Abstract
Diploid human fibroblasts accumulate heat labile enzymes during the final stages of their life-span in culture. The RNA base analogue 5-FU induces premature senescence, which is preceded by the appearance of altered enzyme. These observations support Orgel's “error catastrophe” theory of ageing.
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HOLLIDAY, R., TARRANT, G. Altered Enzymes in Ageing Human Fibroblasts. Nature 238, 26–30 (1972). https://doi.org/10.1038/238026a0
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DOI: https://doi.org/10.1038/238026a0
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