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Historical and Epidemiologic Background of Human Premalignant Breast Disease

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Abstract

Premalignant breast disease in humans is a concept that admits to a broad range of elements and possible determinants predicting the likelihood of developing breast cancer. Most of these elements are relative, such as the risk of breast cancer for women that is 130 times that of men and peaks at a younger age by about 10 years. Breast cancer is clearly a stochastic, multifactorial process that evolves over many years in which we must make predictions by likelihood. This review will present the most specially defined and reliably proven of these elements, highlighting anatomic and molecular factors.

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Authors and Affiliations

  1. Department of Pathology, MCN C3321, Vanderbilt University Medical Center, Nashville, Tennessee, 37232

    David L. Page

  2. Department of Pathology, MCN C3321, Vanderbilt University Medical Center, Nashville, Tennessee, 37232

    Roy A. Jensen & Jean F. Simpson

  3. Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee, 37232

    Roy A. Jensen

  4. Department of Preventive Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, 37232

    William D. Dupont

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  1. David L. Page
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  2. Roy A. Jensen
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  3. Jean F. Simpson
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  4. William D. Dupont
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Page, D.L., Jensen, R.A., Simpson, J.F. et al. Historical and Epidemiologic Background of Human Premalignant Breast Disease. J Mammary Gland Biol Neoplasia 5, 341–349 (2000). https://doi.org/10.1023/A:1009521726605

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