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Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Bone Marrow Transplantation volume 55, pages 1126–1136 (2020)Cite this article

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A Correction to this article was published on 20 February 2020

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Abstract

Hematopoietic stem cell transplantation (HSCT) is currently the standard of care for many malignant and nonmalignant blood diseases. As several treatment-emerging acute toxicities are expected, optimal supportive measurements critically affect HSCT outcomes. The paucity of good clinical studies in supportive practices gives rise to the establishment of heterogeneous guidelines across the different centers, which hampers direct clinical comparison in multicentric studies. Aiming to harmonize the supportive care provided during the pediatric HSCT in Europe, the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) promoted dedicated workshops during the years 2017 and 2018. The present paper describes the resulting consensus on the management of sinusoidal obstructive syndrome, mucositis, enteral and parenteral nutrition, iron overload, and emesis during HSCT.

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Fig. 1: Decisional tree for the composition of the triple antiemetic prophylaxis in high emetogenic conditioning regimens.

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Article 19 May 2021

Raheel Iftikhar, Parvez Ahmad, … Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation (SAAWP of EBMT)

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Author information

Authors and Affiliations

  1. Division of Pediatric Hematology-Oncology, University Hospital of Geneva, Geneva, Switzerland

    Tiago Nava & Marc Ansari

  2. Hematology and Immunology Department, Robert-Debre Hospital, Assistance Publique—Hopitaux de Paris & University of Paris, Paris, France

    Jean-Hugues Dalle

  3. Department of Pediatric Oncology and Hematology, Hospital Universitari Vall d’Hebron, Barcelona, Spain

    Christina Diaz de Heredia

  4. Department of Hematology, Immunology, Oncology and Stem Cell Transplantation, University Children’s Hospital Zürich, Zürich, Switzerland

    Tayfun Güngör

  5. Paediatric Transplant Unit, Hospital University and Polytechnic Hospital LA FE, Valencia, Spain

    Eugenia Trigoso

  6. SCT-Unit, St. Anna Children’s Hospital, Medical University Vienna, Vienna, Austria

    Ulrike Falkenberg, Anita Lawitschka & Christina Peters

  7. Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, IRCCS, Ospedale Bambino Gesù, Rome, Italy

    Alice Bertaina

  8. Department of Paediatric Haematology–Oncology, Royal Hospital for Children, Glasgow, Scotland, UK

    Brenda Gibson

  9. Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany

    Andrea Jarisch, Shahrzad Bakhtiar, Andre Willasch & Peter Bader

  10. Clinica Pediatrica Università degli Studi di Milano Bicocca, Fondazione MBBM, Ospedale San Gerardo, Monza, Italy

    Adriana Balduzzi

  11. Institute for Transfusion Medicine and Immunohematology of Goethe University and German Red Cross Blood Service Baden-Württemberg-Hessen, Frankfurt/Main, Germany

    Halvard Boenig

  12. Central Hospital of Southern Pest, National Institute of Hematology and Infectious Disease, Budapest, Hungary

    Gergely Krivan

  13. Children’s Hospital, and Pediatric Research Center, University of Helsinki, Helsinki, Finland

    Kim Vettenranta

  14. Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia

    Toni Matic

  15. Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway

    Jochen Buechner

  16. Department of Pediatric Hematology, Oncology and BMT, Wroclaw Medical University, Wroclaw, Poland

    Krzysztof Kalwak

  17. Department of Pediatric Hematology & Pediatric Stem Cell Transplantation Unit, Antalya & Goztepe Medicalpark Hospitals, Antalya, Turkey

    Akif Yesilipek

  18. Department of BMT, Great Ormond Street Hospital for Children, National Health Service (NHS) Foundation Trust, London, UK

    Giovanna Lucchini

  19. Division of Molecular Hematology, Lund University, Lund, Sweden

    Dominik Turkiewicz

  20. Department of Pediatrics, Oulu University Hospital, Oulu, Finland

    Riitta Niinimäki

  21. Division of Pediatric Hematology/Oncology, University Children’s Hospital of Basel, Basel, Switzerland

    Tamara Diesch

  22. Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany

    Thomas Lehrnbecher

  23. Division of Pediatric Hematology and Oncology, Hospital Motol, Charles University, Prague, Czech Republic

    Petr Sedlacek

  24. Division of Pediatric Hematology, Oncology and BMT, The Edmond and Lily Safra Children’s Hospital, Tel Hashomer, Israel

    Daphna Hutt

  25. EBMT Paris Office, Hôpital Saint Antoine, Paris, France

    Arnaud Dalissier

  26. Department of Pediatric Oncology, Hematology and HSCT, Poznan University of Medical Sciences, Poznań, Poland

    Jacek Wachowiak

  27. Division of Pediatric Hematoloy/Oncology, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel

    Isaac Yaniv & Jerry Stein

  28. Department of Pediatric Bone Marrow Transplantation Unit, MedicalPark Göztepe Hospital, Instanbul, Turkey

    Koray Yalçin

  29. Pediatric Hematology, Oncology and HSCT Unit, Hospital Santa Creu i Sant Pau, Barcelona, Spain

    Luisa Sisinni

  30. Paediatric Haematology/Oncology Department, IRCCS G Gaslini, Genova, Italy

    Marco Deiana

  31. Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

    Marianne Ifversen

  32. Heinrich Heine University Dusseldorf, Dusseldorf, Germany

    Michaela Kuhlen

  33. Division of Pediatric Stem Cell Therapy, Clinic for Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany

    Roland Meisel

  34. Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy

    Simone Cesaro

  35. Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital of Regensburg, Regensburg, Germany

    Selim Corbacioglu

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  1. Tiago Nava
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  2. Marc Ansari
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  34. Marco Deiana
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  37. Roland Meisel
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  39. Simone Cesaro
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  40. Andre Willasch
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  42. Peter Bader
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Correspondence to Peter Bader.

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Nava, T., Ansari, M., Dalle, JH. et al. Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 55, 1126–1136 (2020). https://doi.org/10.1038/s41409-020-0818-4

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