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Generators of Visual Evoked Potentials for Faces and Eyes in the Human Brain as Determined by Dipole Localization

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Abstract

Human visual evoked potentials were recorded during presentation of photos of human and animal faces and various face features. Negative waves with approximate peak latencies of 165 msec (N170) were bilaterally recorded from the occipito-temporal regions. Mean peak latencies of the N170 were shorter for faces than eyes only. Analyses of amplitudes of evoked potentials indicated that the N170 elicited by faces reflected activity of a specific neural system which was insensitive to detailed differences among individual faces regardless of species, and consequently suggest that this system might function to detect existence of faces in general. On the other hand, the mean amplitude of the N170 elicited by human eyes was significantly larger than those by animal eyes. These differences in response latencies and amplitudes of the N170 suggest existence of at least 2 different visual evoked potentials with similar latencies (i.e., N170) which are sensitive to faces in general and human eyes, respectively. Dipole source localization analysis indicated that dipoles for the N170 elicited by eyes were located in the posterior inferior temporal gyrus, and those for faces, located initially in the same region, but moved toward the fusiform and lingual gyri at the late phase of the N170. The results indicated that information processing of faces and eyes separated at least as early as the latency of the N170 at the posterior inferior temporal gyrus as well as the fusiform and lingual gyri, and might provide neurophysiological and anatomical bases to an initial structural encoding stage of human faces.

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References

  • Allison, T., Ginter, H., McCarthy, G., Nobre, A.C., Puce, A., Luby, M. and Spencer, D.D. Face recognition in human extrastriate cortex. J. Neurophysiol., 1994a, 71: 821–825.

    Google Scholar 

  • Allison, T., McCarthy, G., Nobre, A.C., Puce, A. and Belger, A. Human extrastriate visual cortex and the perception of faces, words, numbers,andcolors. Cereb. Cortex, 1994b, 5: 544–554.

    Google Scholar 

  • Allison, T., Puce, A., Spencer, D.D. and McCarthy, G. Electrophysiological Studies of Human Face Perception. I: Potentials generated in occipitotemporal cortex by face and non-face stimuli. Cereb. Cortex, 1999, 9: 415–430.

    Google Scholar 

  • Bentin, S., Allison, T., Puce, A., Perez, E. and McCarthy, G. Electrophysiological studies of face. Perception in humans. J. Cognit. Neurosci., 1996, 8: 551–565.

    Google Scholar 

  • Bötzel, K., Schulze, S. and Stodieck, S.R. Scalp topography and analysis of intracranial sources of face-evoked potentials. Exp. Brain Res., 1995, 104: 135–143.

    Google Scholar 

  • Bruce, V. and Young, A. Understanding face recognition. Br. J. Psychol., 1986, 77: 305–327.

    Google Scholar 

  • Clark, V.P., Keil, K., Maisog, J.M., Courtney, S.M., Ungerleider, L.G. and Haxby, J.V. Functional magnetic resonance imaging of human visual cortex during face matching: a comparison with positron emission tomography. Neuroimage, 1996, 4: 1–15.

    Google Scholar 

  • Clarke, S., Lindemann, A., Maeder, P., Borruat, F.-X. and Assal, G. Face recognition and postero-inferior hemispheric lesions. Neuropsychologia, 1997, 35: 1555–1563.

    Google Scholar 

  • DeRenzi, E. Prosopagnosia in two patients with CTscan evidence of damage to the right hemisphere. Neuropsychology, 1986, 24: 385–389.

    Google Scholar 

  • Eifuku, S., De Souza, W.C., Nishijo, H., Tamura, R. and Ono, T. Neuronal activity of monkey anterior temporal cortex including perirhinal cortex and area STPa during face identification. Soc. Neurosci. Abstr., 1999, 25:916.

    Google Scholar 

  • Eimer, M. Does the face-specific N170 component reflect the activity of a specialized eye processor? Neuroreport, 1998, 9: 2945–2948.

    Google Scholar 

  • Eimer, M. and McCarthy, R.A. Prosopagnosia and structural encoding of faces: Evidence from event-related potentials. Neuroreport, 1999, 10: 253–259.

    Google Scholar 

  • Eimer, M. Event-related brain potentials distinguish processing stages involved in face perveption and recognition. Clin. Neurophysiol., 2000, 111: 694–705.

    Google Scholar 

  • Fraser, I. and Paker, D. Reaction time measures of feature saliency in a perceptual integration task. Aspects of face processing, 1986: 45–52.

  • George, N., Evans, J., Fiori, N., Davidoff, J. and Renault, B. Brain events related to normal and moderately scrambled faces. Cogn. Brain. Res., 1996, 4: 65–76.

