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Biochemical and Physiological Mechanisms of Female Genital Sexual Arousal

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Abstract

Limited studies are available concerning physiological and biochemical mechanisms involved in female sexual function and dysfunction. The paucity of physiological and biochemical data pertaining to genital sexual arousal function is attributed, in part, to lack of reliable experimental models and tools for the investigation of female sexual arousal. This review summarizes research efforts from a number of laboratories in which several experimental models have been established. These include the development of in vivo animal models, organ bath studies, and the establishment of cell cultures. The availability of such experimental model systems have facilitated efforts aimed at defining the neurotransmitters responsible for vaginal smooth muscle relaxation, the role of sex steroid hormones and their receptors in modulating genital hemodynamics, smooth muscle contractility, and neurotransmitter receptor expression. A comprehensive and integral understanding of female sexual function requires detailed investigation of the vascular, neurological (central and peripheral), and structural components of this complex physiological process.

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REFERENCES

  • Al-Hijji, J., & Batra, S. (1999). Down regulation by estrogen of nitric oxide synthase activity in the female rabbit lower urinary tract. Urology, 53, 637–641.

    Google Scholar 

  • Al-Hijji, J., Larsson, B., & Batra, S. (2000). Nitric oxide synthase in the rabbit uterus and vagina: Hormonal regulation and functional significance. Biology of Reproduction, 62, 1387–1392.

    Google Scholar 

  • Al-Hijji, J., Larsson, I., & Batra, S. (2001). Effect of ovarian steroids on nitric oxide synthase in the rat uterus, cervix and vagina. Life Sciences, 69, 1133–1142.

    Google Scholar 

  • Batra, S., & Al-Hijji, J. (1998). Characterization of nitric oxide synthase activity in rabbit uterus and vagina: Down regulation by estrogen. Life Sciences, 62, 2093–2100.

    Google Scholar 

  • Berman, J. R., McCarthy, M. M., & Kyprianou, N. (1998). Effect of estrogen withdrawal on nitric oxide synthase expression and apoptosis in the rat vagina. Urology, 51, 650–656.

    Google Scholar 

  • Caruso, S., Intelisano, G., Lupo, L., & Agnello, C. (2001). Premenopausal women affected by sexual arousal disorder treated with sildenafil: A double-blind, cross-over, placebo-controlled study. British Journal of Obstetrics and Gynecology, 108, 623–628.

    Google Scholar 

  • Cellek, S., & Moncada, S. (1998). Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit. British Journal of Pharmacology, 125, 1627–1629.

    Google Scholar 

  • Giraldi, A., Persson, K., Werkstrom, V., Alm, P., Wagner, G., & Andersson, K. E. (2001). Effects of diabetes on neurotransmission in rat vaginal smooth muscle. International Journal of Impotence Research, 13, 58–66.

    Google Scholar 

  • Giuliano, F., Allard, J., Compagnie, S., Alexandre, L., Droupy, S., & Bernabe, J. (2001). Vaginal physiological changes in a model of sexual arousal in anesthetized rats. American Journal of Physiology, 281, R140-R149.

    Google Scholar 

  • Hoyle, C. H., Stones, R. W., Robson, T., Whitley, K., & Burnstock, G. (1996). Innervations of vasculature and microvasculature of the human vagina byNOSand neuropeptide-containing nerves. Journal of Anatomy, 188, 633–644.

    Google Scholar 

  • Kaplan, S. A., Reis, R. B., Kohn, I. J., Ikeguchi, E. F., Laor, E., Te, A. E., et al. (1999). Safety and efficacy of sildenafil in postmenopausal women with sexual dysfunction. Urology, 53, 481–486.

    Google Scholar 

  • Laan, E., & Everaerd, W. (1998). Physiological measures of vaginal vasocongestion. International Journal of Impotence Research, 10(Suppl. 2), S107-S110.

    Google Scholar 

  • Levin, R. J. (1991). VIP, vagina, clitoral and periuretheral glans: An update on human female genital arousal. Experimental and Clinical Endocrinology, 98, 61–69.

    Google Scholar 

  • Levin, R. J. (1992). The mechanisms of human female sexual arousal. Annual Review of Sex Research, 3, 1–12.

    Google Scholar 

  • Levin, R. J. (1998). Sex and the human female reproductive tract-What really happens during and after coitus. International Journal of Impotence Research, 10(Suppl. 1), S14-S21.

    Google Scholar 

  • Levin, R. J., & Wagner, G. (1978). Haemodynamic changes of the human vagina during sexual arousal assessed by a heated oxygen electrode [Proceedings]. Journal of Physiology, 275, 23P-24P.

