Abstract
In this research note, DeFries-Fulker (DF) regression analysis is reframed in model-fitting terms, where an individual's expected score is modeled as a function of their co-twin's proband status. This more flexible implementation of the DF model allows DZ-O twins to be incorporated in a sex-limitation model. Brief simulation results are presented along with the Mx scripts used.
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References
DeFries, J. C., and Fulker, D. W. (1985). Multiple regression analysis of twin data. Behav. Genet. 15(5): 467-473.
DeFries, J. C., and Fulker, D. W. (1988). Multiple regression analysis of twin data: Etiology of deviant scores versus individual differences. Acta Genet. Med. Gemellol. 37: 205-216.
Kohler, H. P., and Rodgers, J. L. (2001). DF-analyses of heritability with double-entry twin data: Asymptotic standard errors and efficient estimation. Behav. Genet. 31(2): 179-191.
Purcell, S., Eley, T. C., Dale, P. S., Oliver, B., Petrill, S. A., Price, T. S., Saudino, K. J., Simonoff, E., Stevenson, J., Taylor, E., and Plomin, R. (2001). Comorbidity between verbal and nonverbal cognitive delays in 2-year-olds: A bivariate twin analysis. Dev. Sci. 4: 195-208.
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Purcell, S., Sham, P.C. A Model-Fitting Implementation of the DeFries-Fulker Model for Selected Twin Data. Behav Genet 33, 271–278 (2003). https://doi.org/10.1023/A:1023494408079
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DOI: https://doi.org/10.1023/A:1023494408079