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Bone

Exploring factors responsible for bone formation in DISH

Nature Reviews Rheumatology volume 8, pages 10–12 (2012)Cite this article

Lessons from the study of other rheumatic diseases are improving our understanding of diffuse idiopathic skeletal hyperostosis (DISH). New data implicate Dickkopf-1 in the evolution of the most severe manifestations of the condition. Nevertheless, real insights into the pathogenesis—and treatments that might result from them—are still lacking.

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Figure 1: Typical radiographic appearance of DISH.

References

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Authors and Affiliations

  1. Rheumatic Diseases Unit, Ha'Emek Medical Center, Rabin Road, 18101, Afula, Israel

    Reuven Mader

  2. Department of Orthopedics, University Medical Center Utrecht, PO Box 85500, Utrecht, 3508 GA, The Netherlands

    Jorrit-Jan Verlaan

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  1. Reuven Mader
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  2. Jorrit-Jan Verlaan
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Correspondence to Reuven Mader.

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The authors declare no competing financial interests.

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Mader, R., Verlaan, JJ. Exploring factors responsible for bone formation in DISH. Nat Rev Rheumatol 8, 10–12 (2012). https://doi.org/10.1038/nrrheum.2011.189

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