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Determinants for Lentiviral Infection of Non-Dividing Cells

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Somatic Cell and Molecular Genetics

Abstract

Lentiviruses share the common characteristic of infecting non-dividing target cells, distinguishing them from the oncogenic retroviruses which only productively infect dividing cells. The search for determinants for infection of non-dividing cells has produced a number of candidates. From HIV-1, the viral proteins matrix, integrase and Vpr have all been implicated. A structural determinant, the central DNA flap, has also been implicated. The supporting evidence for each of these proposed determinants will be examined and compared to how other viruses, non-retroviruses, transport their genomes to the nucleus. With currently available data, integrase and the central DNA flap appear to be the key players, and yet the mechanism for infection of non-dividing cells remains undefined.

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  1. Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109

    Marie A. Vodicka

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Vodicka, M.A. Determinants for Lentiviral Infection of Non-Dividing Cells. Somat Cell Mol Genet 26, 35–49 (2001). https://doi.org/10.1023/A:1021022629126

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