar 

  20. Lathrop GM, Lalouel JM . Easy calculations of lod scores and genetic risks on small computers Am J Hum Genet 1984; 36: 460–465

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Lathrop GM, Lalouel JM, White RL . Construction of human linkage maps: likelihood calculations for multilocus linkage analysis Genet Epidemiol 1986; 3: 39–52

    Article  CAS  Google Scholar 

  22. Kuokkanen S, Sundvall M, Terwilliger JD, Tienari PJ, Wikstrom J, Holmdahl R et al. A putative vulnerability locus to multiple sclerosis maps to 5p14–p12 in a region syntenic to the murine locus Eae2 Nat Genet 1996; 13: 477–480

    Article  CAS  Google Scholar 

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Acknowledgements

We thank the families for their participation. We are grateful to Joseph Terwilliger for critical comments on the manuscript. This study was supported by the Academy of Finland and the Foundation for Pediatric Research (Ulla Hjelt Fond).

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Authors and Affiliations

  1. Department of Human Molecular Genetics, National Public Health Institute, Mannerheimintie 166, Helsinki, FIN-00300, Finland

    M Auranen, L Peltonen & I Järvelä

  2. Department of Medical Genetics, University of Helsinki, Helsinki, Finland

    M Auranen, L Peltonen & I Järvelä

  3. Unit of Child Neurology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland

    T Nieminen & R Vanhala

  4. Outpatient Center for Developmental Disorders, Vaalijala Institute, Nenonpelto, Finland

    S Majuri

  5. Department of Human Genetics, UCLA School of Medicine, 33–257 CHS, BOX 851737, Los Angeles, 90095–1737, CA, USA

    L Peltonen

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  1. M Auranen
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  2. T Nieminen
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  3. S Majuri
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  4. R Vanhala
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  5. L Peltonen
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  6. I Järvelä
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Correspondence to M Auranen.

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Auranen, M., Nieminen, T., Majuri, S. et al. Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families. Mol Psychiatry 5, 320–322 (2000). https://doi.org/10.1038/sj.mp.4000708

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  • DOI: https://doi.org/10.1038/sj.mp.4000708

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