    Google Scholar 

  • Halgren, E., Raij, T., Marinkovic, K., Jousmäki, V. and Hari, R. Cognitive response profile of the human fusiform face area as determined by MEG. Cereb. Cortex, 2000, 10: 69–81.

    Google Scholar 

  • Hasselmo, M.E., Rolls, E.T., Baylis, G.C. and Nalwa, V. Object-centered encoding by face-selective neurons in the cortex in the superior temporal sulcus of the monkey. Exp. Brain Res., 1989, 75: 417–429.

    Google Scholar 

  • Hayashi, N., Nishijo, H., Ono, T., Endo, S. and Tabuchi, E. Generators of somatosensory evoked potentials investigated by dipole tracing in the monkey. Neuroscience, 1995, 68: 323–338.

    Google Scholar 

  • Haxby, J.V., Horwitz, B., Ungerleider, L.G., Maisog, J.M., Pietrini, P. and Grady, C.L. The functional organization of human extrastriate cortex: a PET-rCBF study of selective attention to faces and locations. J. Neurosci., 1994, 14: 6336–6353.

    Google Scholar 

  • Haxby, J.V., Ungerleider, L.G., Horwitz, B., Rapoport, S.I. and Grady, C.L. Hemispheric differences in neural systems for face working memory: a PET-rCBF study. Hum. Brain Mapp., 1995, 3: 68–82.

    Google Scholar 

  • He, B., Musha, T., Okamoto, Y. and Homma, S. Electric dipole tracing in the human brain by means of the boundary element method and its accuracy. IEEE. Trans. Biomed. Eng., 1987, 34: 406–414.

    Google Scholar 

  • Homma, S., Musha, T., Nakajima, Y., Okamoto, Y., Blom, S., Flink, R., Hagbarth, K.E. and Mostrom, U. Localization of electric current sources in the human brain estimated by the dipole tracing method of the scalp-skull-brain (SSB) head model. Electroencephalor. Clin. Neurophysiol., 1994, 91: 374–382.

    Google Scholar 

  • Ishai, A., Ungerleider, L.G., Martin, A. and Haxby, J.V. The representation of objects in the human occipital and temporal cortex. J. Cog. Neurosci., 2000, 12 (Suppl. 2): 35–51.

    Google Scholar 

  • Ikeda, H., Nishijo, H., Miyamoto, K., Tamura, R., Endo, S. and Ono, T. Generators of visual evoked potentials investigated by dipole tracing in the human occipital cortex. Neuroscience, 1998, 84: 723–739.

    Google Scholar 

  • Jemel, B., George, N., Chaby, L., Fiori, N. and Renault, B. Differential processing of part-to-whole and part-to-part face priming: anERPstudy. Neuroreport, 1999, 10: 1069–1075.

    Google Scholar 

  • Kanwisher, N., McDermott, J. and Chun, M.M. The fusiform face area: a module in human extrastriate cortex specialized for face perception. J. Neurosci., 1997, 17: 4302–4311.

    Google Scholar 

  • Kanwisher, N., Stanley, D. and Harris, A. The fusiform face area is selective for faces not animals. Neuroreport, 1999, 10: 183–187.

    Google Scholar 

  • McCarthy, R.A. and Warrington, E.K. Visual associative agnosia: a clinico-anatomical study of a single case. J. Neurol. Neurosurg. Psychiat., 1986, 49: 1233–1240.

    Google Scholar 

  • McCarthy, G., Puce, A., Belger, A. and Allison, T. Electrophysiological studies of human face perception.II: Response of properties of face-specific potentials generated in occipitotemporal cortex. Cereb. Cortex, 1999, 9: 431–444.

    Google Scholar 

  • Musha, T. and Homma, S. Do optimal dipoles obtained by the dipole tracing method always suggest true source locations? Brain Topogr., 1990, 3: 143–150.

    Google Scholar 

  • Nishijo, H., Hayashi, N., Fukuda, M. and Ono, T. Localization of dipole by boundary element method in three-dimensional reconstructed monkey brain. Brain Res. Bull., 1994, 33: 225–230.

    Google Scholar 

  • Nishijo, H., Ikeda, H., Miyamoto, K., Endo, S. and Ono, T. Localization of an ictal onset zone using a realistic 4-shell head model of scalp, skull, liquor, and brain. Soc. Neurosci. Abstr., 1996, 22: 185.

    Google Scholar 

  • Perrett, D.I, Heitanen, J.K, Oram, M.W. and Benson, P.J. Organization and functions of cells responsive to faces in the temporal cortex. Philos. Trans. R. Soc. Lond. B., 1992, 335: 23–30.

