In a prospective study of adults with Crohn’s disease or ulcerative colitis, Gracie and colleagues have found evidence for the bi-directional relationship between inflammatory bowel disease (IBD) activity and symptoms of psychological disorders. This study represents an important milestone in our understanding of how the brain and gut interact in IBD.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Change of monocytes/macrophages in ulcerative colitis patients with symptoms of anxiety and depression
BMC Gastroenterology Open Access 11 March 2023
-
Symptoms of anxiety/depression is associated with more aggressive inflammatory bowel disease
Scientific Reports Open Access 14 January 2021
-
Self-esteem in patients with inflammatory bowel disease
Quality of Life Research Open Access 06 March 2020
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Mayer, E. A., Bradesi, S., Gupta, A. & Katibian, D. J. in Psychological Aspects of Inflammatory Bowel Disease: A Biopsychosocial Approach (eds Knowles, S. R. & Mikocka-Walus, A.) 20–29 (Routledge, 2014).
Gracie, D. J., Guthrie, E. A., Hamlin, P. J. & Ford, A. C. Bi-directionality of brain-gut interactions in patients with inflammatory bowel diseases. Gastroenterology https://doi.org/10.1053/j.gastro.2018.01.027 (2018).
Koloski, N. A., Jones, M. & Talley, N. J. Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study. Aliment. Pharmacol. Ther. 44, 592–600 (2016).
Mikocka-Walus, A., Knowles, S. R., Keefer, L. & Graff, L. Controversies revisited: a systematic review of the comorbidity of depression and anxiety with inflammatory bowel diseases. Inflamm. Bowel Dis. 22, 752–762 (2016).
Kochar, B. et al. Depression is associated with more aggressive inflammatory bowel disease. Am. J. Gastroenterol. 113, 80–85 (2018).
Click, B. et al. Demographic and clinical predictors of high healthcare use in patients with inflammatory bowel disease. Inflamm. Bowel Dis. 22, 1442–1449 (2016).
Mikocka-Walus, A., Pittet, V., Rossel, J. B., von Kanel, R. & Swiss IBD Cohort Study Group. Symptoms of depression and anxiety are independently associated with clinical recurrence of inflammatory bowel disease. Clin. Gastroenterol. Hepatol. 14, 829–835.e1 (2016).
Gaines, L. S. et al. Association between affective-cognitive symptoms of depression and exacerbation of Crohn’s disease. Am. J. Gastroenterol. 111, 864–870 (2016).
Knowles, S., Andrews, J. M. & Porter, A. Predictors of impaired mental health and support seeking in adults with inflammatory bowel disease: an online survey. Gastroenterol. Nurs. 41, 38–46 (2018).
Gracie, D. J. et al. Effect of psychological therapy on disease activity, psychological comorbidity, and quality of life in inflammatory bowel disease: a systematic review and meta-analysis. Lancet Gastroenterol. Hepatol. 2, 189–199 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
A.M.-W. has previously collaborated with D. Gracie, P. Hamlin and A. Ford on the study of the role of psychotherapy in IBD.
Rights and permissions
About this article
Cite this article
Mikocka-Walus, A., Andrews, J.M. It is high time to examine the psyche while treating IBD. Nat Rev Gastroenterol Hepatol 15, 329–330 (2018). https://doi.org/10.1038/s41575-018-0004-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41575-018-0004-y
This article is cited by
-
Change of monocytes/macrophages in ulcerative colitis patients with symptoms of anxiety and depression
BMC Gastroenterology (2023)
-
Symptoms of anxiety/depression is associated with more aggressive inflammatory bowel disease
Scientific Reports (2021)
-
Self-esteem in patients with inflammatory bowel disease
Quality of Life Research (2020)