    Google Scholar 

  • Levin, R. J., & Wagner, G. (1985). Orgasm in women in the laboratory-Quantitative studies on duration, intensity, latency, and vaginal blood flow. Archives of Sexual Behavior, 14, 439–449.

    Google Scholar 

  • Li, Y., Kuang, K., Yerxa, B., Wen, Q., Rosskothen, H., & Fischbarg, J. (2001). Rabbit conjunctival epithelium transports fluid, and P2Y2 receptor agonists stimulate Cl¡ and fluid secretion. American Journal of Physiology, 281, C595-C602.

    Google Scholar 

  • Meston, C. M., Gorzalka, B. B., & Wright, J. M. (1997). Inhibition of subjective and physiological sexual arousal in women by clonidine. Psychosomatic Medicine, 59, 399–407.

    Google Scholar 

  • Meston, C. M., & Heiman, J. R. (1998). Ephedrine-activated physiological sexual arousal in women. Archives of General Psychiatry, 55, 652–656.

    Google Scholar 

  • Min, K., Kim, N. N., McAuley, I., Stankowicz, M., Goldstein, I., & Traish, A. M. (2000). Sildenafil augments pelvic nerve-mediated female genital sexual arousal in the anesthetized rabbit. International Journal of Impotence Research, 12(Suppl. 3), S32-S39.

    Google Scholar 

  • Min, K., Munarriz, R., Berman, J., Kim, N. N., Goldstein, I., Traish, A. M., et al. (2001b). Hemodynamic evaluation of the female sexual arousal response in an animal model. Journal of Sex and Marital Therapy, 27, 557–565.

    Google Scholar 

  • Min, K., O'Connell, L., Munarriz, R., Huang, Y. H., Choi, S., Kim, N., et al. (2001a). Experimental models for the investigation of female sexual function and dysfunction. International Journal of Impotence Research, 13, 151–156.

    Google Scholar 

  • Min, K., Munarriz, R., Kim, N, N., Choi, S., O'Connell, L., Goldstein, I., & Traish A. M. (2002a). Effects of ovariectomy and estrogen replacement on basal and pelvic nerve stimulated vaginal lubrication in an animal model. Journal of Sex and Marital Therapy, In Press.

  • Min, K., Munarriz, R., Kim, N, N., Goldstein, I., & Traish A. (2002b). Effects of ovariectomy and estrogen and androgen treatment on sildenafil-mediated changes in female genital blood flow and vaginal lubrication in the animal model. American Journal of Obstetrics and Gynecology, In Press.

  • Min, K., Munarriz, R., Yerxa, B. R., Goldstein, I., Shaver, S. R., Cowlen, M. S., Traish, A. M. (2002c). Selective P2Y2 receptor agonists stimulate vaginal moisture in ovariectomized rabbits. Fertility and Steriliry, In Press.

  • Morokoff, P. J., & Heiman, J. R. (1980). Effects of erotic stimuli on sexually functional and dysfunctional women: Multiple measures before and after sex therapy. Behaviour Research and Therapy, 18, 127–133.

    Google Scholar 

  • Ottesen, B. (1983). Vasoactive intestinal peptide as a neurotransmitter in the female genital tract. American Journal of Obstetrics and Gynecology, 147, 208–224.

    Google Scholar 

  • Ottesen, B., Pedersen, B., Nielsen, J., Dalgaard, D., Wagner, G., & Fahrenkrug, J. (1987). Vasoactive intestinal polypeptide (VIP) provokes vaginal lubrication in normal women. Peptides, 8, 797–800.

    Google Scholar 

  • Ottesen, B., Ulrichsen, H., Fahrenkrug, J., Larsen, J. J., Wagner, G., Schierup, L., et al. (1982). Vasoactive intestinal polypeptide and the female genital tract: Relationship to reproductive phase and delivery. American Journal of Obstetrics and Gynecology, 43, 414–420.

    Google Scholar 

  • Palace, E. M., & Gorzalka, B. B. (1990). The enhancing effects of anxiety on arousal in sexually dysfunctional and functionalwomen. Journal of Abnormal Psychology, 99, 403–411.

    Google Scholar 

  • Palle, C., Bredkjaer, H. E., Ottesen, B., & Fahrenkrug, J. (1990). Vasoactive intestinal polypeptide and human vaginal blood flow: Comparison between transvaginal and intravenous administration. Clinical and Experimental Pharmacology and Physiology, 17, 61–68.

    Google Scholar 

  • Park, K., Ahn, K., Lee, S., Ryu, S., Park, Y., & Azadzoi, K. M. (2001). Decreased circulating levels of estrogen alter vaginal and clitoral blood flow and structure in the rabbit. International Journal of Impotence Research, 13, 116–124.

