Abstract
HUMAN periodontal diseases are the major cause of adult tooth loss. One such disease, localised idiopathic juvenile periodontitis (IJP) affects young people and is unusually severe, with a rapid progression. Previous studies have shed little light on the unusual susceptibility of some patients to this rare condition. Similarly, destructive periodontal syndromes have been described in patients with polymorphonuclear leukocyte (PMNL) dysfunction. We have measured two parameters of neutrophil function, chemotaxis and phagocytosis, and found that patients with IJP have significantly decreased PMNL function compared with healthy control subjects, but monocyte function remains unaffected in IJP. Reduced PMNL functions may contribute to the unusual susceptibility of patients to IJP.
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CIANCIOLA, L., GENCO, R., PATTERS, M. et al. Defective polymorphonuclear leukocyte function in a human periodontal disease. Nature 265, 445–447 (1977). https://doi.org/10.1038/265445a0
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DOI: https://doi.org/10.1038/265445a0
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