Abstract
This study quantifies variance components of two-dimensional strains in the left-ventricular heart wall assessed by magnetic resonance (MR) tagging in 18 healthy xxvolunteers. For a 7-mm tagging grid and homogeneous strain analysis, the intersubject variability and measurement error were estimated, as well as the intra- and interobserver variability. The variance components were calculated for the mean strain of a circumferential sector. The results show that the measurement error was almost equal to the intra-observer variability. With four circumferential sectors of 90° each, approximately 65% of the total variance in εr and εc was due to intersubject variability, the remaining 35% was due to measurement error. With 12 sectors of 30° each, the intersubject variability and measurement error both contributed 50% to the total variance. With 18 sectors of 20° each, only 40% of the total variance was due to intersubject variability. The total variability increased with the number of sectors and therefore the number of sectors used in a study will be a trade-off between segment size (defining spatial resolution) and variability.
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Axel L, Dougherty L. Heart wall motion: improved method of spatial modulation of magnetization for MR imaging. Radiology 1989; 172: 349-350.
Zerhouni EA, Parish DM, Rogers WJ, Yang A, Shapiro EP. Human heart: tagging with MR imaging — a method for noninvasive assessment of myocardial motion. Radiology 1988; 169: 59-63.
Young AA, Imai H, Chang CN, Axel L. Two-dimensional left ventricular deformation during systole using magnetic resonance imaging with spatial modulation of magnetization. Circulation 1994; 89: 740-752.
Doyle M, Scheidegger MB, de Graaf RG, Vermeulen J, Pohost GM. Coronary artery imaging in multiple 1-sec breath holds. Magn Reson Imaging 1993; 11: 3-6.
Henkelman RM. Measurement of signal intensities in the presence of noise in MR images. Med Phys 1985; 12: 232-233.
Stuber M, Fischer SE, Scheidegger MB, Boesiger P. Toward high-resolution myocardial tagging. Magn Reson Med 1999; 41: 639-643.
Axel L, Goncalves RC, Bloomgarden DC. Regional heart wall motion: two-dimensional analysis and functional imaging with MR imaging. Radiology 1992; 183: 745-750.
Young AA, Kraitchman DL, Dougherty L, Axel L. Tracking and finite element analysis of stripe deformation in magnetic resonance tagging. IEEE Trans Med Imaging 1995; 14: 413-421.
Kass M, Witkin A, Terzopoulos D. Snakes: active contour models. Int J Comp Vision 1988; 1: 321-331.
Fung YC. A first course in continuum mechanics: for physical and biological scientists and engineers. Englewood Cliffs, NJ: Prentice-Hall, 1994.
Goldstein H. Multilevel Statistical Models. London: Adward Arnold, 1995.
Bryk AS, Raudenbush SW. Hierarchical Linear Models. Newburey Park, CA: Sage, 1992.
Marcus JT, Smeenk HG, Kuijer JPA, van der Geest RJ, Heethaar RM, van Rossum AC. Flow profiles in the left anterior descending and the right coronary artery assessed by MR velocity quantification: effects of through-plane and in-plane motion of the heart. J Comput Assist Tomogr 1999; 23: 567-576.
MacGowan GA, Shapiro EP, Azhari H, et al. Noninvasive measurement of shortening in the fiber and cross-fiber directions in the normal human left ventricle and in idiopathic dilated cardiomyopathy. Circulation 1997; 96: 535-541.
Young AA, Kramer CM, Ferrari VA, Axel L, Reichek N. Three-dimensional left ventricular deformation in hypertrophic cardiomyopathy. Circulation 1994; 90: 854-867.
Waldman LK, Fung YC, Covell JW. Transmural myocardial deformation in the canine left ventricle. Normal in vivo three-dimensional finite strains. Circ Res 1985; 57: 152-163.
McVeigh ER. MRI of myocardial function: motion tracking techniques. Magn Reson Imaging 1996; 14: 137-150.
Goldstein H, Rashash J, Plewis I, et al. A user's guide to MlwiN. Multilevel Models Project, Institute of Education, University of London, 1998.
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Kuijer, J.P., Marcus, J.T., Götte, M.J. et al. Variance components of two-dimensional strain parameters in the left-ventricular heart wall obtained by magnetic resonance tagging. Int J Cardiovasc Imaging 17, 49–60 (2001). https://doi.org/10.1023/A:1010629614081
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DOI: https://doi.org/10.1023/A:1010629614081