    Google Scholar 

  • Park, K., Goldstein, I., Andry, C., Siroky, M., Krane, R. J., & Azadzoi, K. (1997). Vasculogenic female sexual dysfunction: The hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency. International Journal of Impotence Research, 9, 27–37.

    Google Scholar 

  • Park, K., Moreland, R. B., Goldstein, I., Atala, A., & Traish, A. (1998). Sildenafil inhibits phosphodiesterase type 5 in human clitoral corpus cavernosum smooth muscle. Biochemical and Biophysical Research Communications, 249, 612–617.

    Google Scholar 

  • Pintor, J., Peral, A., Hoyle, C. H., Redick, C., Douglass, J., Sims, I., et al. (2002). Effects of diadenosine polyphosphates on tear secretion in New Zealand white rabbits. Journal of Pharmacology and Experimental Therapeutics, 300, 291–297.

    Google Scholar 

  • Read, S., King, M., & Watson, J. (1997). Sexual dysfunction in primary medical care: Prevalence, characteristics and detection by the general practitioner. Journal of Public Health Medicine, 19, 387–391

    Google Scholar 

  • Riley, A. J., & Riley, E. J. (1981). The effect of labetalol and propranolol on the pressor response to sexual arousal in women. British Journal of Clinical Pharmacology, 12, 341–344.

    Google Scholar 

  • Rosen, R. C., Taylor, J. F., Leiblum, S. R., & Bachmann, G. A. (1993). Prevalence of sexual dysfunction in women: Results of a survey study of 329 women in an outpatient gynecological clinic. Journal of Sex and Marital Therapy, 19, 171–188.

    Google Scholar 

  • Tarcan, T., Siroky, M. B., Park, K., Goldstein, I., & Azadzoi, K. M. (2000). Systemic administration of apomorphine improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit. International Journal of Impotence Research, 12, 235–240.

    Google Scholar 

  • Traish, A. M., Moreland, R. B., Huang, Y.-H., Kim, N. N., Berman, J., & Goldstein, I. (1999). Development of human and rabbit vaginal smooth muscle cell cultures: Effects of vasoactive agents on intracellular levels of cyclic nucleotides. Molecular Cell Biology Research Communications, 2, 131–137.

    Google Scholar 

  • Traish, A. M., Kim, N., Min, K., Munarriz, R., & Goldstein, I. (2002a). Role of androgens in female genital sexual arousal: Receptor expression, structure, and function. Fertility and Sterility, 77 (Suppl. 4), 11–18.

    Google Scholar 

  • Traish, A. M., Kim, N., Min, K., Munarriz, R., & Goldstein, I. (2002b). Androgens in female genital sexual arousal function: a biochemical perspective. Journal of Sex and Marital Therapy, 28 (Suppl. 1), 233–244.

    Google Scholar 

  • Vachon, P., Simmerman, N., Zahran, A. R., & Carrier, S. (2000). Increases in clitoral and vaginal blood flow following clitoral and pelvic plexus nerve stimulations in the female rat. International Journal of Impotence Research, 12, 53–57.

    Google Scholar 

  • Vemulapalli, S., & Kurowski, S. (2000). Sildenafil relaxes rabbit clitoral corpus cavernosum. Life Sciences, 67, 23–29.

    Google Scholar 

  • Wagner, G. (1992). Aspects of genital physiology and pathology. Seminars in Neurology, 12, 87–97.

    Google Scholar 

  • Yoon, H. N., Chung, W. S., Park, Y. Y., Shim, B. S., Han, W. S., & Kwon, S.W. (2001). Effects of estrogen on nitric oxide synthase and histological composition in the rabbit clitoris and vagina. International Journal of Impotence Research, 13, 205–211.

    Google Scholar 

  • Ziessen, T., Moncada, S., & Cellek, S. (2002) Characterization of the non-nitrergic NANC relaxation responses in the rabbit vagina wall. British Journal of Pharmacology, 135, 546–554.

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts

    Abdulmaged M. Traish

  2. Department of Urology, Boston University School of Medicine, Boston, Massachusetts

    Abdulmaged M. Traish, Noel N. Kim, Ricardo Munarriz, Robert Moreland & Irwin Goldstein

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  1. Abdulmaged M. Traish
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  2. Noel N. Kim
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  3. Ricardo Munarriz
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  4. Robert Moreland
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Traish, A.M., Kim, N.N., Munarriz, R. et al. Biochemical and Physiological Mechanisms of Female Genital Sexual Arousal. Arch Sex Behav 31, 393–400 (2002). https://doi.org/10.1023/A:1019831906508

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