Abstract
The purpose of this study was to assess the effect of rabeprazole 20 mg once a day on patient-reported health-related quality of life in routine clinical practice. Patients with erosive gastroesophageal reflux disease participating in an open-label, 8-week study completed the SF-36 Health Survey before and after treatment with rabeprazole. For all SF-36 scales, there was a statistically significant (p ≤ 0.007) improvement in mean scores from baseline to week 8. Improvements in each of the subscales, except for physical functioning, general health, and mental health, were at least 5% in magnitude, a level considered clinically meaningful. Furthermore, while baseline scores were significantly poorer than general United States population scores, follow-up scores for four of the subscales (role limitations due to physical problems, social functioning, role limitations due to emotional problems, and mental health) were comparable to general population scores. In conclusion, rabeprazole significantly improved health-related quality of life in erosive gastroesophageal reflux disease patients and restored social functioning and emotional well-being to levels comparable to those observed in the United States general population.
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REFERENCES
Revicki DA, Wood M, Maton PN, Sorensen S: The impact of gastroesophageal reflux disease on health-related quality of life. Am J Med 104:252–258, 1998
Havelund T, Lind T, Wiklund I, Glise H, Hernqvist H, Lauritsen K, Lundel L, Pedersen SA, Carlsson R, Junghard O, Stubberod A, Anker-Hansen O: Quality of life in patients with heartburn but without esophagitis: effects of treatment with omeprazole. Am J Gastroenterol 94:1782–1789, 1999
Kapla-Machlis B, Spiegler GE, Revicki DA: Health-related quality of life in primary care patients with gastroesophageal reflux disease. Ann Pharmacother 33:1032–1036, 1999
Farup C, Kleinman L, Sloan S, Ganoczy D, Chee E, Lee C, Revicki D: The impact of nocturnal symptoms associated with gastroesophageal reflux disease on health-related quality of life. Arch Intern Med 161:45–52, 2001
Revicki DA, Crawley JA, Zodet MW, Levine DS, Joelsson BO: Complete resolution of heartburn symptoms and healthrelated quality of life in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 13:1621–1630, 1999
Cloud ML, Enas N, Humphries TJ, Bassion S. The Rabeprazole Study Group: Rabeprazole in treatment of acid peptic diseases: results of three placebo-controlled doseresponse clinical trials in duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease (GERD). Dig Dis Sci 43:993–1000, 1998
Johnson D, Perdomo C, Barth J, Jokubaitis L: The benefit/risk profile of rabeprazole, a new proton-pump inhibitor. Eur J Gastroenterol Hepatol 2:799–806, 2000
Robinson M, Fitzgerald A, Hegedus R, Murthy A, Jokubaitis L: Onset of symptom relief with rabeprazole: a communitybased open-label assessment of patients with erosive esophagitis. Aliment Pharmacol Ther 16:445–454, 2002
Ware JE, Snow KK, Kosinski M: SF-36 Health Survey Manual and Interpretation Guide. Boston. The Health Institute, New England Medical Center, 1993
Ware JE, Kosinski M, Keller SD: SF-36 Physical and Mental Health Summary Scales: A User's Manual. Boston. The Health Institute. New England Medical Center, 1994
Chal KL, Stacey JH, Sacks GE: The effect of ranitidine on symptom relief and quality of life of patients with gastrooesophageal reflux disease. Br J Clin Pract 49:73–77, 1995
Rush DR, Stelmach WJ, Young TL, Kirchdoerfer LJ, Scott-Lennox J, Holverson HE, Sabesin SM, Nicholas TA: Clinical effectiveness and quality of life with ranitidine vs placebo in gastroesophageal reflux disease patients: a clinical experience network (CEN) study. J Fam Pract 41:126–136, 1995
Mathias SD, Castell DO, Elkin EP, Matosian ML: Healthrelated quality of life of patients with acute erosive reflux esophagitis. Dig Dis Sci 41:2123–2129, 1996
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Johanson, J.F., Siddique, R., Damiano, A.M. et al. Rabeprazole Improves Health-Related Quality of Life in Patients with Erosive Gastroesophageal Reflux Disease. Dig Dis Sci 47, 2574–2578 (2002). https://doi.org/10.1023/A:1020532714664
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DOI: https://doi.org/10.1023/A:1020532714664