Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Movement disorders

Why movement and cognition belong together

The largest ever study of cognitive function in progressive supranuclear palsy and multiple system atrophy, investigating almost 700 patients, confirms that cognitive dysfunction in these conditions is common and often severe, and can occur early in the course of the disease. Detection, however, depends on an appropriate choice of tests.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Steele, J. C., Richardson, J. C. & Olszewski, J. Progressive supranuclear palsy. A heterogeneous degeneration involving the brainstem, basal ganglia and cerebellum with vertical supranuclear gaze and pseudobulbar palsy, nuchal dystonia and dementia. Arch. Neurol. 10, 333–359 (1964).

    Article  CAS  Google Scholar 

  2. Pillon, B., Dubois, B., Ploska, A. & Agid, Y. Severity and specificity of cognitive impairment in Alzheimer's, Huntington's, and Parkinson's disease and progressive supranuclear palsy. Neurology 41, 634–643 (1991).

    Article  CAS  Google Scholar 

  3. Bak, T. H., Crawford, L. M., Hearn, V. C., Mathuranath, P. S. & Hodges, J. H. Subcortical dementia revisited: similarities and differences in cognitive function between progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA). Neurocase 11, 268–273 (2005).

    Article  CAS  Google Scholar 

  4. Brown, R. G. et al. Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy. Brain 133, 2382–2393 (2010).

    Article  Google Scholar 

  5. Bak, T. H. et al. Cognitive bedside assessment in atypical parkinsonian syndromes. J. Neurol. Neurosurg. Psychiatry 76, 420–422 (2005).

    Article  CAS  Google Scholar 

  6. Williams, D. R. et al. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain 130, 1566–1576 (2007).

    Article  Google Scholar 

  7. Ghosh, B., Rowe, J., Calder, A., Hodges, J. R. & Bak, T. H. Emotion recognition in progressive supranuclear palsy. J. Neurol. Neurosurg. Psychiatry 80, 1143–1145 (2009).

    Article  CAS  Google Scholar 

  8. Josephs, K. A. et al. Atypical progressive supranuclear palsy underlying progressive apraxia of speech and nonfluent aphasia. Neurocase 11, 283–296 (2005).

    Article  CAS  Google Scholar 

  9. Bak, T. H., Caine, D., Hearn, V. C. & Hodges, J. R. Visuospatial functions in atypical parkinsonian syndromes J. Neurol. Neurosurg. Psychiatry 77, 454–456 (2006).

    Article  CAS  Google Scholar 

  10. Middleton, F. A. & Strick, P. L. Basal ganglia and cerebellar loops: motor and cognitive circuits. Brain Res. Brain Res. Rev. 31, 236–250 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bak, T. Why movement and cognition belong together. Nat Rev Neurol 7, 10–12 (2011). https://doi.org/10.1038/nrneurol.2010.177

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2010.177

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing