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The High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) study: study design and cardiovascular risk factors at the baseline survey

Abstract

In order to establish the methodology of a population strategy for improving cardiovascular risk factors, we have planned the High-risk and Population Strategy for Occupational Health Promotion Study (HIPOP-OHP study). This study is a nonrandomized control trial in approximately 6500 participants in six intervention and six control companies. Our population strategy is based on three factors, nutrition, physical activity, and smoking. For each factor, a researcher's working team was organized and has been supporting the intervention. A standardized method to obtain comparable data has also been established. In the baseline survey, urinary sodium excretion in male subjects was higher, and urinary potassium excretion was lower in both genders in the intervention group compared to the control group. The prevalence of hypertension for both genders was also higher in the intervention group. Male subjects in the intervention group had higher serum total cholesterol than controls, while high-density lipoprotein cholesterol was lower in both genders in the intervention group compared to the control group. These differences were reflected by our finding that the predicted relative risk of coronary heart disease for male subjects was significantly higher in the intervention group (relative risk, RR: 1.17; 95% confidence interval, 95% CI.: 1.09, 1.25) and significantly lower in the control group (RR: 0.93; 95% CI.: 0.89, 0.98) compared to a model Japanese population. Similar results were observed in the female subjects. Taken together, these findings indicate that it is possible to compare trends of predicted relative risk for coronary heart disease between two groups.

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Acknowledgements

This study was funded by research grants from the Ministry of Health and Welfare, Japan (H10-12, No. 063, Research on Health Services, Health Sciences Research Grants, H13, No. 010 Medical Frontier Strategy Research, Health Sciences Research Grants) and from the Ministry of Health, Labor and Welfare, Japan (H14, No. 010 Clinical Research for Evidenced Based Medicine, Health and Labor Sciences Research Grants). We thank Toshimi Yoshida, Department of Health Science, Shiga University of Medical Science, for her excellent clerical support in this research.

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Appendix

Appendix

HIPOP-OHP Research group:

Chairman: Hirotsugu Ueshima (Department of Health Science, Shiga University of Medical Science, Otsu, Shiga).

Participating Researchers: Akira Okayama, Nobuo Nishi, Keiko Tsuji (Department of Hygiene and Public Health, Iwate Medical University, School of Medicine, Iwate), Katsushi Yoshita (Department of National Nutrition Survey and Health Informatics, National Institute of Health and Nutrition), Toru Takebayashi, Yuriko Kikuchi (Department of Preventive Medicine and Public Health, School of Medicine, Keio University), Hideaki Nakagawa, Katsuyuki Miura (Department of Public Health, Kanazawa Medical University), Hiroshi Yamato (Institute of Industrial Ecological Science, University of Occupational and Environmental Health), Nagako Chiba (Department of Human-Life, Tsukuba International Junior College), Masahiko Yanagita (Department of Health and Nutrition, Yonezawa Women's College of Yamagata Prefecture), Kazunori Kodama, Fumiyoshi Kasagi (Department of Epidemiology, Radiation Effects Research Foundation), Yukinori Kusaka (Department of Environmental Health, School of Fukui Medical University), Shigeyuki Saitoh (Second Department of Internal Medicine School of Medicine, Sapporo Medical University), Kiyomi Sakata (Department of Public Health, Wakayama Medical University), Hideo Tanaka (Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases), Masakazu Nakamura (Cholesterol Reference Laboratory Network at Osaka Medical Center for Health Science and Promotion), Masakazu Nakamura, Yoshihiko Naito (Osaka Medical Center for Health Science and Promotion), Yasuyuki Nakamura (Division of Cardiology, Department of Medicine, Shiga University of Medical Science), Makoto Watanabe, Yoshikazu Nakamura (Department of Public Health, Jichi Medical School), Akira Babazono (Institute of Health Science, Kyushu University), Unai Tamura, Junko Minai, Zentaro Yamagata (Department of Health Sciences, School of Medicine, University of Yamanashi), Sumio Urano (Matsushita Health Care Center), Fujihisa Kinoshita (Wakayama Wellness Foundation), Isao Saitoh (Department of Public Health, Nara Medical University), Shinichi Tanihara (Department of Environmental Medicine, Shimane Medical University), Junko Tamaki (Department of Public Health, Hokkaido University Graduate School of Medicine), Osamu Tochikubo (Department of Public Health, Yokohama City University School of Medicine), Takeo Nakayama, Mariko Naito (Department of Medical System Informatics, Graduate School of Medicine and Faculty of Medicine Kyoto University), Shunichi Fukuhara (Department of Epidemiology and Healthcare Research, Graduate School of Medicine and Faculty of Medicine Kyoto University), Yasuharu Fujieda (Department of Health and Sport Sciences, Tokyo Gakugei University), Shunsaku Mizushima (International Research Center for Medical Education, The University of Tokyo), Yuji Miyoshi (Tokyo central Clinic, Health Insurance Society of Meiji Life), Taichiro Tanaka, Takashi Kadowaki, Toshimi Yoshida, Tomonori Okamura (Department of Health Science, Shiga University of Medical Science, Otsu, Shiga).

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Okamura, T., Tanaka, T., Babazono, A. et al. The High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) study: study design and cardiovascular risk factors at the baseline survey. J Hum Hypertens 18, 475–485 (2004). https://doi.org/10.1038/sj.jhh.1001680

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