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'Macrophage' cannabinoid receptor goes up in smoke

CB2 receptors, expressed mainly by immune cells in the periphery, are thought to be minimally involved in cannabinoid signaling in brain. However, a study now finds that brain CB2 receptors may be central to cocaine addiction.

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Figure 1: Possible mechanisms by which CB2 receptors may regulate accumbal dopamine levels.

References

  1. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., Young, A.C. & Bonner, T.I. Nature 346, 561–564 (1990).

    Article  CAS  Google Scholar 

  2. Herkenham, M. et al. J. Neurosci. 11, 563–583 (1991).

    Article  CAS  Google Scholar 

  3. Munro, S., Thomas, K.L. & Abu-Shaar, M. Nature 365, 61–65 (1993).

    Article  CAS  Google Scholar 

  4. Griffin, G. et al. Eur. J. Pharmacol. 377, 117–125 (1999).

    Article  CAS  Google Scholar 

  5. Chin, C.L. et al. Br. J. Pharmacol. 153, 367–379 (2008).

    Article  CAS  Google Scholar 

  6. Cabral, G.A., Raborn, E.S., Griffin, L., Dennis, J. & Marciano-Cabral, F. Br. J. Pharmacol. 153, 240–251 (2008).

    Article  CAS  Google Scholar 

  7. Xi, Z.-X. et al. Nat. Neurosci. 14, 1160–1166 (2011).

    Article  CAS  Google Scholar 

  8. Onaivi, E.S. et al. Ann. NY Acad. Sci. 1074, 514–536 (2006).

    Article  CAS  Google Scholar 

  9. Van Sickle, M.D. et al. Science 310, 329–332 (2005).

    Article  CAS  Google Scholar 

  10. Ishiguro, H. et al. Biol. Psychiatry 67, 974–982 (2010).

    Article  CAS  Google Scholar 

  11. Ishiguro, H. et al. Pharmacogenomics J. 7, 380–385 (2007).

    Article  CAS  Google Scholar 

  12. Xi, Z.-X., et al. Neuropsychopharmacology 33, 1735–1745 (2008).

    Article  CAS  Google Scholar 

  13. Pertwee, R.G. et al. Pharmacol. Rev. 62, 588–631 (2010).

    Article  CAS  Google Scholar 

  14. Suzuki, A. et al. Cell 144, 810–823 (2011).

    Article  CAS  Google Scholar 

  15. Russo, S.J. et al. J. Neurosci. 29, 3529–3537 (2009).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Paul J Kenny.

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Kenny, P. 'Macrophage' cannabinoid receptor goes up in smoke. Nat Neurosci 14, 1100–1102 (2011). https://doi.org/10.1038/nn.2912

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