    Google Scholar 

  • Perrett, D.I. and Oram, M.W. Visual recognition based on temporal cortex cells: viewer-centered processing of pattern configuration. Z. Naturforsch. [C], 1998, 53: 518–541.

    Google Scholar 

  • Perrett, D.I., Rolls, E.T. and Caan, W. Visual neurons responsive to faces in the monkey temporal cortex. Exp. Brain Res., 1982, 47: 329–342.

    Google Scholar 

  • Rolls, E.T. Neurophysiological mechanisms underlying face processing within and beyond the temporal cortical visual areas. Philos. Trans. R. Soc. Lond. B., 1992, 335: 11–20.

    Google Scholar 

  • Rolls, E.T. Functions of the primate temporal lobe cortical visual areas in invariant visual object and face recognition. Neuron, 2000, 27: 1–20.

    Google Scholar 

  • Puce, A., Allison, T., Gore, J.C. and McCarthy, G. Face-sensitive regions in human extrastriate cortex studied by functional MRI. J. Neurophysiol., 1995, 74: 1192–1199.

    Google Scholar 

  • Puce, A., Allison, T., Bentin, S., Gore, J.C. and McCarthy, G. Temporal cortex activation in humans viewing eye and mouth movements. J. Neurosci., 1998, 18: 2188–2199.

    Google Scholar 

  • Sams, M., Hietanen, R., Hari, R., Ilmoniemi, J. and Lounasmaa, V.O. Face-specific responses from the human inferior occipito-temporal cortex. Neuroscience, 1997, 77: 49–55.

    Google Scholar 

  • Sergent, J., Ohta, S. and MacDonald, B. Functional neuroanatomy of face and object processing a positron emission tomography study. Brain, 1992, 115: 15–36.

    Google Scholar 

  • Sergent, J. and Poncet, M. From covert to overt recognition of faces in a prosopagnosic patient. Brain, 1990, 113: 989–1004.

    Google Scholar 

  • Sugase, Y., Yamane, S., Ueno, S. and Kawano, K. Global and fine information coded by single neurons in the temporal visual cortex. Nature, 1999, 400: 869–873.

    Google Scholar 

  • Suzuki, S. and Cavanagh, P. Facial organization blocks access to low-level features: An object inferiority effect. J. Exp. Psychol., 1995, 21: 901–913.

    Google Scholar 

  • Swithenby, S.J., Bailey, A.J., Brtigam, S., Josephs, O.E., Jousmäki, C.D. and Tesche, C.D. Neural processing of human faces: a magnetoencephalographic study. Exp. Brain Res., 1998, 118: 501–510.

    Google Scholar 

  • Takahashi, N., Kawamura, M., Hirayama, K., Shiota., J. and Isono, O. Prosopagnosia: a clinical and anatomical study of four patients. Cortex, 1995, 31: 317–29.

    Google Scholar 

  • Tanaka, J.W. and Farah, M.J. Parts and wholes in face recognition. Q. J. Exp. Psychol. A, 1993, 46: 225–245.

    Google Scholar 

  • Watanabe, S., Kakigi, R., Koyama, S. and Kirino, E. Human face perception traced by magneto-and electroencephalography. Cog. Brain Res., 1999a, 8: 125–142.

    Google Scholar 

  • Watanabe, S., Kakigi, R., Koyama, S. and Kirino, E. It takes longer to recognize the eyes than the whole face in humans. Neuroreport, 1999b, 10: 2193–2198.

    Google Scholar 

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Authors and Affiliations

  1. Departments of Physiology, Faculty of Medicine,, Toyama Medical and Pharmaceutical University,, Toyama,, Japan

    Takashi Shibata, Hisao Nishijo, Ryoi Tamura, Keiichi Miyamoto, Satoshi Eifuku & Taketoshi Ono

  2. Neurosurgery, Faculty of Medicine,, Toyama Medical and Pharmaceutical University,, Toyama,, Japan

    Takashi Shibata, Shunro Endo & Taketoshi Ono

  3. CREST, JST,, Japan

    Hisao Nishijo, Ryoi Tamura & Satoshi Eifuku

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  1. Takashi Shibata
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  2. Hisao Nishijo
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  3. Ryoi Tamura
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  4. Keiichi Miyamoto
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  5. Satoshi Eifuku
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  6. Shunro Endo
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  7. Taketoshi Ono
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Shibata, T., Nishijo, H., Tamura, R. et al. Generators of Visual Evoked Potentials for Faces and Eyes in the Human Brain as Determined by Dipole Localization. Brain Topogr 15, 51–63 (2002). https://doi.org/10.1023/A:1019944607316

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