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Microsaccadic eye movements and firing of single cells in the striate cortex of macaque monkeys

Nature Neuroscience volume 3, pages 251–258 (2000)Cite this article

An Erratum to this article was published on 01 April 2000

An Erratum to this article was published on 01 April 2000

Abstract

When viewing a stationary object, we unconsciously make small, involuntary eye movements or ‘microsaccades’. If displacements of the retinal image are prevented, the image quickly fades from perception. To understand how microsaccades sustain perception, we studied their relationship to the firing of cells in primary visual cortex (V1). We tracked eye movements and recorded from V1 cells as macaque monkeys fixated. When an optimally oriented line was centered over a cell's receptive field, activity increased after microsaccades. Moreover, microsaccades were better correlated with bursts of spikes than with either single spikes or instantaneous firing rate. These findings may help explain maintenance of perception during normal visual fixation.

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Figure 1: Responses of a cell located within the operculum of striate cortex to a white 8° circle.
Figure 2: Spikes and eye positions recorded during several two-second trials from two monkeys.
Figure 3: Correlation between microsaccades and spikes.
Figure 4: Instantaneous firing-rate analysis.
Figure 5: Burst analysis.
Figure 6: (a) Peak probability that a microsaccade occurred before bursts, as a function of burst size, for all latencies and ISIs.
Figure 7: Peak probability that a spike was preceded by a microsaccade for each cell.
Figure 8: Distribution of burst sizes yielding peak probabilities across the population of cells.
Figure 9: The main sequence analysis.

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Notes

  1. Editorial correction The printed version of this article contained an error introduced during editing. References 24-27 (below24,25,26,27) were omitted. We regret the error.

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Acknowledgements

We thank Gail Robertson, David Freeman, Michael Lafratta and Frederic Russo for technical assistance and Margaret Livingstone, Clay Reid, Richard Born and Max Snodderly for reading the manuscript and making comments. We also thank Murray Sherman, Jonathan Victor, John Maunsell and Guy Orban for their advice on the analysis and design of the project. This work was supported by research (to D.H.H.) and training grants (to S.L.M.) from the National Eye Institute. S.M.-C. is a fellow from the MEC-FPI program (Spain).

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  1. Dept. of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, 02115, Massachusetts, USA

    Susana Martinez-Conde, Stephen L. Macknik & David H. Hubel

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  1. Susana Martinez-Conde
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Correspondence to Susana Martinez-Conde.

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Martinez-Conde, S., Macknik, S. & Hubel, D. Microsaccadic eye movements and firing of single cells in the striate cortex of macaque monkeys. Nat Neurosci 3, 251–258 (2000). https://doi.org/10.1038/72961

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